Variation in the matrix metalloproteinase-1 gene and risk of coronary heart disease

Shu Ye, Catharine R. Gale, Christopher N Martyn

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Matrix metalloproteinase-1 (MMP-1), a proteolytic enzyme able to degrade types I and III collagens, is present in atherosclerotic lesions but absent from the normal blood vessel wall. The recent observation that, in a transgenic mouse model, MMP-1 gene expression slows the development and progression of atherosclerotic plaques suggests that it may play a role in human atherogenesis. We investigated whether coronary heart disease was associated with a functional polymorphism in the human MMP-1 gene. In addition, we examined a polymorphism in the human MMP-3 gene that was previously reported to be associated with progression of coronary atherosclerosis.
Original languageEnglish
Pages (from-to)1668-71
Number of pages4
JournalEuropean Heart Journal
Volume24
Issue number18
Publication statusPublished - 2003

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