Variant Creutzfeldt-Jakob disease

H J T Ward, M W Head, R G Will, J W Ironside

Research output: Contribution to journalArticlepeer-review

Abstract

Variant CJD is a novel human prion disease that represents the first known occasion in which animal prion diseases have been transmitted to humans. There are many uncertainties concerning vCJD, including the mechanism of transmission between species, the extent of human exposure to the BSE agent, the infectious dose for humans, and the future burden of human disease. It is hoped that continuing scientific research may lead to answers to some of these questions and that further understanding of the mechanism of prion replication may lead to the development of effective treatment. Indeed a recent publication has suggested that the drugs quinacrine or chloropromazine may be candidates for the treatment of human prion diseases [42].

Original languageEnglish
Pages (from-to)87-108
Number of pages22
JournalClinics in laboratory medicine
Volume23
Issue number1
Publication statusPublished - Mar 2003

Keywords

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Cerebral Cortex
  • Child
  • Creutzfeldt-Jakob Syndrome
  • Great Britain
  • Humans
  • Middle Aged
  • Survival Rate

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