Wt1 in the kidney-a tale in mouse models

Derya Deniz Ozdemir; Peter Hohenstein

doi:10.1007/s00467-013-2673-7

Wt1 in the kidney-a tale in mouse models

Derya Deniz Ozdemir, Peter Hohenstein

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The WT1 gene was originally identified through its involvement in the development of Wilms tumours. The gene is characterized by a plethora of different isoforms with, in some cases, clearly different functions in transcriptional control and RNA metabolism. Many different mouse models for Wt1 have already been generated, and these are increasingly providing new information on the molecular roles of Wt1 in normal development and disease. In this review we discuss the different models that have been generated and what they have taught us about the role of Wt1 in the kidney.

Original language	English
Pages (from-to)	687-693
Journal	Pediatric Nephrology
Volume	29
Issue number	4
Early online date	18 Nov 2013
DOIs	https://doi.org/10.1007/s00467-013-2673-7
Publication status	Published - 18 Nov 2013

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10.1007/s00467-013-2673-7

http://link.springer.com/article/10.1007%2Fs00467-013-2673-7

Control of development and reproductive traits
Burdon, T., Argyle, D., Ashworth, C., Beard, P., Brunton, P., Burt, D., Clinton, M., Dunn, I., Farquharson, C., Headon, D., Hocking, P., Hohenstein, P., Hume, D., Jackson, I., McColl, B., McGrew, M., McLachlan, G., Sang, H., Summers, K. & Whitelaw, B.
BBSRC
1/04/12 → 31/03/17
Project: Research

Cite this

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Wt1 in the kidney-a tale in mouse models

Abstract

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Control of development and reproductive traits

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