Visceral and subcutaneous fat have different origins and evidence supports a mesothelial source

You-Ying Chau, Roberto Bandiera, Alan Serrels, Ofelia M Martínez-Estrada, Wei Qing, Martin Lee, Joan Slight, Anna Thornburn, Rachel Berry, Sophie McHaffie, Roland H. Stimson, Brian R. Walker, Ramon Muñoz Chapuli, Andreas Schedl, Nick Hastie

Research output: Contribution to journalArticlepeer-review

Abstract

Fuelled by the obesity epidemic, there is considerable interest in the developmental origins of white adipose tissue (WAT) and the stem and progenitor cells from which it arises. Whereas increased visceral fat mass is associated with metabolic dysfunction, increased subcutaneous WAT is protective. There are six visceral fat depots: perirenal, gonadal, epicardial, retroperitoneal, omental and mesenteric, and it is a subject of much debate whether these have a common developmental origin and whether this differs from that for subcutaneous WAT. Here we show that all six visceral WAT depots receive a significant contribution from cells expressing Wt1 late in gestation. Conversely, no subcutaneous WAT or brown adipose tissue arises from Wt1-expressing cells. Postnatally, a subset of visceral WAT continues to arise from Wt1-expressing cells, consistent with the finding that Wt1 marks a proportion of cell populations enriched in WAT progenitors. We show that all visceral fat depots have a mesothelial layer like the visceral organs with which they are associated, and provide several lines of evidence that Wt1-expressing mesothelium can produce adipocytes. These results reveal a major ontogenetic difference between visceral and subcutaneous WAT, and pinpoint the lateral plate mesoderm as a major source of visceral WAT. They also support the notion that visceral WAT progenitors are heterogeneous, and suggest that mesothelium is a source of adipocytes.

Original languageEnglish
Pages (from-to)367-375
Number of pages9
JournalNature Cell Biology
Volume16
Issue number4
Early online date9 Mar 2014
DOIs
Publication statusPublished - Apr 2014

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