Edinburgh Research Explorer
  1. 2020
  2. Cerebrospinal fluid cytotoxicity in amyotrophic lateral sclerosis: a systematic review of in vitro studies

    Kwong, K. C. N. K., Gregory, J. M., Pal, S., Chandran, S. & Mehta, A. R., 6 Aug 2020, In : Brain Communications.

    Research output: Contribution to journalArticle

  3. Pre-natal manifestation of systemic developmental abnormalities in spinal muscular atrophy

    Motyl, A. A. L., Faller, K., Groen, E. J. N., Kline, R., Eaton, S., Ledahawsky, L., Chaytow, H., Lamont, D. J., Wishart, T., Huang, Y. & Gillingwater, T., 9 Jul 2020, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  4. Motor neuron translatome reveals deregulation of SYNGR4 and PLEKHB1 in mutant TDP-43 amyotrophic lateral sclerosis models

    Marques, R. F., Engler, J. B., Kuchler, K., Jones, R., Lingner, T., Salinas, G., Gillingwater, T., Friese, M. A. & Duncan, K. E., 7 Jul 2020, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  5. Neural circuit reorganisation after spinal cord injury in Zebrafish

    El-Daher, F. & Becker, C. G., 27 Jun 2020, In : Current Opinions in Genetics and Developments. 64

    Research output: Contribution to journalArticle

  6. Excellent reliability of the ALSFRS-R administered via videoconferencing: A study of people with motor neuron disease in Scotland

    Newton, J., Jayaprakash, K., Glasmacher, S. A., Mceleney, A., Bethell, A., Fraser, E., Hatrick, J., Haagenrud, H., Stott, G., Dakin, R., Chandran, S. & Pal, S., 21 Jun 2020, In : Journal of the Neurological Sciences. 416, p. 116991

    Research output: Contribution to journalArticle

  7. Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines.

    Madole, J. W., Ritchie, S. J., Cox, S., Buchanan, C., Valdes Hernandez, M., Muñoz Maniega, S., Wardlaw, J., Harris, M., Bastin, M., Deary, I. & Tucker-Drob, E. M., 6 Jun 2020, (Accepted/In press) In : Biological Psychiatry.

    Research output: Contribution to journalArticle

  8. Therapeutic Targeting of Proteostasis in Amyotrophic Lateral Sclerosis—a Systematic Review and Meta-Analysis of Preclinical Research

    Elliott, E., Bailey, O., Waldron, F. M., Hardingham, G. E., Chandran, S. & Gregory, J. M., 25 May 2020, In : Frontiers in Neuroscience. 14

    Research output: Contribution to journalArticle

  9. Riluzole prescribing, uptake and treatment discontinuation in people with amyotrophic lateral sclerosis in Scotland

    Jayaprakash, K., Glasmacher, S. A., Pang, B., Beswick, E., Mehta, A. R., Dakin, R., Newton, J., Chandran, S. & Pal, S., 23 May 2020, In : Journal of Neurology.

    Research output: Contribution to journalArticle

  10. Multidimensional apathy in behavioural variant frontotemporal dementia, primary progressive aphasia and Alzheimer’s disease

    Radakovic, R., Colville, S., Starr, J., Pal, S. & Abrahams, S., 15 May 2020, In : Journal of Geriatric Psychiatry and Neurology.

    Research output: Contribution to journalArticle

  11. Evolution of white matter damage in amyotrophic lateral sclerosis

    Gabel, M. C., Broad, R. J., Young, A. L., Abrahams, S., Bastin, M., Menke, R. A. L., Al Chalabi, A., Goldstein, L. H., Tsermentseli, S., Alexander, D. C., Turner, M. R., Leigh, N. & Cercignani, M., 4 May 2020, In : Annals of Clinical and Translational Neurology.

    Research output: Contribution to journalArticle

  12. National audit of cognitive assessment in people with pwMND A national audit of cognitive assessment in people with motor neurone disease (pwMND) in Scotland

    Stavrou, M., Newton, J., Stott, G., Colville, S., Chandran, S., Abrahams, S., Pal, S. & Davenport, R., 20 Apr 2020, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. p. 1-4

    Research output: Contribution to journalArticle

  13. aNMJ-morph – A simple macro for rapid analysis of neuromuscular junction (NMJ) morphology

    Minty, G., Hoppen, A., Boehm, I., Alhindi, A., Gibb, L., Potter, E., Wagner, B., Miller, J., Skipworth, R., Gillingwater, T. & Jones, R., 15 Apr 2020, In : Royal Society Open Science.

    Research output: Contribution to journalArticle

  14. Dynamic cell interactions allow spinal cord regeneration in zebrafish

    Becker, T. & Becker, C. G., 1 Apr 2020, In : Current opinion in physiology.

    Research output: Contribution to journalArticle

  15. Relationship between neuropsychiatric disorders and cognitive and behavioural change in MND

    McHutchison, C. A., Leighton, D. J., McIntosh, A., Cleary, E., Warner, J., Porteous, M., Chandran, S., Pal, S. & Abrahams, S., Mar 2020, In : Journal of Neurology, Neurosurgery & Psychiatry. 91, 3, p. 245-253

    Research output: Contribution to journalArticle

  16. Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

    Khan, A., Paro, S., McGurk, L., Sambrani, N., Hogg, M. C., Brindle, J., Pennetta, G., Keegan, L. P. & O'Connell, M. A., 14 Feb 2020, In : BMC Biology. 18, 1, p. 15

    Research output: Contribution to journalArticle

  17. Reliability and validity of the brief Dimensional Apathy Scale (b-DAS)

    Radakovic, R., Gray, D., Dudley, K., Mioshi, E., Dick, D., Melchiorre, G., Gordon, H., Newton, J., Colville, S., Pal, S. & Abrahams, S., 11 Feb 2020, In : Archives of Clinical Neuropsychology. 6 p.

    Research output: Contribution to journalArticle

  18. Executive, language and fluency dysfunction are markers of localised TDP-43 cerebral pathology in non-demented ALS

    Gregory, J., McDade, K., Bak, T., Pal, S., Chandran, S., Smith, C. & Abrahams, S., Feb 2020, In : Journal of Neurology, Neurosurgery & Psychiatry. 91, 2, p. 149-157

    Research output: Contribution to journalArticle

  19. Spatial transcriptomics identifies spatially dysregulated expression of GRM3 and USP47 in amyotrophic lateral sclerosis

    Gregory, J. M., McDade, K., Livesey, M. R., Croy, I., Marion de Proce, S., Aitman, T., Chandran, S. & Smith, C., 10 Jan 2020, In : Neuropathology and Applied Neurobiology.

    Research output: Contribution to journalArticle

  20. Lentiviral delivery of human erythropoietin attenuates hippocampal atrophy and improves cognition in the R6/2 mouse model of Huntington's disease

    Rolfes, S., Munro, D., Lyras, E-M., Matute, E., Ouk, K., Harms, C., Böttcher, C. & Priller, J., 2020, In : Neurobiology of disease.

    Research output: Contribution to journalArticle

  21. 2019
  22. PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins

    Corbett, G. T., Wang, Z., Hong, W., Colom Cadena, M., Rose, J., Liao, M., Asfaw, A., Hall, T. C., Ding, L., DeSousa, A., Frosch, M. P., Collinge, J., Harris, D. A., Perkington, M. S., Spires-Jones, T., Young-Pearse, T. L., Billington, A. & Walsh, D. M., 18 Dec 2019, In : Acta Neuropathologica.

    Research output: Contribution to journalArticle

  23. Etymology and the neuron(e)

    Mehta, A. R., Mehta, P. R., Anderson, S. P., Mackinnon, B. L. H. & Compston, A., 17 Dec 2019, In : Brain.

    Research output: Contribution to journalArticle

  24. Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology

    Zhao, C., Devlin, A., Chouhan, A. K., Selvaraj, B. T., Stavrou, M., Burr, K., Brivio, V., He, X., Mehta, A. R., Story, D., Shaw, C. E., Dando, O., Hardingham, G. E., Miles, G. B. & Chandran, S., 16 Dec 2019, In : Glia.

    Research output: Contribution to journalArticle

  25. Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

    Kouloulia, S., Hallin, E. I., Simbriger, K., Amorim, I. S., Lach, G., Amvrosiadis, T., Chalkiadaki, K., Kampaite, A., Truong, V. T., Hooshmandi, M., Jafarnejad, S. M., Skehel, P., Kursula, P., Khoutorsky, A. & Gkogkas, C. G., 10 Dec 2019, In : Cell Reports. 29, 11, p. 3620-3635.e7

    Research output: Contribution to journalArticle

  26. Survival and Prognostic Factors in C9orf72 Repeat Expansion Carriers: A Systematic Review and Meta-analysis

    Glasmacher, S. A., Wong, C., Pearson, I. E. & Pal, S., 18 Nov 2019, In : JAMA Neurology.

    Research output: Contribution to journalArticle

  27. Integrated Flexible Hybrid Silicone-Textile Dual-Resonant Sensors and Switching Circuit for Wearable Neurodegeneration Monitoring Systems

    Saied, I., Chandran, S. & Arslan, T., 4 Nov 2019, In : IEEE Transactions on Biomedical Circuits and Systems.

    Research output: Contribution to journalArticle

  28. Interaction of axonal Chondrolectin with Collagen XIXa1 is necessary for precise neuromuscular junction formation

    Oprisoreanu, A., Smith, H., Ayra, S., Webster, R., Zhong, Z., Wehner, D., Cardozo, M. J., Becker, T., Talbot, K. & Becker, C. G., 29 Oct 2019, In : Cell Reports. 29, 5

    Research output: Contribution to journalArticle

  29. Neuropsychological and functional assessment across different cultures and continents

    Bak, T., 15 Oct 2019, In : Journal of the Neurological Sciences. 405, p. 67

    Research output: Contribution to journalShort survey

  30. The clinical impact of the Edinburgh Cognitive and Behavioural ALS Screen (ECAS) and neuropsychological intervention in routine ALS care

    Hodgins, F., Mulhern, S. & Abrahams, S., 15 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.

    Research output: Contribution to journalArticle

  31. A single systemic inflammatory insult causes acute motor deficits and accelerates disease progression in a mouse model of human tauopathy

    Torvell, M., Hampton, D. W., Connick, P., Maclullich, A. M. J., Cunningham, C. & Chandran, S., 9 Oct 2019, In : Alzheimer's and Dementia: Translational Research and Clinical Interventions. 5, p. 579-591

    Research output: Contribution to journalArticle

  32. An epidemiological profile of dysarthria incidence and assistive technology use in the living population of people with MND in Scotland

    Elliott, E., Newton, J., Rewaj, P., Gregory, J. M., Tomarelli, L., Colville, S., Chandran, S. & Pal, S., 9 Oct 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. p. 1-7

    Research output: Contribution to journalArticle

  33. Dysregulation of AMPA receptor subunit expression in sporadic ALS post‐mortem brain

    Gregory, J. M., Livesey, M. R., Mcdade, K., Selvaraj, B. T., Barton, S. K., Chandran, S. & Smith, C., 3 Oct 2019, In : The Journal of Pathology.

    Research output: Contribution to journalArticle

  34. Altered mitochondrial bioenergetics are responsible for the delay in Wallerian degeneration observed in neonatal mice.

    Kline, R., Dissanayake, K., Llavero hurtado, M. D. C., Martínez, N. W., Ahl, A., Mole, A. J., Lamont, D. J., Court, F. A., Ribchester, R., Wishart, T. & Murray, L., Oct 2019, In : Neurobiology of disease. 130, 104496.

    Research output: Contribution to journalArticle

  35. Extending a Hodgkin-Huxley Model for Larval Drosophila Muscle Excitability via Particle Swarm Fitting

    Piho, P., Margetiny, F., Bartocci, E., Ribchester, R. & Hillston, J., 17 Sep 2019, Computational Methods in Systems Biology: CMSB 2019. Bortolussi, L. & Sanguinetti, G. (eds.). Springer, Cham, p. 120-139 20 p. (Lecture Notes in Computer Science; vol. 11773).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. NMDA receptor C-terminal signaling in development, plasticity, and disease

    Hardingham, G., 30 Aug 2019, In : F1000Research. 8

    Research output: Contribution to journalReview article

  37. The Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS): Sensitivity in differentiating between ALS and Alzheimer's disease in a Greek population

    Kourtesis, P., Christidi, F., Margioti, E., Demenega, C., Michail, R., Evdokimidis, I. & Abrahams, S., 30 Aug 2019, In : Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration.

    Research output: Contribution to journalArticle

  38. Neuronal clusterin expression is associated with cognitive protection in amyotrophic lateral sclerosis

    Gregory, J. M., Elliot, E., Mcdade, K., Bak, T., Pal, S., Chandran, S., Abrahams, S. & Smith, C., 28 Aug 2019, In : Neuropathology and Applied Neurobiology.

    Research output: Contribution to journalArticle

  39. Abnormal fatty acid metabolism is a core component of spinal muscular atrophy

    Deguise, M-O., Baranello, G., Mastella, C., Beauvais, A., Michaud, J., Leone, A., De Amicis, R., Battezzati, A., Dunham, C., Selby, K., Warman Chardon, J., McMillan, H. J., Huang, Y-T., Courtney, N. L., Mole, A. J., Kubinski, S., Claus, P., Murray, L. M., Bowerman, M., Gillingwater, T. H. & 3 others, Bertoli, S., Parson, S. H. & Kothary, R., 11 Aug 2019, In : Annals of Clinical and Translational Neurology. 6, 8, p. 1519-1532 14 p.

    Research output: Contribution to journalArticle

  40. Lamin A/C dysregulation contributes to cardiac pathology in a mouse model of severe spinal muscular atrophy

    Šoltić, D., Shorrock, H. K., Allardyce, H., Wilson, E. L., Holt, I., Synowsky, S. A., Shirran, S. L., Parson, S. H., Gillingwater, T. H. & Fuller, H. R., 9 Aug 2019, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  41. Recommendations for the non-pharmacological treatment of apathy in brain disorders

    Manera, V., Abrahams, S., Agüera-Ortiz, L., Bremond, F., Renaud, D., Fairchild, K., Hanon, A., Husain, M., König, A., Lockwood, P., Maribel, P., Radakovic, R., Robert, G., Slachevsky, A., Stella, F., Tribouillard, A., Trimarchi, P. D., Verhey, F. R. J., Yesavage, J., Zeghari, R. & 1 others, Robert, P., 9 Aug 2019, In : American Journal of Geriatric Psychiatry. 28, 4, p. 410-420

    Research output: Contribution to journalArticle

  42. AAV9-Stathmin1 gene delivery improves disease phenotype in an intermediate mouse model of Spinal Muscular Atrophy

    Villalon, E., Kline, R. A., Smith, C. E., Lorson, Z. C., Osman, E. Y., O'Day, S., Murray, L. & Lorson, C. L., 31 Jul 2019, In : Human Molecular Genetics.

    Research output: Contribution to journalArticle

  43. Nox2 contributes to age-related oxidative damage to neurons and the cerebral vasculature

    Fan, L. M., Geng, L., Cahill-smith, S., Liu, F., Douglas, G., Mckenzie, C., Smith, C., Brooks, G., Channon, K. M. & Li, J., 22 Jul 2019, In : Journal of Clinical Investigation.

    Research output: Contribution to journalArticle

  44. Central nervous system regeneration is driven by microglia necroptosis and repopulation

    Lloyd, A. F., Davies, C. L., Holloway, R. K., Labrak, Y., Ireland, G., Carradori, D., Dillenburg, A., Borger, E., Soong, D., Richardson, J. C., Kuhlmann, T., Williams, A., Pollard, J. W., des Rieux, A., Priller, J. & Miron, V. E., 10 Jun 2019, In : Nature Neuroscience.

    Research output: Contribution to journalArticle

  45. The brief dimensional apathy scale (b-DAS): A short clinical assessment of apathy

    Radakovic, R., McGrory, S., Chandran, S., Swingler, R., Pal, S., Stephenson, L., Colville, S., Newton, J., Starr, J. & Abrahams, S., 3 Jun 2019, In : Clinical Neuropsychologist.

    Research output: Contribution to journalArticle

  46. Could an Impairment in Local Translation of mRNAs in Glia be Contributing to Pathogenesis in ALS?

    Barton, S. K., Gregory, J. M., Chandran, S. & Turner, B. J., 21 May 2019, In : Frontiers in Molecular Neuroscience. 12

    Research output: Contribution to journalArticle

  47. Hierarchical Complexity of the Adult Human Structural Connectome

    Smith, K., Bastin, M., Cox, S., Valdes Hernandez, M., Wiseman, S., Escudero, J. & Sudlow, C., May 2019, In : NeuroImage. 191, p. 205-215

    Research output: Contribution to journalArticle

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