Projects per year
allowed many studies to provide novel mechanistic insights into certain brain pathologies, albeit at a still unsatisfying resolution, with masking of lowly expressed genes and of regulatory elements in different cell types. The recent rapid evolution of single cell technologies has now allowed researchers to shed light on human pathologies at a previously unreached resolution revealing
further insights into pathological mechanisms that will open the way for development of new strategies for therapies. In this review, we will give an overview of the incremental information that single cell technologies have given us for human white matter pathologies, summarize which single cell technologies are available and speculate where these novel approaches may lead us for pathological assessment in the future.
ECAT-Plus: Unravelling the regulatory mechanisms underlying expression of COL5A1 in human cornea in health and disease
Whyte, M., Acosta, J., Baillie, K., Bickmore, W., Digard, P., Dockrell, D., Drake, A., Dzierzak, E., Forbes, S., Gilbert, N., Granneman, S., Hardingham, G., Henderson, N., Hor, K., Jackson, I., Jackson, A., Kitto, L., McColl, B., Millar, F., Mustafa, Z., Myant, K., Parkinson, N., Pollard, S., Robertson, N., Rossi, A., Salman, R., Savill, J., Tollervey, D., Vitart, V., Walmsley, S., Williams, A., Wood, W. & Zamoyska, R.
1/08/17 → 31/07/23