VALIDATION OF THE CT CLOCK TOOL FOR ESTIMATING ONSET TIME OF ISCHAEMIC STROKE: ESNR 2024

Research output: Contribution to journalMeeting abstractpeer-review

Abstract / Description of output

Introduction: When time of ischaemic stroke onset is
unknown, CT perfusion or MRI can confirm eligibility
for thrombolysis and thrombectomy treatment. However,
‘advanced’ imaging is not always available. We have developed
a novel method for estimating the onset time of ischaemic
stroke using non-enhanced CT brain imaging alone,
the CT Clock Tool. We aim to validate our method using
routinely-collected data, and to test inter-rater reliability and
user satisfaction among front-line clinicians.

Methods: Validation will use CT brain imaging and
linked stroke audit data from 100 sequential patients
within the Scottish National Safehaven. We will compare
stoke onset time estimates with actual elapsed time and
derive the diagnostic accuracy of our method for determining
treatment eligibility (e.g. <4.5 hours for thrombolysis).
Inter-rater reliability and satisfaction testing will
use data from an ongoing prospective feasibility study
of the CT Clock Tool (registration: NCT06028802). We
will compare stroke onset time estimates for up to six
clinicians per patient, using Krippendorff’s Alpha to
test agreement. We will assess the user-friendliness of
our method (ease of use, time taken) on five-point Likert
scales. We will present results with 95% confidence
intervals.

Results: Study is ongoing. We will present the precision
of stroke onset time estimates, the sensitivity/ specificity
of treatment eligibility estimates, and agreement/ satisfaction
among front-line clinicians.

Discussion & Conclusion: Our study aims to validate the
CT Clock Tool, a method for estimating the time of ischaemic
stroke onset.
Original languageEnglish
Article number1-P89
Pages (from-to)118
Number of pages1
JournalNeuroradiology
Volume66
Issue number1
DOIs
Publication statusPublished - 6 Sept 2024

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