Wilms' tumour gene and function

N D Hastie

Research output: Contribution to journalArticlepeer-review

Abstract

The Wilms' tumour gene, WT1, encodes a protein with four zinc fingers that is probably a transcription factor. In humans, WT1 mutations can lead to childhood kidney tumours and to developmental defects of the kidney and gonad. The WT1 gene may have a role in the mesenchyme to epithelial switch in a range of mesodermally derived tissues. Furthermore, growth-factor genes may be targets for repression by the WT1 protein during development. WT1 is the first example of a tumour-suppressor gene with a specific developmental role.

Original languageEnglish
Pages (from-to)408-13
Number of pages6
JournalCurrent Opinion in Genetics and Development
Volume3
Issue number3
Publication statusPublished - Jun 1993

Keywords

  • Animals
  • DNA-Binding Proteins
  • Genes, Wilms Tumor
  • Humans
  • WT1 Proteins
  • Zinc Fingers

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