Vitamin B1 analog benfotiamine prevents diabetes-induced diastolic dysfunction and heart failure through Akt/Pim-1-mediated survival pathway

Rajesh G Katare, Andrea Caporali, Atsuhiko Oikawa, Marco Meloni, Costanza Emanueli, Paolo Madeddu

Research output: Contribution to journalArticlepeer-review

Abstract

The increasing incidence of diabetes mellitus will result in a new epidemic of heart failure unless novel treatments able to halt diabetic cardiomyopathy early in its course are introduced. This study aimed to determine whether the activity of the Akt/Pim-1 signaling pathway is altered at critical stages of diabetic cardiomyopathy and whether supplementation with vitamin B1 analog benfotiamine (BFT) helps to sustain the above prosurvival mechanism, thereby preserving cardiomyocyte viability and function.
Original languageEnglish
Pages (from-to)294-305
Number of pages12
JournalCirculation: Heart failure
Volume3
Issue number2
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Analysis of Variance
  • Animals
  • Apoptosis
  • Blood Flow Velocity
  • Blotting, Western
  • Carrier Proteins
  • Cells, Cultured
  • Chromones
  • Diabetes Mellitus, Experimental
  • Diastole
  • Disease Models, Animal
  • Enzyme-Linked Immunosorbent Assay
  • Fibrosis
  • Heart Failure
  • Immunohistochemistry
  • Mice
  • Microfilament Proteins
  • Morpholines
  • Oxidative Stress
  • Proto-Oncogene Proteins c-pim-1
  • Random Allocation
  • Reverse Transcriptase Polymerase Chain Reaction
  • STAT3 Transcription Factor
  • Signal Transduction
  • Thiamine
  • Up-Regulation

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