Yeast: One cell, one reference sequence, many genomes?

Erika Szymanski, Niki Vermeulen, Mark Wong

Research output: Contribution to journalArticlepeer-review

Abstract

The genome of Saccharomyces cerevisiae – brewer’s or baker’s yeast – was the first eukaryotic genome to be sequenced in 1996. The identity of that yeast genome has been not just a product of sequencing, but also of its use after sequencing and particularly of its mobilization in scientific literature. We ask “what is the yeast genome?” as an empirical question by investigating “the yeast genome” as a discursive entity. Analyzing publications that followed sequencing points to several “yeast genomes” existing side-by-side: genomes as physical molecules, digital texts, and a historic event. Resolving this unified-yet-multiple “genome” helps make sense of contemporary developments in yeast genomics such as the synthetic yeast project, in which apparently “the same” genome occupies multiple roles and locations, and points to the utility of examining specific non-human genomes independent of the Human Genome Project.
Original languageEnglish
Pages (from-to)430-450
Number of pages21
JournalNew Genetics and Society
Volume38
Issue number4
Early online date14 Oct 2019
DOIs
Publication statusPublished - 2019

Keywords

  • genomics
  • yeast
  • discourse analysis

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