Abstract
Wilms' tumour, a paediatric malignancy of the kidney, is a striking example of the relationship between aberrant development and cancer. Several different genetic loci have been implicated in the aetiology of the tumour; genomic imprinting also plays a role. One Wilms' tumour predisposition gene (WT1), encoding a zinc finger protein, is expressed in a limited set of tissues, including developing nephrons and gonads. The biology and genetics of Wilms' tumour underline the developmental relationship between kidneys and gonads.
| Original language | English |
|---|---|
| Pages (from-to) | 16-21 |
| Number of pages | 6 |
| Journal | Trends in Genetics |
| Volume | 8 |
| Issue number | 1 |
| Publication status | Published - Jan 1992 |
Keywords / Materials (for Non-textual outputs)
- Abnormalities, Multiple
- Aniridia
- Chromosomes, Human, Pair 11
- Cryptorchidism
- DNA-Binding Proteins
- Female
- Gene Expression Regulation, Developmental
- Gene Expression Regulation, Neoplastic
- Genes, Wilms Tumor
- Gonads
- Humans
- Hypospadias
- Kidney
- Kidney Neoplasms
- Male
- Oncogenes
- Sequence Deletion
- Syndrome
- Transcription Factors
- WT1 Proteins
- Wilms Tumor
- Zinc Fingers