Variant Creutzfeldt-Jakob disease: a cause for concern. Review of the evidence for risk of transmission through abdominal lymphoreticular tissue surgery

S B Olsen, A Sheikh, D Peck, Ali Darzi

Research output: Contribution to journalReview articlepeer-review

Abstract

BACKGROUND: Concern has long existed regarding the possible iatrogenic spread of variant Creutzfeldt-Jakob disease (v-CJD) through surgery. This had been fueled by recent reports of bovine spongiform encephalopathy in U.S. cattle and the first probable case of blood transmission of v-CJD in the UK.

METHODS: Systematic review of experimental and nonexperimental studies. Studies identified from searches of Medline, Embase, Cochrane Library, Science Citation Index medical databases, searching bibliographies of retrieved papers, and personal communication with international experts in the field.

RESULTS: Six articles satisfied our search criteria. Evidence stems from case reports, case series, and cross-sectional studies. There are no published cases of surgically transmitted v-CJD.

CONCLUSION: We found evidence of v-CJD prion agents in the spleen, appendix, rectum, and adrenal glands of affected patients and evidence of v-CJD prion in the appendix of patients in the preclinical stage of the disease. The risk of transmission of v-CJD prion during abdominal surgery is currently unquantifiable.

Original languageEnglish
Pages (from-to)747-50
Number of pages4
JournalSurgical Endoscopy
Volume19
Issue number6
DOIs
Publication statusPublished - Jun 2005

Keywords

  • Abdomen
  • Creutzfeldt-Jakob Syndrome
  • Endoscopy
  • Equipment Contamination
  • Humans
  • Lymphoid Tissue
  • Mononuclear Phagocyte System
  • Risk Factors
  • Surgical Procedures, Operative
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Fingerprint Dive into the research topics of 'Variant Creutzfeldt-Jakob disease: a cause for concern. Review of the evidence for risk of transmission through abdominal lymphoreticular tissue surgery'. Together they form a unique fingerprint.

Cite this