Abstract
Analysis of F2 and backcross animals has confirmed the X-chromosome linkage of Ags, the structural locus for mouse alpha-galactosidase. The position of Ags has been located in the X chromosome, 9 centimorgans from Mo, and the gene order is centromere-Hq-Bn-Ta-Mo-Ags. A variation in the developmental expression of alpha-galactosidase activity, inherited as an autosomal trait, has been characterized using recombinant inbred lines of mice. Among certain recombinant inbred lines, the variation appears to segregate as a single major locus.
| Original language | English |
|---|---|
| Pages (from-to) | 327-42 |
| Number of pages | 16 |
| Journal | Genetics |
| Volume | 88 |
| Issue number | 2 |
| Publication status | Published - Feb 1978 |
Keywords
- Animals
- Chromosome Mapping
- Chromosomes
- Crosses, Genetic
- Female
- Galactosidases
- Genes, Regulator
- Liver
- Male
- Mice
- Sex Chromosomes
- X Chromosome
- alpha-Galactosidase