WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi; Nicholas D Hastie

doi:10.1016/j.molcel.2010.01.010

WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi, Nicholas D Hastie

Research output: Contribution to journal › Article › peer-review

Abstract

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.

Original language	English
Pages (from-to)	153-5
Number of pages	3
Journal	Molecular Cell
Volume	37
Issue number	2
DOIs	https://doi.org/10.1016/j.molcel.2010.01.010
Publication status	Published - 2010

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10.1016/j.molcel.2010.01.010

http://www.cell.com/molecular-cell/retrieve/pii/S1097276510000377

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title = "WT1 the oncogene: a tale of death and HtrA",

abstract = "Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.",

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WT1 the oncogene: a tale of death and HtrA

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