Vasopressin regulation of noradrenaline release within the supraoptic nucleus

M Ludwig, T Onaka, K Yagi

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of electrically evoked dendritic vasopressin release on noradrenaline release into the hypothalamic supraoptic nucleus was assessed by in vivo microdialysis in conjunction with high pressure liquid chromatography and electrochemical detection. Electrical activation of magnocellular supraoptic neurones by stimulation of their axons at the level of the neural lobe significantly increased noradrenaline release into the nucleus (2.5-fold, P<0.03). This increase was completely blocked by administration of a nonpeptide vasopressin V1a receptor antagonist via the microdialysis probe. These data suggest that dendritically released vasopressin facilitates noradrenaline release into the hypothalamic nucleus.

Original languageEnglish
Pages (from-to)477-9
Number of pages3
JournalJournal of Neuroendocrinology
Volume12
Issue number6
Publication statusPublished - Jun 2000

Keywords

  • Antidiuretic Hormone Receptor Antagonists
  • Chromatography, High Pressure Liquid
  • Electrochemistry
  • Neurons
  • Norepinephrine
  • Piperidines
  • Potassium
  • Quinolones
  • Supraoptic Nucleus
  • Vasopressins

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