Varicella zoster virus DNA does not accumulate in infected human neurons

Nicholas L Baird; Jacqueline L Bowlin; Xiaoli Yu; Stipan Jonjić; Jürgen Haas; Randall J Cohrs; Don Gilden

doi:10.1016/j.virol.2014.04.014

Varicella zoster virus DNA does not accumulate in infected human neurons

Nicholas L Baird, Jacqueline L Bowlin, Xiaoli Yu, Stipan Jonjić, Jürgen Haas, Randall J Cohrs, Don Gilden

Research output: Contribution to journal › Article › peer-review

Abstract

Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.

Original language	English
Pages (from-to)	1-3
Number of pages	3
Journal	Virology
Volume	458-459
DOIs	https://doi.org/10.1016/j.virol.2014.04.014
Publication status	Published - Jun 2014
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Cell Line
DNA, Viral
Herpesvirus 3, Human
Humans
Neurons
Viral Plaque Assay

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10.1016/j.virol.2014.04.014

Cite this

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title = "Varicella zoster virus DNA does not accumulate in infected human neurons",

abstract = "Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.",

keywords = "Cell Line, DNA, Viral, Herpesvirus 3, Human, Humans, Neurons, Viral Plaque Assay",

author = "Baird, {Nicholas L} and Bowlin, {Jacqueline L} and Xiaoli Yu and Stipan Jonji{\'c} and J{\"u}rgen Haas and Cohrs, {Randall J} and Don Gilden",

year = "2014",

month = jun,

doi = "10.1016/j.virol.2014.04.014",

language = "English",

volume = "458-459",

pages = "1--3",

journal = "Virology",

issn = "0042-6822",

publisher = "Academic Press",

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TY - JOUR

T1 - Varicella zoster virus DNA does not accumulate in infected human neurons

AU - Baird, Nicholas L

AU - Bowlin, Jacqueline L

AU - Yu, Xiaoli

AU - Jonjić, Stipan

AU - Haas, Jürgen

AU - Cohrs, Randall J

AU - Gilden, Don

PY - 2014/6

Y1 - 2014/6

N2 - Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.

AB - Varicella zoster virus (VZV) is an exclusively human neurotropic alphaherpesvirus. It is unclear why human neurons infected in vitro with VZV at low multiplicity of infection do not exhibit a cytopathic effect (CPE) even though all VZV genes are transcribed, VZV proteins from all kinetic classes are translated and minimal infectious virus is produced. Here, we show that the lack of VZV-induced CPE correlates with the low abundance of viral DNA.

KW - Cell Line

KW - DNA, Viral

KW - Herpesvirus 3, Human

KW - Humans

KW - Neurons

KW - Viral Plaque Assay

U2 - 10.1016/j.virol.2014.04.014

DO - 10.1016/j.virol.2014.04.014

M3 - Article

C2 - 24928033

SN - 0042-6822

VL - 458-459

SP - 1

EP - 3

JO - Virology

JF - Virology

ER -

Varicella zoster virus DNA does not accumulate in infected human neurons

Abstract

Keywords / Materials (for Non-textual outputs)

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