WT1 the oncogene: a tale of death and HtrA

Abdelkader Essafi, Nicholas D Hastie

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Here, Hartkamp et al. (2010) identify WT1 as a novel bona fide substrate of the HtrA2/Omi mitochondrial protease and show that this reaction modulates WT1 antiapoptotic activity under cytotoxic stress. This supports an oncogenic function for WT1, with implications for novel chemotherapeutic avenues.
Original languageEnglish
Pages (from-to)153-5
Number of pages3
JournalMolecular Cell
Issue number2
Publication statusPublished - 2010


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