Projects per year
Abstract
Processing speed is an important cognitive function that is compromised in psychiatric illness (e.g., schizophrenia, depression) and old age; it shares genetic background with complex cognition (e.g., working memory, reasoning). To find genes influencing speed we performed a genome-wide association scan in up to three cohorts: Brisbane (mean age 16 years; N = 1659); LBC1936 (mean age 70 years, N = 992); LBC1921 (mean age 82 years, N = 307), and; HBCS (mean age 64 years, N =1080). Meta-analysis of the common measures highlighted various suggestively significant (p < 1.21 × 10⁻⁵) SNPs and plausible candidate genes (e.g., TRIB3). A biological pathways analysis of the speed factor identified two common pathways from the KEGG database (cell junction, focal adhesion) in two cohorts, while a pathway analysis linked to the GO database revealed common pathways across pairs of speed measures (e.g., receptor binding, cellular metabolic process). These highlighted genes and pathways will be able to inform future research, including results for psychiatric disease.
Original language | English |
---|---|
Pages (from-to) | 193-202 |
Number of pages | 10 |
Journal | Biological Psychology |
Volume | 86 |
Issue number | 3 |
DOIs | |
Publication status | Published - Mar 2011 |
Keywords / Materials (for Non-textual outputs)
- Information processing speed
- Cognitive ability
- Genes
- Biological pathways
Fingerprint
Dive into the research topics of 'Whole genome association scan for genetic polymorphisms influencing information processing speed'. Together they form a unique fingerprint.Projects
- 6 Finished
-
Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
8/06/11 → 7/03/15
Project: Research
-
-
A genome wide association study of non pathological cognitive ageing
Deary, I. (Principal Investigator), Porteous, D. (Co-investigator) & Tenesa, A. (Co-investigator)
1/09/08 → 31/08/10
Project: Research