Wilms' tumour 1 (WT1) in development, homeostasis and disease

Nicholas D Hastie

Research output: Contribution to journalReview articlepeer-review

Abstract

The study of genes mutated in human disease often leads to new insights into biology as well as disease mechanisms. One such gene is Wilms' tumour 1 (WT1), which plays multiple roles in development, tissue homeostasis and disease. In this Primer, I summarise how this multifaceted gene functions in various mammalian tissues and organs, including the kidney, gonads, heart and nervous system. This is followed by a discussion of our current understanding of the molecular mechanisms by which WT1 and its two major isoforms regulate these processes at the transcriptional and post-transcriptional levels.

Original languageEnglish
Pages (from-to)2862-2872
Number of pages11
JournalDevelopment
Volume144
Issue number16
DOIs
Publication statusPublished - 15 Aug 2017

Keywords

  • Journal Article
  • Review

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