Xmrk in Medaka: A New Genetic Melanoma Model

E Elizabeth Patton, Rodney S. Nairn

Research output: Contribution to journalEditorialpeer-review

Abstract

Melanoma is the most lethal form of skin cancer, and its incidence is rising rapidly (Chin et al., 2006; Linos et al., 2009). Highly aggressive, metastatic melanoma is notoriously resistant to chemotherapy, and early detection is critical for surgical excision (Gray-Schopfer et al., 2007). A detailed knowledge of the cellular, molecular, and genetic events during melanoma progression is highly relevant to both diagnosis and the development of new therapies. Animal models, such as the one described in this issue by Schartl and colleagues, are important tools for identifying the genetic and environmental factors that contribute to melanoma development, as well as identifying and testing new therapeutic strategies.

Original languageEnglish
Pages (from-to)14-17
Number of pages5
JournalJournal of Investigative Dermatology
Volume130
Issue number1
DOIs
Publication statusPublished - Jan 2010

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