Vexed by Red-Headed Conundrums

Jonathan L. Rees

Research output: Contribution to journalEditorialpeer-review


Reduced function alleles of the melanocortin 1 receptor (MC1R) lead to red hair, freckling, and sun sensitivity. They are also associated with an increased risk of skin cancer. But what pathways link gene variants with the cancer phenotype? In this issue, Robinson et al. describe their use of mouse transgenics to demonstrate that the MC1R signaling pathway influences cancer risk via mechanisms in addition to pigmentation.

Original languageEnglish
Pages (from-to)1771-1773
Number of pages3
JournalJournal of Investigative Dermatology
Issue number7
Publication statusPublished - Jul 2010

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