Abstract
The effect of electrically evoked dendritic vasopressin release on noradrenaline release into the hypothalamic supraoptic nucleus was assessed by in vivo microdialysis in conjunction with high pressure liquid chromatography and electrochemical detection. Electrical activation of magnocellular supraoptic neurones by stimulation of their axons at the level of the neural lobe significantly increased noradrenaline release into the nucleus (2.5-fold, P<0.03). This increase was completely blocked by administration of a nonpeptide vasopressin V1a receptor antagonist via the microdialysis probe. These data suggest that dendritically released vasopressin facilitates noradrenaline release into the hypothalamic nucleus.
Original language | English |
---|---|
Pages (from-to) | 477-9 |
Number of pages | 3 |
Journal | Journal of Neuroendocrinology |
Volume | 12 |
Issue number | 6 |
Publication status | Published - Jun 2000 |
Keywords / Materials (for Non-textual outputs)
- Antidiuretic Hormone Receptor Antagonists
- Chromatography, High Pressure Liquid
- Electrochemistry
- Neurons
- Norepinephrine
- Piperidines
- Potassium
- Quinolones
- Supraoptic Nucleus
- Vasopressins