Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice

Deanna D Nguyen; Marc-Andre Wurbel; Jeremy A Goettel; Michelle A Eston; Osub S Ahmed; Romela Marin; Elisa K Boden; Eduardo J Villablanca; Helena Paidassi; Vineet Ahuja; Hans-Christian Reinecker; Edda Fiebiger; Adam Lacy-Hulbert; Bruce H Horwitz; J Rodrigo Mora; Scott B Snapper

doi:10.1053/j.gastro.2012.06.008

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice

Deanna D Nguyen, Marc-Andre Wurbel, Jeremy A Goettel, Michelle A Eston, Osub S Ahmed, Romela Marin, Elisa K Boden, Eduardo J Villablanca, Helena Paidassi, Vineet Ahuja, Hans-Christian Reinecker, Edda Fiebiger, Adam Lacy-Hulbert, Bruce H Horwitz, J Rodrigo Mora, Scott B Snapper

School of Regeneration and Repair

Research output: Contribution to journal › Article › peer-review

Abstract

Immunodeficiency and autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton. Development of colitis in WASP-deficient mice requires lymphocytes; transfer of T cells is sufficient to induce colitis in immunodeficient mice. We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system.

Original language	English
Pages (from-to)	719-29.e1-2
Journal	Gastroenterology
Volume	143
Issue number	3
DOIs	https://doi.org/10.1053/j.gastro.2012.06.008
Publication status	Published - Sept 2012

Keywords / Materials (for Non-textual outputs)

Adoptive Transfer
Animals
Antigens, CD
Antigens, CD11b
CD4-Positive T-Lymphocytes
Cell Proliferation
Cells, Cultured
Colitis
Colon
DNA-Binding Proteins
Dendritic Cells
Disease Models, Animal
Forkhead Transcription Factors
Immune Tolerance
Immunity, Innate
Immunity, Mucosal
Integrin alpha Chains
Interleukin-10
Intestinal Mucosa
Lymphocyte Activation
Mice
Mice, 129 Strain
Mice, Knockout
T-Lymphocytes, Regulatory
Time Factors
Transplantation Chimera
Wiskott-Aldrich Syndrome Protein

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10.1053/j.gastro.2012.06.008

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in miceAccepted author manuscript, 3.61 MB

http://www.gastrojournal.org/article/S0016-5085%2812%2900824-4/abstract

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Nguyen, D. D., Wurbel, M.-A., Goettel, J. A., Eston, M. A., Ahmed, O. S., Marin, R., Boden, E. K., Villablanca, E. J., Paidassi, H., Ahuja, V., Reinecker, H.-C., Fiebiger, E., Lacy-Hulbert, A., Horwitz, B. H., Mora, J. R., & Snapper, S. B. (2012). Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice. Gastroenterology, 143(3), 719-29.e1-2. https://doi.org/10.1053/j.gastro.2012.06.008

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title = "Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice",

abstract = "Immunodeficiency and autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton. Development of colitis in WASP-deficient mice requires lymphocytes; transfer of T cells is sufficient to induce colitis in immunodeficient mice. We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system.",

keywords = "Adoptive Transfer, Animals, Antigens, CD, Antigens, CD11b, CD4-Positive T-Lymphocytes, Cell Proliferation, Cells, Cultured, Colitis, Colon, DNA-Binding Proteins, Dendritic Cells, Disease Models, Animal, Forkhead Transcription Factors, Immune Tolerance, Immunity, Innate, Immunity, Mucosal, Integrin alpha Chains, Interleukin-10, Intestinal Mucosa, Lymphocyte Activation, Mice, Mice, 129 Strain, Mice, Knockout, T-Lymphocytes, Regulatory, Time Factors, Transplantation Chimera, Wiskott-Aldrich Syndrome Protein",

author = "Nguyen, \{Deanna D\} and Marc-Andre Wurbel and Goettel, \{Jeremy A\} and Eston, \{Michelle A\} and Ahmed, \{Osub S\} and Romela Marin and Boden, \{Elisa K\} and Villablanca, \{Eduardo J\} and Helena Paidassi and Vineet Ahuja and Hans-Christian Reinecker and Edda Fiebiger and Adam Lacy-Hulbert and Horwitz, \{Bruce H\} and Mora, \{J Rodrigo\} and Snapper, \{Scott B\}",

year = "2012",

month = sep,

doi = "10.1053/j.gastro.2012.06.008",

language = "English",

volume = "143",

pages = "719--29.e1--2",

journal = "Gastroenterology",

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publisher = "W.B. Saunders Company",

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Nguyen, DD, Wurbel, M-A, Goettel, JA, Eston, MA, Ahmed, OS, Marin, R, Boden, EK, Villablanca, EJ, Paidassi, H, Ahuja, V, Reinecker, H-C, Fiebiger, E, Lacy-Hulbert, A, Horwitz, BH, Mora, JR & Snapper, SB 2012, 'Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice', Gastroenterology, vol. 143, no. 3, pp. 719-29.e1-2. https://doi.org/10.1053/j.gastro.2012.06.008

TY - JOUR

T1 - Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice

AU - Nguyen, Deanna D

AU - Wurbel, Marc-Andre

AU - Goettel, Jeremy A

AU - Eston, Michelle A

AU - Ahmed, Osub S

AU - Marin, Romela

AU - Boden, Elisa K

AU - Villablanca, Eduardo J

AU - Paidassi, Helena

AU - Ahuja, Vineet

AU - Reinecker, Hans-Christian

AU - Fiebiger, Edda

AU - Lacy-Hulbert, Adam

AU - Horwitz, Bruce H

AU - Mora, J Rodrigo

AU - Snapper, Scott B

PY - 2012/9

Y1 - 2012/9

N2 - Immunodeficiency and autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton. Development of colitis in WASP-deficient mice requires lymphocytes; transfer of T cells is sufficient to induce colitis in immunodeficient mice. We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system.

AB - Immunodeficiency and autoimmune sequelae, including colitis, develop in patients and mice deficient in Wiskott-Aldrich syndrome protein (WASP), a hematopoietic cell-specific intracellular signaling molecule that regulates the actin cytoskeleton. Development of colitis in WASP-deficient mice requires lymphocytes; transfer of T cells is sufficient to induce colitis in immunodeficient mice. We investigated the interactions between innate and adaptive immune cells in mucosal regulation during development of T cell-mediated colitis in mice with WASP-deficient cells of the innate immune system.

KW - Adoptive Transfer

KW - Animals

KW - Antigens, CD

KW - Antigens, CD11b

KW - CD4-Positive T-Lymphocytes

KW - Cell Proliferation

KW - Cells, Cultured

KW - Colitis

KW - Colon

KW - DNA-Binding Proteins

KW - Dendritic Cells

KW - Disease Models, Animal

KW - Forkhead Transcription Factors

KW - Immune Tolerance

KW - Immunity, Innate

KW - Immunity, Mucosal

KW - Integrin alpha Chains

KW - Interleukin-10

KW - Intestinal Mucosa

KW - Lymphocyte Activation

KW - Mice

KW - Mice, 129 Strain

KW - Mice, Knockout

KW - T-Lymphocytes, Regulatory

KW - Time Factors

KW - Transplantation Chimera

KW - Wiskott-Aldrich Syndrome Protein

U2 - 10.1053/j.gastro.2012.06.008

DO - 10.1053/j.gastro.2012.06.008

M3 - Article

C2 - 22710191

SN - 1528-0012

VL - 143

SP - 719-29.e1-2

JO - Gastroenterology

JF - Gastroenterology

IS - 3

ER -

Wiskott-Aldrich syndrome protein deficiency in innate immune cells leads to mucosal immune dysregulation and colitis in mice

Abstract

Keywords / Materials (for Non-textual outputs)

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