Visualizing Kinetically Robust (Co4L6)-L-III Assemblies in Vivo: SPECT Imaging of the Encapsulated [Tc-99m]TcO4- Anion

Benjamin P. Burke; William Grantham; Michael J. Burke; Gary. S. Nichol; David Roberts; Isaline Renard; Rebecca Hargreaves; Christopher Cawthorne; Stephen J. Archibald; Paul J. Lusby

doi:10.1021/jacs.8b09582

Visualizing Kinetically Robust (Co4L6)-L-III Assemblies in Vivo: SPECT Imaging of the Encapsulated [Tc-99m]TcO4- Anion

Benjamin P. Burke, William Grantham, Michael J. Burke, Gary. S. Nichol, David Roberts, Isaline Renard, Rebecca Hargreaves, Christopher Cawthorne, Stephen J. Archibald, Paul J. Lusby

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Non-covalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the gamma emitting [99mTc]TcO4− anion, under conditions compatible with in vivo administration. Subsequent SPECT imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

Original language	English
Pages (from-to)	16877–16881
Number of pages	5
Journal	Journal of the American Chemical Society
Volume	140
Issue number	49
Early online date	28 Nov 2018
DOIs	https://doi.org/10.1021/jacs.8b09582
Publication status	Published - 12 Dec 2018

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20181207 Lusby visualizing robust assemblies in vivo_revised final_shortenedAccepted author manuscript, 723 KB

http://pubs.acs.org/doi/10.1021/jacs.8b09582

Paul Lusby
- School of Chemistry - Personal Chair of Supramolecular Chemistry
- EaStCHEM
Person: Academic: Research Active

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Burke, B. P., Grantham, W., Burke, M. J., Nichol, G. S., Roberts, D., Renard, I., Hargreaves, R., Cawthorne, C., Archibald, S. J., & Lusby, P. J. (2018). Visualizing Kinetically Robust (Co4L6)-L-III Assemblies in Vivo: SPECT Imaging of the Encapsulated [Tc-99m]TcO4- Anion. Journal of the American Chemical Society, 140(49), 16877–16881. Advance online publication. https://doi.org/10.1021/jacs.8b09582

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abstract = "Non-covalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the gamma emitting [99mTc]TcO4− anion, under conditions compatible with in vivo administration. Subsequent SPECT imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer. ",

author = "Burke, {Benjamin P.} and William Grantham and Burke, {Michael J.} and Nichol, {Gary. S.} and David Roberts and Isaline Renard and Rebecca Hargreaves and Christopher Cawthorne and Archibald, {Stephen J.} and Lusby, {Paul J.}",

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AU - Burke, Michael J.

AU - Nichol, Gary. S.

AU - Roberts, David

AU - Renard, Isaline

AU - Hargreaves, Rebecca

AU - Cawthorne, Christopher

AU - Archibald, Stephen J.

AU - Lusby, Paul J.

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AB - Non-covalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the gamma emitting [99mTc]TcO4− anion, under conditions compatible with in vivo administration. Subsequent SPECT imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.

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DO - 10.1021/jacs.8b09582

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JO - Journal of the American Chemical Society

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Visualizing Kinetically Robust (Co4L6)-L-III Assemblies in Vivo: SPECT Imaging of the Encapsulated [Tc-99m]TcO4- Anion

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