Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo

Gareth J Hughes; Samantha Willey; Alexandra Cochrane; Clifford Leen; Jeanne E Bell; Peter Simmonds

doi:10.1097/QAD.0b013e3281e209e6

Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo

Gareth J Hughes, Samantha Willey, Alexandra Cochrane, Clifford Leen, Jeanne E Bell, Peter Simmonds

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

To demonstrate that HIV-1 immunocapture with an antibody against CD8 specifically captures virions derived from infected CD8 T cells, and to determine the proportion of HIV-1 derived from CD8 lymphocytes in plasma samples from HIV-infected individuals.

Original language	English
Pages (from-to)	1507-13
Number of pages	7
Journal	AIDS
Volume	21
Issue number	12
DOIs	https://doi.org/10.1097/QAD.0b013e3281e209e6
Publication status	Published - 31 Jul 2007

Keywords / Materials (for Non-textual outputs)

CD4 Lymphocyte Count
CD8-Positive T-Lymphocytes
Cells, Cultured
Disease Progression
HIV Infections
HIV-1
Humans
Proviruses
Reverse Transcriptase Polymerase Chain Reaction
T-Lymphocyte Subsets
Viral Load
Virion

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10.1097/QAD.0b013e3281e209e6

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title = "Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo",

abstract = "To demonstrate that HIV-1 immunocapture with an antibody against CD8 specifically captures virions derived from infected CD8 T cells, and to determine the proportion of HIV-1 derived from CD8 lymphocytes in plasma samples from HIV-infected individuals.",

keywords = "CD4 Lymphocyte Count, CD8-Positive T-Lymphocytes, Cells, Cultured, Disease Progression, HIV Infections, HIV-1, Humans, Proviruses, Reverse Transcriptase Polymerase Chain Reaction, T-Lymphocyte Subsets, Viral Load, Virion",

author = "Hughes, {Gareth J} and Samantha Willey and Alexandra Cochrane and Clifford Leen and Bell, {Jeanne E} and Peter Simmonds",

year = "2007",

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doi = "10.1097/QAD.0b013e3281e209e6",

language = "English",

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pages = "1507--13",

journal = "AIDS",

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publisher = "Lippincott Williams & Wilkins",

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T1 - Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo

AU - Hughes, Gareth J

AU - Willey, Samantha

AU - Cochrane, Alexandra

AU - Leen, Clifford

AU - Bell, Jeanne E

AU - Simmonds, Peter

PY - 2007/7/31

Y1 - 2007/7/31

N2 - To demonstrate that HIV-1 immunocapture with an antibody against CD8 specifically captures virions derived from infected CD8 T cells, and to determine the proportion of HIV-1 derived from CD8 lymphocytes in plasma samples from HIV-infected individuals.

AB - To demonstrate that HIV-1 immunocapture with an antibody against CD8 specifically captures virions derived from infected CD8 T cells, and to determine the proportion of HIV-1 derived from CD8 lymphocytes in plasma samples from HIV-infected individuals.

KW - CD4 Lymphocyte Count

KW - CD8-Positive T-Lymphocytes

KW - Cells, Cultured

KW - Disease Progression

KW - HIV Infections

KW - HIV-1

KW - Humans

KW - Proviruses

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - T-Lymphocyte Subsets

KW - Viral Load

KW - Virion

U2 - 10.1097/QAD.0b013e3281e209e6

DO - 10.1097/QAD.0b013e3281e209e6

M3 - Article

C2 - 17630544

SN - 0269-9370

VL - 21

SP - 1507

EP - 1513

JO - AIDS

JF - AIDS

IS - 12

ER -

Virus immunocapture provides evidence of CD8 lymphocyte-derived HIV-1 in vivo

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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