Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer

Martin Muñoz-Lopez, Pedro P Medina, Jose L Garcia-Perez

Research output: Contribution to journalArticlepeer-review

Abstract

Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.

Original languageEnglish
Pages (from-to)405-7
Number of pages3
JournalCancer Cell
Volume24
Issue number4
DOIs
Publication statusPublished - 14 Oct 2013

Keywords

  • Animals
  • Ataxia Telangiectasia Mutated Proteins
  • BRCA1 Protein
  • DNA Methylation
  • Heterochromatin
  • Humans
  • Male
  • Phosphoprotein Phosphatases

Fingerprint

Dive into the research topics of 'Wiping DNA methylation: Wip1 regulates genomic fluidity on cancer'. Together they form a unique fingerprint.

Cite this