Vascular Dysfunction in Chronic Obstructive Pulmonary Disease

John D. Maclay, David A. McAllister, Nicholas L. Mills, Finny P. Paterson, Christopher A. Ludlam, Ellen M. Drost, David E. Newby, William MacNee

Research output: Contribution to journalArticlepeer-review

Abstract

Rationale
Cardiovascular disease is a major cause of morbidity and mortality in patients with chronic obstructive pulmonary disease (COPD), which may in part be attributable to abnormalities of systemic vascular function. It is unclear whether such associations relate to the presence of COPD or prior smoking habit.

Objectives
To undertake a comprehensive assessment of vascular function in patients with COPD and healthy control subjects matched for smoking history.

Methods
Eighteen men with COPD were compared with 17 healthy male control subjects matched for age and lifetime cigarette smoke exposure. Participants were free from clinically evident cardiovascular disease.

Measurements and Main Results
Pulse wave velocity and pulse wave analysis were measured via applanation tonometry at carotid, radial, and femoral arteries. Blood flow was measured in both forearms using venous occlusion plethysmography during intrabrachial infusion of endothelium-dependent vasodilators (bradykinin, 100-1,000 pmol/min; acetylcholine, 5-20 mu g/min) and endothelium-independent vasodilators (sodium nitroprusside, 2-8 mu g/min; verapamil, 10-100 mu g/min). Tissue plasminogen activator (t-PA) was measured in venous plasma before and during bradykinin infusions. Patients with COPD have greater arterial stiffness (pulse wave velocity, 11 +/- 2 vs. 9 +/- 2 m/s; P = 0.003; augmentation index, 27 +/- 10 vs. 21 +/- 6%; P = 0.028), but there were no differences in endothelium-dependent and -independent vasomotor function or bradykinin-induced endothelial t-PA release (P > 0.05 for all).

Conclusions
COPD is associated with increased arterial stiffness independent of cigarette smoke exposure. However, this abnormality is not explained by systemic endothelial dysfunction. Increased arterial stiffness may represent the mechanistic link between COPD and the increased risk for cardiovascular disease associated with this condition.

Original languageEnglish
Pages (from-to)513-520
Number of pages8
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume180
Issue number6
DOIs
Publication statusPublished - 15 Sep 2009

Keywords

  • pulmonary disease
  • chronic obstructive
  • cardiovascular diseases
  • arterial stiffness
  • endothelial function

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