Wilms' tumour: reconciling genetics and biology

V Van Heyningen, N D Hastie

Research output: Contribution to journalArticlepeer-review

Abstract

Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.

Original languageEnglish
Pages (from-to)16-21
Number of pages6
JournalTrends in Genetics
Volume8
Issue number1
Publication statusPublished - Jan 1992

Keywords

  • Abnormalities, Multiple
  • Aniridia
  • Chromosomes, Human, Pair 11
  • Cryptorchidism
  • DNA-Binding Proteins
  • Female
  • Gene Expression Regulation, Developmental
  • Gene Expression Regulation, Neoplastic
  • Genes, Wilms Tumor
  • Gonads
  • Humans
  • Hypospadias
  • Kidney
  • Kidney Neoplasms
  • Male
  • Oncogenes
  • Sequence Deletion
  • Syndrome
  • Transcription Factors
  • WT1 Proteins
  • Wilms Tumor
  • Zinc Fingers

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