Abstract / Description of output
Eight new X-ray structures of different cyclophilin A/cyclosporin-derivative complexes are presented. These structures, combined with the existing three published cyclosporin complexes, provide a useful structural database for the analysis of protein-ligand interactions. The effect of small chemical differences on protein-ligand hydrogen-bonding, van der Waals interactions and water structure is presented.
Original language | English |
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Pages (from-to) | 435-49 |
Number of pages | 15 |
Journal | Journal of Molecular Biology |
Volume | 283 |
Issue number | 2 |
Publication status | Published - 1998 |