Vasopressin casts light on the suprachiasmatic nucleus

Takahiro Tsuji, Andrew J. Allchorne, Meng Zhang, Chiharu Tsuji, Vicky A Tobin, Rafael Pineda, Androniki Raftogianni, Javier E. Stern, Valery Grinevich, Gareth Leng, Mike Ludwig

Research output: Contribution to journalArticlepeer-review


In all animals, the transition between night and day engages a host of physiological and behavioural rhythms. These rhythms depend not on the rods and cones of the retina, but on retinal ganglion cells (RGCs) that detect the ambient light level in the environment. These project to the suprachiasmatic nucleus (SCN) of the hypothalamus to entrain circadian rhythms that are generated within the SCN. The neuropeptide vasopressin has an important role in this entrainment. Many SCN neurons express vasopressin, and it has been assumed that the role of vasopressin in the SCN reflects the activity of these cells. Here we show that vasopressin is also expressed in many retinal cells that project to the SCN. Light‐evoked vasopressin release contributes to the responses of SCN neurons to light, and enhances expression of the immediate early gene c‐fos in the SCN, which is involved in photic entrainment of circadian rhythms.
Original languageEnglish
Pages (from-to)3497-3514
JournalJournal of Physiology
Issue number11
Early online date14 May 2017
Publication statusE-pub ahead of print - 14 May 2017


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