Wip1 phosphatase plays an important role in cancer by inactivating p53 and INK4a/ARF pathways. In this issue of Cancer Cell, Filipponi and colleagues further connect the oncogenic role of Wip1 with heterochromatin dynamics, transposable element expression, and a mutation-prone environment that may enhance heterogeneity and ultimately contribute to tumor evolution.
- Ataxia Telangiectasia Mutated Proteins
- BRCA1 Protein
- DNA Methylation
- Phosphoprotein Phosphatases