X-ray structures and analysis of 11 cyclosporin derivatives complexed with cyclophilin A

J Kallen, V Mikol, P Taylor, M D Walkinshaw

Research output: Contribution to journalArticlepeer-review

Abstract

Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
Original languageEnglish
Pages (from-to)435-49
Number of pages15
JournalJournal of Molecular Biology
Volume283
Issue number2
Publication statusPublished - 1998

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