White matter integrity in individuals at high genetic risk of bipolar disorder

Emma Sprooten; Jessika E Sussmann; April Clugston; Anna Peel; James McKirdy; T William J Moorhead; Seonaid Anderson; Allen J Shand; Stephen Giles; Mark E Bastin; Jeremy Hall; Eve C Johnstone; Stephen M Lawrie; Andrew M McIntosh

doi:10.1016/j.biopsych.2011.01.021

White matter integrity in individuals at high genetic risk of bipolar disorder

Emma Sprooten, Jessika E Sussmann, April Clugston, Anna Peel, James McKirdy, T William J Moorhead, Seonaid Anderson, Allen J Shand, Stephen Giles, Mark E Bastin, Jeremy Hall, Eve C Johnstone, Stephen M Lawrie, Andrew M McIntosh

Research output: Contribution to journal › Article › peer-review

Abstract

Bipolar disorder is a familial psychiatric disorder associated with reduced white matter integrity, but it is not clear whether such abnormalities are present in young unaffected relatives and, if so, whether they have behavioral correlates. We investigated with whole brain diffusion tensor imaging whether increased genetic risk for bipolar disorder is associated with reductions in white matter integrity and whether these reductions are associated with cyclothymic temperament.

Original language	English
Pages (from-to)	350-356
Number of pages	7
Journal	Biological Psychiatry
Volume	70
Issue number	4
DOIs	https://doi.org/10.1016/j.biopsych.2011.01.021
Publication status	Published - 2011

Keywords / Materials (for Non-textual outputs)

Bipolar disorder
cyclothymia
diffusion tensor imaging (DTI)
endophenotypes
high risk

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10.1016/j.biopsych.2011.01.021

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Sprooten, E., Sussmann, J. E., Clugston, A., Peel, A., McKirdy, J., Moorhead, T. W. J., Anderson, S., Shand, A. J., Giles, S., Bastin, M. E., Hall, J., Johnstone, E. C., Lawrie, S. M., & McIntosh, A. M. (2011). White matter integrity in individuals at high genetic risk of bipolar disorder. Biological Psychiatry, 70(4), 350-356. https://doi.org/10.1016/j.biopsych.2011.01.021

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abstract = "Bipolar disorder is a familial psychiatric disorder associated with reduced white matter integrity, but it is not clear whether such abnormalities are present in young unaffected relatives and, if so, whether they have behavioral correlates. We investigated with whole brain diffusion tensor imaging whether increased genetic risk for bipolar disorder is associated with reductions in white matter integrity and whether these reductions are associated with cyclothymic temperament.",

keywords = "Bipolar disorder, cyclothymia, diffusion tensor imaging (DTI), endophenotypes, high risk",

author = "Emma Sprooten and Sussmann, \{Jessika E\} and April Clugston and Anna Peel and James McKirdy and Moorhead, \{T William J\} and Seonaid Anderson and Shand, \{Allen J\} and Stephen Giles and Bastin, \{Mark E\} and Jeremy Hall and Johnstone, \{Eve C\} and Lawrie, \{Stephen M\} and McIntosh, \{Andrew M\}",

year = "2011",

doi = "10.1016/j.biopsych.2011.01.021",

language = "English",

volume = "70",

pages = "350--356",

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T1 - White matter integrity in individuals at high genetic risk of bipolar disorder

AU - Sprooten, Emma

AU - Sussmann, Jessika E

AU - Clugston, April

AU - Peel, Anna

AU - McKirdy, James

AU - Moorhead, T William J

AU - Anderson, Seonaid

AU - Shand, Allen J

AU - Giles, Stephen

AU - Bastin, Mark E

AU - Hall, Jeremy

AU - Johnstone, Eve C

AU - Lawrie, Stephen M

AU - McIntosh, Andrew M

PY - 2011

Y1 - 2011

N2 - Bipolar disorder is a familial psychiatric disorder associated with reduced white matter integrity, but it is not clear whether such abnormalities are present in young unaffected relatives and, if so, whether they have behavioral correlates. We investigated with whole brain diffusion tensor imaging whether increased genetic risk for bipolar disorder is associated with reductions in white matter integrity and whether these reductions are associated with cyclothymic temperament.

AB - Bipolar disorder is a familial psychiatric disorder associated with reduced white matter integrity, but it is not clear whether such abnormalities are present in young unaffected relatives and, if so, whether they have behavioral correlates. We investigated with whole brain diffusion tensor imaging whether increased genetic risk for bipolar disorder is associated with reductions in white matter integrity and whether these reductions are associated with cyclothymic temperament.

KW - Bipolar disorder

KW - cyclothymia

KW - diffusion tensor imaging (DTI)

KW - endophenotypes

KW - high risk

U2 - 10.1016/j.biopsych.2011.01.021

DO - 10.1016/j.biopsych.2011.01.021

M3 - Article

C2 - 21429475

VL - 70

SP - 350

EP - 356

JO - Biological Psychiatry

JF - Biological Psychiatry

IS - 4

ER -

White matter integrity in individuals at high genetic risk of bipolar disorder

Abstract

Keywords / Materials (for Non-textual outputs)

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