Edinburgh Research Explorer

Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics

Dataset

Related Edinburgh Organisations

PublisherEdinburgh DataShare
Date made available26 Feb 2019
Geographical coverageUNITED KINGDOM,UK

Abstract

This dataset contains summary statistics for the epigenome-wide association studies (EWASs) performed to ascertain the feasibility of profiling DNA methylation using dried blood spot (DBS) DNA from Generation Scotland participants' blood samples that were stored on Whatman FTA cards and the comparability of these DBS methylation profiles with those obtained from paired blood samples stored in EDTA tubes. Paired DBS and EDTA tube blood samples were profiled using the Illumina 450K methylation array and EWASs for age and smoking performed to assess (i) whether loci previously found to be associated with these traits were identified in the DBS samples and (ii) whether the method of storing the blood sample (EDTA tube or Whatman FTA card) moderated the relationship between these traits and DNA methylation. The data is described fully in the associated pre-print, which is available on bioRxiv (https://doi.org/10.1101/546606).

Data Citation

Walker, Rosie; MacGillivray, Louise; McCafferty, Sarah; Wrobel, Nicola; Kerr, Shona; Morris, Stewart; Campbell, Archie; McIntosh, Andrew; Porteous, David; Evans, Kathryn. (2019). Comparison of DNA methylation profiles from Generation Scotland blood samples stored on Whatman FTA cards and in EDTA tubes: EWAS summary statistics, [dataset]. University of Edinburgh. School of Molecular, Genetic and Population Health Sciences. Institute of Genetics and Molecular Medicine. https://doi.org/10.7488/ds/2502.

ID: 80707238