Variation of BMP3 Contributes to Dog Breed Skull Diversity

Jeffrey J. Schoenebeck; Sarah A. Hutchinson; Alexandra Byers; Holly C. Beale; Blake Carrington; Daniel L. Faden; Maud Rimbault; Brennan Decker; Jeffrey M. Kidd; Raman Sood; Adam R. Boyko; John W. Fondon; Robert K. Wayne; Carlos D. Bustamante; Brian Ciruna; Elaine A. Ostrander

doi:10.1371/journal.pgen.1002849

Variation of BMP3 Contributes to Dog Breed Skull Diversity

Jeffrey J. Schoenebeck^*, Sarah A. Hutchinson, Alexandra Byers, Holly C. Beale, Blake Carrington, Daniel L. Faden, Maud Rimbault, Brennan Decker, Jeffrey M. Kidd, Raman Sood, Adam R. Boyko, John W. Fondon, Robert K. Wayne, Carlos D. Bustamante, Brian Ciruna, Elaine A. Ostrander

^*Corresponding author for this work

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.

Original language	English
Article number	1002849
Number of pages	11
Journal	PLoS Genetics
Volume	8
Issue number	8
DOIs	https://doi.org/10.1371/journal.pgen.1002849
Publication status	Published - Aug 2012

Keywords / Materials (for Non-textual outputs)

PROTEIN-KINASE-II
CHROMOSOME ASSIGNMENT
GENETIC-ANALYSIS
SELECTIVE SWEEP
ZEBRAFISH
DIFFERENTIATION
ASSOCIATION
EXPRESSION
SEQUENCE
DENSITY

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10.1371/journal.pgen.1002849

Variation of BMP3 Contributes to Dog Breed Skull Diversity
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Schoenebeck, J. J., Hutchinson, S. A., Byers, A., Beale, H. C., Carrington, B., Faden, D. L., Rimbault, M., Decker, B., Kidd, J. M., Sood, R., Boyko, A. R., Fondon, J. W., Wayne, R. K., Bustamante, C. D., Ciruna, B., & Ostrander, E. A. (2012). Variation of BMP3 Contributes to Dog Breed Skull Diversity. PLoS Genetics, 8(8), Article 1002849. https://doi.org/10.1371/journal.pgen.1002849

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title = "Variation of BMP3 Contributes to Dog Breed Skull Diversity",

abstract = "Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.",

keywords = "PROTEIN-KINASE-II, CHROMOSOME ASSIGNMENT, GENETIC-ANALYSIS, SELECTIVE SWEEP, ZEBRAFISH, DIFFERENTIATION, ASSOCIATION, EXPRESSION, SEQUENCE, DENSITY",

author = "Schoenebeck, {Jeffrey J.} and Hutchinson, {Sarah A.} and Alexandra Byers and Beale, {Holly C.} and Blake Carrington and Faden, {Daniel L.} and Maud Rimbault and Brennan Decker and Kidd, {Jeffrey M.} and Raman Sood and Boyko, {Adam R.} and Fondon, {John W.} and Wayne, {Robert K.} and Bustamante, {Carlos D.} and Brian Ciruna and Ostrander, {Elaine A.}",

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AU - Carrington, Blake

AU - Faden, Daniel L.

AU - Rimbault, Maud

AU - Decker, Brennan

AU - Kidd, Jeffrey M.

AU - Sood, Raman

AU - Boyko, Adam R.

AU - Fondon, John W.

AU - Wayne, Robert K.

AU - Bustamante, Carlos D.

AU - Ciruna, Brian

AU - Ostrander, Elaine A.

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AB - Since the beginnings of domestication, the craniofacial architecture of the domestic dog has morphed and radiated to human whims. By beginning to define the genetic underpinnings of breed skull shapes, we can elucidate mechanisms of morphological diversification while presenting a framework for understanding human cephalic disorders. Using intrabreed association mapping with museum specimen measurements, we show that skull shape is regulated by at least five quantitative trait loci (QTLs). Our detailed analysis using whole-genome sequencing uncovers a missense mutation in BMP3. Validation studies in zebrafish show that Bmp3 function in cranial development is ancient. Our study reveals the causal variant for a canine QTL contributing to a major morphologic trait.

KW - PROTEIN-KINASE-II

KW - CHROMOSOME ASSIGNMENT

KW - GENETIC-ANALYSIS

KW - SELECTIVE SWEEP

KW - ZEBRAFISH

KW - DIFFERENTIATION

KW - ASSOCIATION

KW - EXPRESSION

KW - SEQUENCE

KW - DENSITY

U2 - 10.1371/journal.pgen.1002849

DO - 10.1371/journal.pgen.1002849

M3 - Article

SN - 1553-7404

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M1 - 1002849

ER -

Variation of BMP3 Contributes to Dog Breed Skull Diversity

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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