What chickens might tell us about the MHC class II system

Aimée Parker, Jim Kaufman

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Almost all knowledge about the structure and function of MHC class II molecules outside of mammals comes from work with chickens. Most of the genes implicated in the class II system are present in chickens, so it is likely that the machinery of antigen processing and peptide-loading is similar to mammals. However, there is only one isotype (lineage) of classical class II genes, with one monomorphic DR-like BLA gene and two polymorphic BLB genes, located near one DMA and two DMB genes. The DMB2 and BLB2 genes are widely expressed at high levels, whereas the DMB1 and BLB1 genes are only expressed at highest levels in spleen and intestine, suggesting the possibility of two class II systems in chickens.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalCurrent Opinion in Immunology
Volume46
Early online date21 Apr 2017
DOIs
Publication statusPublished - 1 Jun 2017

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