Abstract
This is a protocol for a Cochrane Review (Intervention). The objectives are as follows:
Our primary objectives are to determine whether vitamin D supplementation reduces the risk of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) requiring systemic corticosteroids, antibiotics or both.
Our secondary objectives are to evaluate the impact of vitamin D supplementation on other effectiveness outcomes, including severe AECOPD, i.e. those requiring emergency department (ED) attendance or hospitalisation, moderate AECOPD, study‐defined AECOPD, adverse events, death, symptom control, industrial absenteeism, self‐reported short‐acting bronchodilator use, quality of life; physiological and biochemical, including lung function, exercise tolerance, muscle strength, biomarkers of inflammation, cost‐effectiveness and safety in people with COPD.
Our primary objectives are to determine whether vitamin D supplementation reduces the risk of acute exacerbations of chronic obstructive pulmonary disease (AECOPD) requiring systemic corticosteroids, antibiotics or both.
Our secondary objectives are to evaluate the impact of vitamin D supplementation on other effectiveness outcomes, including severe AECOPD, i.e. those requiring emergency department (ED) attendance or hospitalisation, moderate AECOPD, study‐defined AECOPD, adverse events, death, symptom control, industrial absenteeism, self‐reported short‐acting bronchodilator use, quality of life; physiological and biochemical, including lung function, exercise tolerance, muscle strength, biomarkers of inflammation, cost‐effectiveness and safety in people with COPD.
| Original language | English |
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| Journal | Cochrane Library |
| DOIs | |
| Publication status | Published - 25 Mar 2019 |