Varicella zoster virus DNA does not accumulate in infected human neurons

Nicholas L Baird, Jacqueline L Bowlin, Xiaoli Yu, Stipan Jonjić, Jürgen Haas, Randall J Cohrs, Don Gilden

Research output: Contribution to journalArticlepeer-review

Abstract

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.

Original languageEnglish
Pages (from-to)1-3
Number of pages3
JournalVirology
Volume458-459
DOIs
Publication statusPublished - Jun 2014
Externally publishedYes

Keywords

  • Cell Line
  • DNA, Viral
  • Herpesvirus 3, Human
  • Humans
  • Neurons
  • Viral Plaque Assay

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