Edinburgh Research Explorer

Hepatology/Gastroenterology

Organisational unit: Research Group

  1. 2020
  2. Development of a cost effective automated platform to produce human liver spheroids for basic and applied research

    Lucendo-Villarin, B., Meseguer Ripolles, J., Drew, J., Fisher, L., Ma, E., Flint, O., Simpson, K. J., Machesky, L. M., Mountford, J. C. & Hay, D. C., 28 Oct 2020, In: Biofabrication.

    Research output: Contribution to journalArticlepeer-review

  3. The eye as a non-invasive window to the microcirculation in liver cirrhosis: a prospective pilot study

    Gifford, F., Moroni, F., Farrah, T., Hetherington, K., MacGillivray, T., Hayes, P. C., Dhaun, N. & Fallowfield, J. A., 17 Oct 2020, In: Journal of Clinical Medicine.

    Research output: Contribution to journalArticlepeer-review

  4. Genome-wide association study for alcohol-related cirrhosis Identifies risk loci in MARC1 and HNRNPUL1

    Innes, H. A., Buch, S., Hutchinson, S. J., Neil Guha, I., Morling, J. R., Barnes, E., Irving, W., Forrest, E., Pedergnana, V., Goldberg, D. J., Aspinall, E. J., Barclay, S., Hayes, P. C., Dillon, J., Dieter Nischalke, H., Lutz, P., Spengler, U., Fischer, J., Berg, T., Brosch, M. & 11 others, Eyer, F., Data, C., Mueller, S., Peccerella, T., Deltenre, P., Merot, A., Soyka, M., McQuillin, A., Morgan, M. Y., Hampe, J. & Stickel, F., 5 Oct 2020.

    Research output: Contribution to conferencePaperpeer-review

  5. Guidelines on the management of ascites in cirrhosis

    Aithal, G. P., Palaniyappan, N., China, L., Harmala, S., Macken, L., Ryan, J., A Wilkes, E., Moore, K., Leithead, J. A., Hayes, P. C., O'Brien, A. J. & Verma, S., 4 Sep 2020.

    Research output: Contribution to conferencePaperpeer-review

  6. Ribavirin for Hepatitis E Virus Infection After Organ Transplantation: A Large European Retrospective Multicenter Study

    Hepatitis E Virus Ribavirin Study Group & Simpson, K. J., 1 Sep 2020, In: Clinical Infectious Diseases. 71, 5, p. 1204-1211 8 p.

    Research output: Contribution to journalArticlepeer-review

  7. Expression Profiles of Exosomal MicroRNAs from HEV- and HCV-Infected Blood Donors and Patients: A Pilot Study

    McGowan, K., Simpson, K. J. & Petrik, J., 30 Jul 2020, In: Viruses. 12, 8

    Research output: Contribution to journalArticlepeer-review

  8. aMAP risk score predicts hepatocellular carcinoma development in patients with chronic hepatitis

    Fan, R., Papatheodoridis, G., Sun, J., Innes, H., Toyoda, H., Xie, Q., Mo, S., Sypsa, V., Guha, I. N., Kumada, T., Niu, J., Dalekos, G., Yasuda, S., Barnes, E., Lian, J., Suri, V., Idilman, R., Barclay, S. T., Dou, X., Berg, T. & 22 others, Hayes, P. C., Flaherty, J. F., Zhou, Y., Zhang, Z., Buti, M., Hutchinson, S. J., Guo, Y., Calleja, J. L., Lin, L., Zhao, L., Chen, Y., Janssen, H. L. A., Zhu, C., Shi, L., Tang, X., Gaggar, A., Wei, L., Jia, J., Irving, W. L., Johnson, P. J., Lampertico, P. & Hou, J., 20 Jul 2020, In: Journal of Hepatology.

    Research output: Contribution to journalArticlepeer-review

  9. Non-invasive risk scores do not reliably identify future cirrhosis or hepatocellular carcinoma in Type 2 diabetes: The Edinburgh Type 2 Diabetes Study

    Grecian, S., McLachlan, S., Fallowfield, J. A., Kearns, P., Hayes, P. C., Guha, I. N., Morling, J., Glancy, S., Williamson, R. M., Reynolds, R. M., Frier, B., Zammitt, N. N., Price, J. F. & Strachan, M., 7 Jul 2020, In: Liver International.

    Research output: Contribution to journalArticlepeer-review

  10. Randomised clinical trial: standard of care versus early-transjugular intrahepatic porto-systemic shunt (TIPSS) in patients with cirrhosis and oesophageal variceal bleeding

    Dunne, P., Sinha, R., Stanley, A. J., Lachlan, N., Ireland, H., Shams, A., Kasthuri, R., Forrest, E. H. & Hayes, P., Jul 2020, In: Alimentary Pharmacology and Therapeutics. 52, 1, p. 98

    Research output: Contribution to journalArticlepeer-review

  11. A Volatomic Analysis Identifies Compounds for Stratification of Non- Alcoholic Fatty Liver Disease: A Pilot Study

    Sinha, R., Lockman, K. A., Homer, N., Bower, E., Brinkman, P., Knobel, H., Fallowfield, J., Jaap, A., Hayes, P. & Plevris, J., 15 Jun 2020, In: JHEP Reports.

    Research output: Contribution to journalArticlepeer-review

  12. Volatomic analysis identifies compounds that can stratify non-alcoholic fatty liver disease

    Sinha, R., Lockman, K. A., Homer, N., Bower, E., Brinkman, P., Knobel, H. H., Fallowfield, J., Jaap, A. J., Hayes, P. & Plevris, J. N., 15 Jun 2020, In: JHEP Reports.

    Research output: Contribution to journalArticlepeer-review

  13. When Is a Critically Ill Cirrhotic Patient Too Sick to Transplant? Development of Consensus Criteria by a Multidisciplinary Panel of 35 International Experts

    Weiss, E., Saner, F., Asrani, S. K., Biancofiore, G., Blasi, A., Lerut, J., Durand, F., Fernandez, J., Findlay, J. Y., Fondevila, C., Francoz, C., Gustot, T., Jaber, S., Karvellas, C., Kronish, K., Laleman, W., Laterre, P. F., Levesque, E., Mandell, S. M., McPhail, M. & 16 others, Muiesan, P., Olson, J. C., Olthoff, K., Pinna, A. D., Reiberger, T., Reyntjens, K., Saliba, F., Scatton, O., Simpson, K. J., Soubrane, O., Subramanian, R. M., Tacke, F., Tomescu, D., Xia, V., Wagener, G. & Paugam-Burtz, C., 15 Jun 2020, In: Transplantation.

    Research output: Contribution to journalArticlepeer-review

  14. SARS-CoV-2 and the liver

    Morgan, K., Samuel, K., Vandeputte, M., Hayes, P. & Plevris, J., 30 May 2020, In: Pathogens. 9, 6, 430.

    Research output: Contribution to journalReview articlepeer-review

  15. The reported ‘clear cut time association between interferon-free treatment and HCC’ is anything but clear cut

    Innes, H. A., Mcdonald, S. A., Barclay, S. T., Irving, W. L., Hayes, P. C. & Hutchinson, S. J., 1 May 2020, In: Journal of Hepatology. 72, 5, p. 1034-1035

    Research output: Contribution to journalLetter

  16. Mortality and morbidity of locally acquired hepatitis E in the national Scottish cohort: a multicentre retrospective study

    Wallace, S. J., Swann, R., Donnelly, M., Kemp, L., Guaci, J., Murray, A., Spoor, J., Lin, N., Miller, M., Dalton, H. R., Hussaini, S. H., Gunson, R., Simpson, K., Stanley, A. & Fraser, A., May 2020, In: Alimentary Pharmacology and Therapeutics. 51, 10, p. 974-986 13 p.

    Research output: Contribution to journalArticlepeer-review

  17. Oxygen plasma substrate and specific nanopattern promote early differentiation of HepaRG progenitors

    Morgan, K., Bryans, A., Brzeszczyński, F., Samuel, K., Treskes, P., Brzeszczynska, J., Morley, S. D., Hayes, P. C., Gadegaard, N., Nelson, L. J. & Plevris, J. N., 15 Apr 2020, In: Tissue Engineering, Part A.

    Research output: Contribution to journalArticlepeer-review

  18. Population impact of direct-acting antiviral treatment on new presentations of hepatitis C-related decompensated cirrhosis: a national record-linkage study

    Hutchinson, S. J., Valerio, H., McDonald, S. A., Yeung, A., Pollock, K., Smith, S., Barclay, S., Dillon, J. F., Fox, R., Bramley, P., Fraser, A., Kennedy, N., Gunson, R. N., Templeton, K., Innes, H., McLeod, A., Weir, A., Hayes, P. C. & Goldberg, D., 26 Mar 2020, In: Gut.

    Research output: Contribution to journalArticlepeer-review

  19. Validation of Reference Genes for Gene Expression Studies by RT-qPCR in HepaRG Cells during Toxicity Testing and Disease Modelling

    Brzeszczyńska, J., Brzeszczyński, F., Samuel, K., Morgan, K., Morley, S. D., Plevris, J. N. & Hayes, P. C., 21 Mar 2020, In: Cells. 9, 3

    Research output: Contribution to journalArticlepeer-review

  20. A Phase 2 Randomised Controlled Trial of Serelaxin to Lower Portal Pressure in Cirrhosis (STOPP)

    Gifford, F., Dunne, P., Weir, G., Graham, C., Tuck, S., Hayes, P. & Fallowfield, J., 12 Mar 2020, In: Trials.

    Research output: Contribution to journalArticlepeer-review

  21. Real-world impact following initiation of interferon-free hepatitis C regimens on liver-related outcomes and all-cause mortality among patients with compensated cirrhosis

    McDonald, S. A., Pollock, K. G. J., Barclay, S. T., Goldberg, D. J., Bathgate, A. J., Bramley, P., Dillon, J., Fraser, A., Innes, H., Kennedy, N., Morris, J., Went, A., Hayes, P. & Hutchison, S., Mar 2020, In: Journal of Viral Hepatitis.

    Research output: Contribution to journalArticlepeer-review

  22. Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension

    Tripathi, D., Stanley, A. J., Hayes, P. C., Travis, S., Armstrong, M. J., Tsochatzis, E. A., Rowe, I. A., Roslund, N., Ireland, H., Lomax, M., Leithead, J. A., Mehrzad, H., Aspinall, R. J., McDonagh, J. & Patch, D., 29 Feb 2020

    Research output: Other contribution

  23. Role of impedance based cellular assays in Hepatology research

    Morgan, K., Gamal, W., Samuel, K., Morley, S., Hayes, P., Bagnaninchi, P. & Plevris, J., 15 Jan 2020, Encyclopedia. MDPI AG

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  24. Transjugular intrahepatic portosystemic stent-shut in the management of portal hypertension

    Tripathi, D., Stanley, A. J., Hayes, P., Travis, S. P. L., Armstrong, M., Tsochatzis, E., Rowe, I., Roslund, N., Ireland, H., Lomax, M., Leithead, J., Mehrzad, H., Aspinall, R., McDonagh, J. & Patch, D., Jan 2020.

    Research output: Contribution to conferencePaperpeer-review

  25. 2019
  26. Application of Impedance-Based Techniques in Hepatology Research

    Morgan, K., Gamal, W., Samuel, K., Morley, S. D., Hayes, P. C., Bagnaninchi, P. & Plevris, J. N., 24 Dec 2019, In: Journal of Clinical Medicine. 9, 1, p. 50

    Research output: Contribution to journalArticlepeer-review

  27. Coffee consumption and kidney function: A Mendelian randomisation study

    Kennedy, O. J., Pirastu, N., Poole, R., Fallowfield, J., Hayes, P., Grzeszkowiak, E. J., Taal, M. W., Wilson, J., Parkes, J. & Roderick, P., 11 Dec 2019, In: American Journal of Kidney Diseases.

    Research output: Contribution to journalArticlepeer-review

  28. Using problem-based learning (PBL) to engage undergraduate medical students in endocrinology at Edinburgh Medical School

    Pender, F. T. & Morley, S. D., 11 Nov 2019, In: Endocrine Abstracts. 65, 1 p., P248.

    Research output: Contribution to journalMeeting abstractpeer-review

  29. Safety profile of autologous macrophage therapy for liver cirrhosis

    Moroni, F., Dwyer, B., Graham, C., Pass, C., Bailey, L., Ritchie, L., Mitchell, D., Glover, A., Laurie, A., Doig, S., Hargreaves, E., Fraser, A. R., Turner, M. L., Campbell, J. D. M., McGowan, N. W. A., Barry, J., Moore, J. K., Hayes, P. C., Leeming, D. J., Nielsen, M. J. & 3 others, Musa, K., Fallowfield, J. A. & Forbes, S. J., Oct 2019, In: Nature Medicine. 25, 10, p. 1560–1565 6 p.

    Research output: Contribution to journalArticlepeer-review

  30. THE EYE AS A NON-INVASIVE WINDOW TO THE MICROCIRCULATION IN CIRRHOSIS: A PROSPECTIVE COHORT STUDY

    Gifford, F. J., Moroni, F., Farrah, T., Hetherington, K., MacGillivray, T. J., Hayes, P., Dhaun, N. & Fallowfield, J. A., Oct 2019, In: Hepatology. 70, p. 193A-193A 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  31. Baseline neutrophil-to-lymphocyte ratio predicts response to corticosteroids and is associated with infection and renal dysfunction in alcoholic hepatitis.

    Forrest, E. H., Storey, N., Sinha, R., Atkinson, S. R., Vergis, N., Richardson, P., Masson, S., Ryder, S., Thursz, M. R., Allison, M., Fraser, A., Austin, A., McCune, A., Dhanda, A., Katarey, D., Potts, J., Verma, S., Parker, R. & Hayes, P., Aug 2019, In: Alimentary Pharmacology and Therapeutics. 50, 4

    Research output: Contribution to journalArticlepeer-review

  32. Uptake of endoscopic screening for gastroesophageal varices and factors associated with variceal bleeding in patients with chronic hepatitis C infection and compensated cirrhosis, 2005-2016: a national database linkage study.

    McDonald, S. A., Barclay, S. T., Hutchinson, S. J., Stanley, A. J., Fraser, A., Dillon, J. F., Innes, H. A., Peters, E., Kennedy, N., Bathgate, A. J., Bramley, P., Morris, J., Goldberg, D. J. & Hayes, P., Aug 2019, In: Alimentary Pharmacology and Therapeutics. 50, 4

    Research output: Contribution to journalArticlepeer-review

  33. Gut-liver crosstalk and gut homeostasis in paracetamol toxicity: In Vitro Study Using Impedence-Based Assay

    Morgan, K., Samuel, K., Gamal, W., Morley, S., Hayes, P., Bagnaninchi, P. & Plevris, J., Jun 2019, In: Gut. 68, Suppl 2: A1–A269, p. A124 1 p., PTU-026.

    Research output: Contribution to journalMeeting abstractpeer-review

  34. Experiences of diagnosis, stigma, culpability and disclosure in male patients with hepatitis C virus: An interpretative phenomenological analysis.

    Krzeczkowska, A., Flowers, P., Chouliara, Z., Hayes, P. & Dickson, A., 13 May 2019, In: Health.

    Research output: Contribution to journalArticlepeer-review

  35. Study protocol for a randomised controlled trial of carvedilol versus variceal band ligation in primary prevention of variceal bleeding in liver cirrhosis

    CALIBRE trial collaborative group, 25 Apr 2019, In: BMJ open gastroenterology.

    Research output: Contribution to journalArticlepeer-review

  36. Chlorpromazine toxicity is associated with disruption of cell membrane integrity and initiation of a pro-inflammatory response in the HepaRG hepatic cell line

    Morgan, F., Martucci, N., Kozlowska, A., Gamal, W., Brzeszczynki, F., Treskes, P., Samuel, K., Hayes, P., Nelson, L., Bagnaninchi, P., Brzeszczynska, J. & Plevris, J., Mar 2019, In: Biomedicine and Pharmacotherapy. 111, p. 1408-1416 9 p.

    Research output: Contribution to journalArticlepeer-review

  37. Loss of integrin αvβ8 in murine hepatocytes accelerates liver regeneration

    Greenhalgh, S., Matchett, K., Taylor, R., Huang, K., Li, J. T., Saeteurn, K., Donnelly, M. C., Simpson, E. E. M., Pollack, J. L., Atakilit, A., Simpson, K., Maher, J. J., Iredale, J., Sheppard, D. & Henderson, N., 1 Feb 2019, In: American Journal of Pathology. 189, 2, p. 258-271

    Research output: Contribution to journalArticlepeer-review

  38. 2018
  39. QRT-PCR analysis of the effect of in utero exposure to sewage sludge on steroidogenic gene expression in ovine fetal adrenal gland

    Cooper, E. A., Reddy, S., Allenson, A. Z., Cooper, D. P., Fowler, P. A., T Rae, M. T. & Morley, S. D., Nov 2018, In: Endocrine Abstracts. 59, p. P038 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  40. Letter to the Editor: Human based systems: Mechanistic NASH modelling just around the corner?'

    Morgan, F., Fassoula, V., Samuel, K., Morley, S., Hayes, P. & Plevris, J., 10 Oct 2018, In: Pharmacological Research. 137, p. 208-281 2 p., https://doi.org/10.1016/j.phrs.2018.09.028.

    Research output: Contribution to journalLetterpeer-review

  41. Earlier use of capsule endoscopy in inpatients with melena or severe iron deficiency anemia reduces need for colonoscopy and shortens hospital stay

    Yung, D. E., Koulaouzidis, A., Douglas, S. & Plevris, J. N., Sep 2018, In: Endoscopy International Open. 6, 9, p. E1075-E1084

    Research output: Contribution to journalArticlepeer-review

  42. 'It's been a long haul, a big haul, but we've made it': hepatitis C virus treatment in post-transplant patients with virus recurrence: An interpretative phenomenological analysis.

    Krzeczkowska, A., Flowers, P., Chouliara, Z., Hayes, P. & Dickson, A., 6 Aug 2018, In: Health Psychology Open.

    Research output: Contribution to journalArticlepeer-review

  43. Index serum hyaluronic acid independently and accurately predicts mortality in patients with liver disease

    Plevris, N., Sinha, R., Hay, A. W., McDonald, N., Plevris, J. N. & Hayes, P. C., Aug 2018, In: Alimentary Pharmacology and Therapeutics.

    Research output: Contribution to journalArticlepeer-review

  44. Computer simulation of neutral drift among limbal epithelial stem cells of mosaic mice

    West, J. D., Mort, R. L., Hill, R. E., Morley, S. D. & Collinson, J. M., 1 Jul 2018, In: Stem cell research. 30, p. 1-11

    Research output: Contribution to journalArticlepeer-review

  45. A study of breath metabolome in Non-alcoholic fatty liver disease

    Sinha, R., Lockman, K. A., Homer, N., Bower, E., Brinkman, P., Knobel, H., Chamuleau, R., Jaap, A., Hayes, P. & Plevris, J., Apr 2018, In: Journal of Hepatology. 68, p. S557-S558 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  46. Electronic-nose breath print distinguishes non-alcoholic fatty liver disease from healthy lean control: A pilot study

    Sinha, R., Gallagher, I., Lockman, K. A., Chamuleau, R., Jaap, A., Hayes, P. & Plevris, J., Apr 2018, In: Journal of Hepatology. 68, p. S556-S557 2 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  47. Challenges in the diagnosis of leptospirosis outwith endemic settings: a Scottish single centre experience

    Russell, C. D., Jones, M. E., O'Shea, D. T., Simpson, K. J., Mitchell, A. & Laurenson, I. F., 31 Mar 2018, In: Journal of the Royal College of Physicians of Edinburgh. 48, 1, p. 9-15 7 p.

    Research output: Contribution to journalArticlepeer-review

  48. Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? A population-level analysis

    Wang, H., Swann, R., Thomas, E., Innes, H. A., Valerio, H., Hayes, P. C., Allen, S., Barclay, S. T., Wilks, D., Fox, R., Bhattacharyya, D., Kennedy, N., Morris, J., Fraser, A., Stanley, A. J., Gunson, R., Mclntyre, P. G., Hunt, A., Hutchinson, S. J., Mills, P. R. & 1 others, Dillon, J. F., 25 Mar 2018, In: Journal of Viral Hepatitis.

    Research output: Contribution to journalArticlepeer-review

  49. Hepatitis E virus (HEV) in Scotland: evidence of recent increase in viral circulation in humans

    Thom, K., Gilhooly, P., McGowan, K., Malloy, K., Jarvis, L. M., Crossan, C., Scobie, L., Blatchford, O., Smith-Palmer, A., Donnelly, M. C., Davidson, J. S., Johannessen, I., Simpson, K. J., Dalton, H. R. & Petrik, J., 22 Mar 2018, In: Eurosurveillance. 23, 12

    Research output: Contribution to journalArticlepeer-review

  50. Palliative care for people with advanced liver disease: a feasibility trial of a supportive care liver nurse specialist

    Kimbell, B., Murray, S., Byrne, H., Baird, A., Hayes, P. C., MacGilchrist, A., Finucane, A., Brookes-Young, P., O'Carroll, R., Weir, C. J., Kendall, M. & Boyd, K., 8 Mar 2018, In: Palliative Medicine. p. 1-11

    Research output: Contribution to journalArticlepeer-review

  51. Endoscopic ultrasound assessment of gastrointestinal polypoid lesions of indeterminate morphology in patients with portal hypertension

    Sigounas, D. E., Shams, A., Hayes, P. C. & Plevris, J. N., Mar 2018, In: Endoscopy International Open. 6, 3, p. E292-E299

    Research output: Contribution to journalArticlepeer-review

  52. Nondestructive Optical Toxicity Assays of 3D Liver Spheroids with Optical Coherence Tomography

    Martucci, N. J., Morgan, K., Anderson, G. W., Hayes, P. C., Plevris, J. N., Nelson, L. J. & Bagnaninchi, P. O., Mar 2018, In: Advanced Biosystems. 2, 3, p. 1700212

    Research output: Contribution to journalArticlepeer-review

  53. Primary prophylaxis of variceal bleeding.

    Robertson, M. & Hayes, P., 2 Feb 2018, In: Hepatology International.

    Research output: Contribution to journalEditorialpeer-review

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