Y RNAs: recent developments

Adam E Hall, Carly Turnbull, Tamas Dalmay

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Non-coding RNAs have emerged as key regulators in diverse cellular processes. Y RNAs are ∼100-nucleotide-long non-coding RNAs that show high conservation in metazoans. Human Y RNAs are known to bind to the Ro60 and La proteins to form the Ro ribonucleoprotein complex. Their main biological function appears to be in mediating the initiation of chromosomal DNA replication, regulating the autoimmune protein Ro60, and generating smaller RNA fragments following cellular stress, although the precise molecular mechanisms underlying these functions remain elusive. Here, we aim to review the most recent literature on Y RNAs and gain insight into the function of these intriguing molecules.

Original languageEnglish
Pages (from-to)103-10
Number of pages8
JournalBioMolecular Concepts
Volume4
Issue number2
DOIs
Publication statusPublished - Apr 2013

Keywords

  • Animals
  • Autoantigens
  • DNA
  • DNA Replication
  • Humans
  • Phosphoproteins
  • RNA, Small Cytoplasmic
  • RNA, Untranslated
  • Ribonucleoproteins

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