Why “sex as a biological variable” conflicts with precision medicine initiatives

Marina Dimarco; Helen Zhao; Marion Boulicault; Sarah s. Richardson

doi:10.1016/j.xcrm.2022.100550

Why “sex as a biological variable” conflicts with precision medicine initiatives

Marina Dimarco, Helen Zhao, Marion Boulicault, Sarah s. Richardson

School of Philosophy, Psychology and Language Sciences

Research output: Contribution to journal › Comment/debate › peer-review

Abstract

Policies that require male-female sex comparisons in all areas of biomedical research conflict with the goal of improving health outcomes through context-sensitive individualization of medical care. Sex, like race, requires a rigorous, contextual approach in precision medicine. A “sex contextualist” approach to gender-inclusive medicine better aligns with this aim.

Original language	English
Pages (from-to)	100550
Journal	Cell Reports Medicine
Volume	3
Issue number	4
Early online date	19 Apr 2022
DOIs	https://doi.org/10.1016/j.xcrm.2022.100550
Publication status	Published - Apr 2022

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title = "Why “sex as a biological variable” conflicts with precision medicine initiatives",

abstract = "Policies that require male-female sex comparisons in all areas of biomedical research conflict with the goal of improving health outcomes through context-sensitive individualization of medical care. Sex, like race, requires a rigorous, contextual approach in precision medicine. A “sex contextualist” approach to gender-inclusive medicine better aligns with this aim.",

author = "Marina Dimarco and Helen Zhao and Marion Boulicault and Richardson, {Sarah s.}",

note = "Thank you to the GenderSci Lab at Harvard University, especially Katharine M.N. Lee, Alexander Borsa, Benjamin Maldonado, Meg Perret, and Heather Shattuck-Heidorn, for discussions that contributed to the development of this commentary.",

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AU - Zhao, Helen

AU - Boulicault, Marion

AU - Richardson, Sarah s.

N1 - Thank you to the GenderSci Lab at Harvard University, especially Katharine M.N. Lee, Alexander Borsa, Benjamin Maldonado, Meg Perret, and Heather Shattuck-Heidorn, for discussions that contributed to the development of this commentary.

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N2 - Policies that require male-female sex comparisons in all areas of biomedical research conflict with the goal of improving health outcomes through context-sensitive individualization of medical care. Sex, like race, requires a rigorous, contextual approach in precision medicine. A “sex contextualist” approach to gender-inclusive medicine better aligns with this aim.

AB - Policies that require male-female sex comparisons in all areas of biomedical research conflict with the goal of improving health outcomes through context-sensitive individualization of medical care. Sex, like race, requires a rigorous, contextual approach in precision medicine. A “sex contextualist” approach to gender-inclusive medicine better aligns with this aim.

U2 - 10.1016/j.xcrm.2022.100550

DO - 10.1016/j.xcrm.2022.100550

M3 - Comment/debate

SN - 2666-3791

VL - 3

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JO - Cell Reports Medicine

JF - Cell Reports Medicine

IS - 4

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Why “sex as a biological variable” conflicts with precision medicine initiatives

Abstract

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