Virtual cardiac monolayers for electrical wave propagation

Nina Kudryashova, Valeriya Tsvelaya, Konstantin Agladze, Alexander Panfilov

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The complex structure of cardiac tissue is considered to be one of the main determinants of an arrhythmogenic substrate. This study is aimed at developing the first mathematical model to describe the formation of cardiac tissue, using a joint in silico-in vitro approach. First, we performed experiments under various conditions to carefully characterise the morphology of cardiac tissue in a culture of neonatal rat ventricular cells. We considered two cell types, namely, cardiomyocytes and fibroblasts. Next, we proposed a mathematical model, based on the Glazier-Graner-Hogeweg model, which is widely used in tissue growth studies. The resultant tissue morphology was coupled to the detailed electrophysiological Korhonen-Majumder model for neonatal rat ventricular cardiomyocytes, in order to study wave propagation. The simulated waves had the same anisotropy ratio and wavefront complexity as those in the experiment. Thus, we conclude that our approach allows us to reproduce the morphological and physiological properties of cardiac tissue.

Original languageEnglish
Pages (from-to)7887
Number of pages19
JournalScientific Reports
Issue number1
Publication statusPublished - 11 Aug 2017
Externally publishedYes

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Animals, Newborn
  • Cells, Cultured
  • Electrophysiological Phenomena
  • Fibroblasts/cytology
  • Immunohistochemistry
  • Microscopy, Fluorescence
  • Models, Theoretical
  • Myocytes, Cardiac/cytology
  • Rats


Dive into the research topics of 'Virtual cardiac monolayers for electrical wave propagation'. Together they form a unique fingerprint.

Cite this