Variance in brain volume with advancing age: implications for defining the limits of normality

David Dickie, Dominic E Job, David Rodriguez Gonzalez, Susan D Shenkin, Trevor S Ahearn, Alison D Murray, Joanna M Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract

Statistical models of normal ageing brain tissue volumes may support earlier diagnosis of increasingly common, yet still fatal, neurodegenerative diseases. For example, the statistically defined distribution of normal ageing brain tissue volumes may be used as a reference to assess patient volumes. To date, such models were often derived from mean values which were assumed to represent the distributions and boundaries, i.e. percentile ranks, of brain tissue volume. Since it was previously unknown, the objective of the present study was to determine if this assumption was robust, i.e. whether regression models derived from mean values accurately represented the distributions and boundaries of brain tissue volume at older ages.
Original languageEnglish
Article numbere84093
JournalPLoS ONE
Volume8
Issue number12
DOIs
Publication statusPublished - 19 Dec 2013

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