Vascular and plaque imaging with ultrasmall superparamagnetic particles of iron oxide

Shirjel R Alam, Colin Stirrat, Jennifer Richards, Saeed Mirsadraee, Scott I K Semple, George Tse, Peter Henriksen, David E Newby

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Cardiovascular Magnetic Resonance (CMR) has become a primary tool for non-invasive assessment of cardiovascular anatomy, pathology and function. Existing contrast agents have been utilised for the identification of infarction, fibrosis, perfusion deficits and for angiography. Novel ultrasmall superparamagnetic particles of iron oxide (USPIO) contrast agents that are taken up by inflammatory cells can detect cellular inflammation non-invasively using CMR, potentially aiding the diagnosis of inflammatory medical conditions, guiding their treatment and giving insight into their pathophysiology. In this review we describe the utilization of USPIO as a novel contrast agent in vascular disease.

Original languageEnglish
Pages (from-to)83
JournalJournal of Cardiovascular Magnetic Resonance
Volume17
Issue number1
DOIs
Publication statusPublished - 18 Sep 2015

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