White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

ONDRI Investigators; Daniela Cristina Carvalho de Abreu; Frederico Pieruccini-Faria; Yanina Sarquis-Adamson; Alanna Black; Julia Fraser; Karen Van Ooteghem; Benjamin Cornish; David Grimes; Mandar Jog; Mario Masellis; Thomas Steeves; Nuwan Nanayakkara; Joel Ramirez; Christopher Scott; Melissa Holmes; Miracle Ozzoude; Courtney Berezuk; Sean Symons; Seyyed Mohammad Hassan Haddad; Stephen R Arnott; Malcolm Binns; Stephen Strother; Derek Beaton; Kelly Sunderland; Athena Theyers; Brian Tan; Mojdeh Zamyadi; Brian Levine; Joseph B Orange; Angela C Roberts; Wendy Lou; Sujeevini Sujanthan; David P Breen; Connie Marras; Donna Kwan; Sabrina Adamo; Alicia Peltsch; Angela K Troyer; Sandra E Black; Paula M McLaughlin; Anthony E Lang; William McIlroy; Robert Bartha; Manuel Montero-Odasso

doi:10.1111/ene.15692

White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

ONDRI Investigators, Daniela Cristina Carvalho de Abreu, Frederico Pieruccini-Faria, Yanina Sarquis-Adamson, Alanna Black, Julia Fraser, Karen Van Ooteghem, Benjamin Cornish, David Grimes, Mandar Jog, Mario Masellis, Thomas Steeves, Nuwan Nanayakkara, Joel Ramirez, Christopher Scott, Melissa Holmes, Miracle Ozzoude, Courtney Berezuk, Sean Symons, Seyyed Mohammad Hassan HaddadStephen R Arnott, Malcolm Binns, Stephen Strother, Derek Beaton, Kelly Sunderland, Athena Theyers, Brian Tan, Mojdeh Zamyadi, Brian Levine, Joseph B Orange, Angela C Roberts, Wendy Lou, Sujeevini Sujanthan, David P Breen, Connie Marras, Donna Kwan, Sabrina Adamo, Alicia Peltsch, Angela K Troyer, Sandra E Black, Paula M McLaughlin, Anthony E Lang, William McIlroy, Robert Bartha, Manuel Montero-Odasso

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Abstract / Description of output

BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.

OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.

METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.

RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (p<0.05). Also, total WMH burden predicted the decline of executive function (p<0.05). Occipital WMH volumes also predicted decline in global cognition, visuomotor-attention and visuospatial-memory declines (p<0.05). WMH volumes at baseline did not predict motor decline.

CONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.

Original language	English
Journal	European Journal of Neurology
Early online date	24 Jan 2023
DOIs	https://doi.org/10.1111/ene.15692
Publication status	E-pub ahead of print - 24 Jan 2023

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Euro J of Neurology - 2023 - Carvalho de Abreu - White matter hyperintensity burden predicts cognitive but not motorAccepted author manuscript, 530 KBLicence: Creative Commons: Attribution (CC-BY)

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ONDRI Investigators, Carvalho de Abreu, D. C., Pieruccini-Faria, F., Sarquis-Adamson, Y., Black, A., Fraser, J., Van Ooteghem, K., Cornish, B., Grimes, D., Jog, M., Masellis, M., Steeves, T., Nanayakkara, N., Ramirez, J., Scott, C., Holmes, M., Ozzoude, M., Berezuk, C., Symons, S., ... Montero-Odasso, M. (2023). White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI. European Journal of Neurology. Advance online publication. https://doi.org/10.1111/ene.15692

@article{3749d9a47e934aa59842034820dc88f9,

title = "White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI",

abstract = "BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (p<0.05). Also, total WMH burden predicted the decline of executive function (p<0.05). Occipital WMH volumes also predicted decline in global cognition, visuomotor-attention and visuospatial-memory declines (p<0.05). WMH volumes at baseline did not predict motor decline.CONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.",

author = "{ONDRI Investigators} and {Carvalho de Abreu}, {Daniela Cristina} and Frederico Pieruccini-Faria and Yanina Sarquis-Adamson and Alanna Black and Julia Fraser and {Van Ooteghem}, Karen and Benjamin Cornish and David Grimes and Mandar Jog and Mario Masellis and Thomas Steeves and Nuwan Nanayakkara and Joel Ramirez and Christopher Scott and Melissa Holmes and Miracle Ozzoude and Courtney Berezuk and Sean Symons and {Mohammad Hassan Haddad}, Seyyed and Arnott, {Stephen R} and Malcolm Binns and Stephen Strother and Derek Beaton and Kelly Sunderland and Athena Theyers and Brian Tan and Mojdeh Zamyadi and Brian Levine and Orange, {Joseph B} and Roberts, {Angela C} and Wendy Lou and Sujeevini Sujanthan and Breen, {David P} and Connie Marras and Donna Kwan and Sabrina Adamo and Alicia Peltsch and Troyer, {Angela K} and Black, {Sandra E} and McLaughlin, {Paula M} and Lang, {Anthony E} and William McIlroy and Robert Bartha and Manuel Montero-Odasso",

year = "2023",

month = jan,

day = "24",

doi = "10.1111/ene.15692",

language = "English",

journal = "European Journal of Neurology",

issn = "1351-5101",

publisher = "Wiley-Blackwell",

}

ONDRI Investigators, Carvalho de Abreu, DC, Pieruccini-Faria, F, Sarquis-Adamson, Y, Black, A, Fraser, J, Van Ooteghem, K, Cornish, B, Grimes, D, Jog, M, Masellis, M, Steeves, T, Nanayakkara, N, Ramirez, J, Scott, C, Holmes, M, Ozzoude, M, Berezuk, C, Symons, S, Mohammad Hassan Haddad, S, Arnott, SR, Binns, M, Strother, S, Beaton, D, Sunderland, K, Theyers, A, Tan, B, Zamyadi, M, Levine, B, Orange, JB, Roberts, AC, Lou, W, Sujanthan, S, Breen, DP, Marras, C, Kwan, D, Adamo, S, Peltsch, A, Troyer, AK, Black, SE, McLaughlin, PM, Lang, AE, McIlroy, W, Bartha, R & Montero-Odasso, M 2023, 'White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI', European Journal of Neurology. https://doi.org/10.1111/ene.15692

TY - JOUR

T1 - White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

AU - ONDRI Investigators

AU - Carvalho de Abreu, Daniela Cristina

AU - Pieruccini-Faria, Frederico

AU - Sarquis-Adamson, Yanina

AU - Black, Alanna

AU - Fraser, Julia

AU - Van Ooteghem, Karen

AU - Cornish, Benjamin

AU - Grimes, David

AU - Jog, Mandar

AU - Masellis, Mario

AU - Steeves, Thomas

AU - Nanayakkara, Nuwan

AU - Ramirez, Joel

AU - Scott, Christopher

AU - Holmes, Melissa

AU - Ozzoude, Miracle

AU - Berezuk, Courtney

AU - Symons, Sean

AU - Mohammad Hassan Haddad, Seyyed

AU - Arnott, Stephen R

AU - Binns, Malcolm

AU - Strother, Stephen

AU - Beaton, Derek

AU - Sunderland, Kelly

AU - Theyers, Athena

AU - Tan, Brian

AU - Zamyadi, Mojdeh

AU - Levine, Brian

AU - Orange, Joseph B

AU - Roberts, Angela C

AU - Lou, Wendy

AU - Sujanthan, Sujeevini

AU - Breen, David P

AU - Marras, Connie

AU - Kwan, Donna

AU - Adamo, Sabrina

AU - Peltsch, Alicia

AU - Troyer, Angela K

AU - Black, Sandra E

AU - McLaughlin, Paula M

AU - Lang, Anthony E

AU - McIlroy, William

AU - Bartha, Robert

AU - Montero-Odasso, Manuel

PY - 2023/1/24

Y1 - 2023/1/24

N2 - BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (p<0.05). Also, total WMH burden predicted the decline of executive function (p<0.05). Occipital WMH volumes also predicted decline in global cognition, visuomotor-attention and visuospatial-memory declines (p<0.05). WMH volumes at baseline did not predict motor decline.CONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.

AB - BACKGROUND: The pathophysiology of Parkinson's disease (PD) negatively affects brain network connectivity, and in the presence of brain white matter hyperintensities (WMH) cognitive and motor impairments seem to be aggravated. However, the role of WMH in predicting accelerating symptom worsening remains controversial.OBJECTIVE: To investigate whether location and segmental brain WMH burden at baseline predicts cognitive and motor declines in PD after 2 years.METHODS: 98 older adults followed longitudinally from Ontario Neurodegenerative Diseases Research Initiative (ONDRI) with PD of 3-8 years in duration were included. Percentages of WMH volumes at baseline were calculated by location (deep and periventricular) and by brain regions (frontal, temporal, parietal, occipital lobes, and basal ganglia+thalamus). Cognitive and motor changes were assessed from baseline to 2-year follow-up. Specifically, global cognition, attention, executive function, memory, visuospatial abilities, and language were assessed as were motor symptoms evaluated using MDS-UPDRS Part III, spatial-temporal gait variables, Freezing of Gait questionnaire and Activities-Specific Balance Confidence Scale.RESULTS: Regression analysis adjusted for potential confounders showed that total and periventricular WMH at baseline predicted decline in global cognition (p<0.05). Also, total WMH burden predicted the decline of executive function (p<0.05). Occipital WMH volumes also predicted decline in global cognition, visuomotor-attention and visuospatial-memory declines (p<0.05). WMH volumes at baseline did not predict motor decline.CONCLUSION: WMH burden at baseline predicted only cognitive decline in PD. The motor decline observed after 2-years in these participants with early to mid-stage PD is probably related to the primary neurodegenerative process more than comorbid WM pathology.

U2 - 10.1111/ene.15692

DO - 10.1111/ene.15692

M3 - Article

C2 - 36692250

SN - 1351-5101

JO - European Journal of Neurology

JF - European Journal of Neurology

ER -

White matter hyperintensity burden predicts cognitive but not motor decline in Parkinson's disease. Results from the ONDRI

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