Virome of US bovine calf serum

Mohammadreza Sadeghi, Beatrix Kapusinszky, Danielle M. Yugo, Tung Gia Phan, Xutao Deng, Isis Kanevsky, Tanja Opriessnig, Amelia R. Woolums, David J. Hurley, Xiang-jin Meng, Eric Delwart

Research output: Contribution to journalArticlepeer-review


Using viral metagenomics we analyzed four bovine serum pools assembled from 715 calves in the United States. Two parvoviruses, bovine parvovirus 2 (BPV2) and a previously uncharacterized parvovirus designated as bosavirus (BosaV), were detected in 3 and 4 pools respectively and their complete coding sequences generated. Based on NS1 protein identity, bosavirus qualifies as a member of a new species in the copiparvovirus genus. Also detected were low number of reads matching ungulate tetraparvovirus 2, bovine hepacivirus, and several papillomaviruses. This study further characterizes the diversity of viruses in calf serum with the potential to infect fetuses and through fetal bovine serum contaminate cell cultures.
Original languageEnglish
Early online date15 Jan 2017
Publication statusE-pub ahead of print - 15 Jan 2017


  • Metagenomics
  • Parvovirus
  • Bosavirus
  • Cell culture

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