Wnt/Myc interactions in intestinal cancer: partners in crime

Kevin Myant; Owen J Sansom

doi:10.1016/j.yexcr.2011.08.001

Wnt/Myc interactions in intestinal cancer: partners in crime

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.

Original language	English
Pages (from-to)	2725-31
Number of pages	7
Journal	Experimental Cell Research
Volume	317
Issue number	19
DOIs	https://doi.org/10.1016/j.yexcr.2011.08.001
Publication status	Published - 15 Nov 2011

Keywords / Materials (for Non-textual outputs)

Animals
Carcinoma
Cell Transformation, Neoplastic
Crime
Epistasis, Genetic
Genes, myc
Humans
Intestinal Neoplasms
Models, Biological
Wit and Humor as Topic
Wnt Proteins

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10.1016/j.yexcr.2011.08.001

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@article{1f12c0bd23eb41d1957b650b00356082,

title = "Wnt/Myc interactions in intestinal cancer: partners in crime",

abstract = "Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.",

keywords = "Animals, Carcinoma, Cell Transformation, Neoplastic, Crime, Epistasis, Genetic, Genes, myc, Humans, Intestinal Neoplasms, Models, Biological, Wit and Humor as Topic, Wnt Proteins",

author = "Kevin Myant and Sansom, {Owen J}",

year = "2011",

month = nov,

day = "15",

doi = "10.1016/j.yexcr.2011.08.001",

language = "English",

volume = "317",

pages = "2725--31",

journal = "Experimental Cell Research",

issn = "0014-4827",

publisher = "Academic Press",

number = "19",

}

TY - JOUR

T1 - Wnt/Myc interactions in intestinal cancer

T2 - partners in crime

AU - Myant, Kevin

AU - Sansom, Owen J

PY - 2011/11/15

Y1 - 2011/11/15

N2 - Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.

AB - Loss of the APC (adenomatous polyposis coli) gene in colorectal cancer leads to a rapid deregulation of TCF/LEF target genes. Of all these target genes, the transcription factor c-MYC appears the most critical. In this review we will discuss the interplay of Wnt and c-MYC signaling during intestinal homeostasis and transformation. Furthermore, we will discuss recent data showing that further deregulation of c-MYC levels during colorectal carcinogenesis may drive tumor progression. Moreover, understanding these additional control mechanisms may allow targeting of c-MYC during colorectal carcinogenesis.

KW - Animals

KW - Carcinoma

KW - Cell Transformation, Neoplastic

KW - Crime

KW - Epistasis, Genetic

KW - Genes, myc

KW - Humans

KW - Intestinal Neoplasms

KW - Models, Biological

KW - Wit and Humor as Topic

KW - Wnt Proteins

U2 - 10.1016/j.yexcr.2011.08.001

DO - 10.1016/j.yexcr.2011.08.001

M3 - Article

C2 - 21851818

SN - 0014-4827

VL - 317

SP - 2725

EP - 2731

JO - Experimental Cell Research

JF - Experimental Cell Research

IS - 19

ER -

Wnt/Myc interactions in intestinal cancer: partners in crime

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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