Visualizing Kinetically Robust (Co4L6)-L-III Assemblies in Vivo: SPECT Imaging of the Encapsulated [Tc-99m]TcO4- Anion

Benjamin P. Burke, William Grantham, Michael J. Burke, Gary. S. Nichol, David Roberts, Isaline Renard, Rebecca Hargreaves, Christopher Cawthorne, Stephen J. Archibald, Paul J. Lusby

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Non-covalent encapsulation is an attractive approach for modifying the efficacy and physiochemical properties of both therapeutic and diagnostic species. Abiotic self-assembled constructs have shown promise, yet many hurdles between in vitro and (pre)clinical studies remain, not least the challenges associated with maintaining the macromolecular, hollow structure under nonequilibrium conditions. Using a kinetically robust CoIII4L6 tetrahedron we now show the feasibility of encapsulating the most widely used precursor in clinical nuclear diagnostic imaging, the gamma emitting [99mTc]TcO4− anion, under conditions compatible with in vivo administration. Subsequent SPECT imaging of the caged-anion reveals a marked change in the biodistribution compared to the thyroid-accumulating free oxo-anion, thus moving clinical applications of (metallo)supramolecular species a step closer.
Original languageEnglish
Pages (from-to)16877–16881
Number of pages5
JournalJournal of the American Chemical Society
Issue number49
Early online date28 Nov 2018
Publication statusPublished - 12 Dec 2018


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