Zoonotic causes of febrile illness in malaria endemic countries: a systematic review

Jo E B Halliday, Manuela Carugati, Michael Snavely, Kathryn Allen , Julia Beamesderfer, Georgia Ladbury, Deborah Hoyle, Paul Holland, John A. Crump, Sarah Cleaveland, Matthew P. Rubach

Research output: Contribution to journalReview articlepeer-review

Abstract / Description of output

Fever is one of the most common reasons for healthcare seeking
globally and the majority of human pathogens are zoonotic. We conducted a
systematic review to describe the occurrence and distribution of zoonotic
causes of human febrile illness reported in malaria endemic countries.
Articles included in the review yielded data from 53 (48·2%) of 110
malaria endemic countries. The 244 articles included described diagnosis
of 30 zoonoses in febrile people. The majority of zoonoses were bacterial
(n=17), with viruses (n=9), protozoa (n=3) and helminths (n=1) also
identified. Leptospira spp. and nontyphoidal Salmonella serovars were the
most frequently reported pathogens. Despite evidence of profound data
gaps, this review reveals widespread distribution of a diverse range of
zoonotic causes of febrile illness. Greater understanding of the
epidemiology of zoonoses in different settings is needed to improve
awareness and management of the multiple zoonotic causes of febrile
Original languageEnglish
Pages (from-to)e27-e37
JournalThe Lancet Infectious Diseases
Issue number2
Early online date29 Jan 2020
Publication statusPublished - Feb 2020


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