Edinburgh Research Explorer

Small Vessel Disease Research

Organisational unit: Research Group

  1. 'Small vessels, dementia and chronic diseases -molecular mechanisms and pathophysiology' Workshop proceedings

    Horsburgh, K., Wardlaw, J., Van Agtmael, T., Allan, S., Ashford, M., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davies, J. B., Duncombe, J., Farr, T. D., Fowler, J., Goense, J., Granata, A., Hall, C., Hainsworth, A., Harvey, A., Hawkes, C. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., MacLeod, M., Macrae, M., Markus, H. S., McCabe, C., McColl, B., Meakin, P. J., Miller, A. A., Nedergaard, M., O'Sullivan, M., Quinn, T., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R., Trueman, R., Wang, T., Williams, A., Williams, S. & Work, L. M., 30 Apr 2018, In: Clinical science. 132, 8, p. 851-868

    Research output: Contribution to journalReview articlepeer-review

  2. 'Where are we now with intravenous thrombolysis for acute ischaemic stroke'?

    Sandercock, P., Wardlaw, J. & Lindley, R., Oct 2010, In: International Journal of Stroke. 5, 5, p. 381-382 2 p.

    Research output: Contribution to journalEditorialpeer-review

  3. 11β-hydroxysteroid dehydrogenase type 1, brain atrophy and cognitive decline

    MacLullich, A. M. J., Ferguson, K. J., Reid, L. M., Deary, I. J., Starr, J., Wardlaw, J. M., Walker, B. R., Andrew, R. & Seckl, J. R., Jan 2012, In: Neurobiology of Aging. 33, 1, p. 207.e1–207.e8 8 p.

    Research output: Contribution to journalArticlepeer-review

  4. 17q25 Locus is associated with white matter hyperintensity volume in ischemic stroke, but not with lacunar stroke status

    Adib-Samii, P., Rost, N., Traylor, M., Devan, W., Biffi, A., Lanfranconi, S., Fitzpatrick, K., Bevan, S., Kanakis, A., Valant, V., Gschwendtner, A., Malik, R., Richie, A., Gamble, D., Segal, H., Parati, E. A., Ciusani, E., Holliday, E. G., Maguire, J., Wardlaw, J. & 25 others, Worrall, B., Bis, J., Wiggins, K. L., Longstreth, W., Kittner, S. J., Cheng, Y-C., Mosley, T., Falcone, G. J., Furie, K. L., Leiva-Salinas, C., Lau, B. C., Saleem Khan, M., Sharma, P., Fornage, M., Mitchell, B. D., Psaty, B. M., Sudlow, C., Levi, C., Boncoraglio, G. B., Rothwell, P. M., Meschia, J., Dichgans, M., Rosand, J., Markus, H. S. & Australian Stroke Genetics Collaborative, Jun 2013, In: Stroke; a journal of cerebral circulation. 44, 6, p. 1609-15 7 p.

    Research output: Contribution to journalArticlepeer-review

  5. 21st Annual Conference on Medical Image Understanding and Analysis, MIUA 2017

    Valdes Hernandez, M. (ed.) & Gonzalez-Castro, V. (ed.), 2017, Medical Image Understanding and Analysis - 21st Annual Conference, MIUA 2017, Proceedings. Springer-Verlag, Vol. 723. p. 1-949 949 p. (Communications in Computer and Information Science; vol. 723).

    Research output: Chapter in Book/Report/Conference proceedingOther chapter contribution

  6. 3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

    Kim, J., Valdes Hernandez, M., Royle, N., Muñoz Maniega, S., Aribisala, B., Gow, A., Bastin, M., Deary, I., Wardlaw, J. & Park, J., Jun 2016, In: Computer methods and programs in biomedicine. 129, p. 51-62

    Research output: Contribution to journalArticlepeer-review

  7. 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review

    Morgan, A. G., Thrippleton, M. J., Wardlaw, J. M. & Marshall, I., 16 Sep 2020, In: Journal of Cerebral Blood Flow and Metabolism. p. 0271678X2095201

    Research output: Contribution to journalArticlepeer-review

  8. A Color and Texture Based Hierarchical K-NN Approach to the Classification of Non-melanoma Skin Lesions

    Ballerini, L., Fisher, R. B., Aldridge, B. & Rees, J., 2013, Color Medical Image Analysis. Celebi, M. E. & Schaefer, G. (eds.). Springer Netherlands, p. 63-86 24 p. (Lecture Notes in Computational Vision and Biomechanics; vol. 6).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  9. A Framework for Jointly Assessing and Reducing Imaging Artefacts Automatically Using Texture Analysis and Total Variation Optimisation for Improving Perivascular Spaces Quantification in Brain Magnetic Resonance Imaging

    Bernal, J., Valdés-hernández, M., Ballerini, L., Escudero, J., Jochems, A. C. C., Clancy, U., Doubal, F. N., Stringer, M. S., Thrippleton, M. J., Touyz, R. M. & Wardlaw, J. M., 8 Jul 2020, Conference on Medical Image Understanding and Analysis (MIUA) 2020. Springer, Vol. 1248. p. 171-183 Chapter 14. (Medical Image Understanding and Analysis; vol. 1248).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  10. A General Factor of Brain White Matter Integrity Predicts Information Processing Speed in Healthy Older People

    Penke, L., Maniega, S. M., Murray, C., Gow, A. J., Valdes Hernandez, M., Clayden, J. D., Starr, J., Wardlaw, J. M., Bastin, M. E. & Deary, I. J., 2 Jun 2010, In: The Journal of Neuroscience. 30, 22, p. 7569-7574

    Research output: Contribution to journalArticlepeer-review

  11. A Large Web-Based Observer Reliability Study of Early Ischaemic Signs on Computed Tomography. The Acute Cerebral CT Evaluation of Stroke Study (ACCESS)

    Wardlaw, J. M., von Kummer, R., Farrall, A., Chappell, F. M., Hill, M. & Perry, D., 30 Dec 2010, In: PLoS ONE. 5, 12, p. - 8 p., e15757.

    Research output: Contribution to journalArticlepeer-review

  12. A Parallel Deconvolution Algorithm in Perfusion Imaging

    Zhu, F., Gonzalez, D. R., Carpenter, T., Atkinson, M. & Wardlaw, J., 1 Jul 2011, Healthcare Informatics, Imaging and Systems Biology (HISB), 2011 First IEEE International Conference on. p. 278-283 6 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. A Query-by-Example Content-Based Image Retrieval System of Non-melanoma Skin Lesions

    Ballerini, L., Li, X., Fisher, R. B. & Rees, J., 2010, MEDICAL CONTENT-BASED RETRIEVAL FOR CLINICAL DECISION SUPPORT. Caputo, B., Muller, H., SyedaMahmood, T., Duncan, JS., Wang, F. & KalpathyCramer, J. (eds.). BERLIN: Springer-Verlag GmbH, p. 31-38 8 p.

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  14. A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

    Stringer, M. S., Lee, H., Huuskonen, M. T., MacIntosh, B. J., Brown, R., Montagne, A., Atwi, S., Ramirez, J., Jansen, M. A., Marshall, I., Black, S. E., Zlokovic, B. V., Benveniste, H. & Wardlaw, J. M., Feb 2021, In: Translational Stroke Research. 12, 1, p. 15-30 16 p.

    Research output: Contribution to journalReview articlepeer-review

  15. A Robust Matlab Tool for Gyral Measurements

    Mikhael, S., Gray, C. D., MacGillivray, T. J., Valdés Hernández, M., Hoogendoorn, C. & Pernet, C., 2017, Organization for Human Brain Mapping (OHBM) Annual Meeting. Vancouver

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  16. A Standalone and Robust Matlab Tool for Gyral Measurements

    Mikhael, S., Gray, C. D., MacGillivray, T. J., Valdés Hernández, M., Hoogendoorn, C. & Pernet, C., 2017, SINAPSE Annual Scientific Meeting. Glasgow

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  17. A Systematic Review of Dynamic Cerebral and Peripheral Endothelial Function in Lacunar Stroke Versus Controls

    Stevenson, S. F., Doubal, F. N., Shuler, K. & Wardlaw, J. M., Jun 2010, In: Stroke. 41, 6, p. E434-E442 9 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  18. A Tool For Gyral Ground Truth Measurements

    Mikhael, S., Gray, C., MacGillivray, T., Murray, A., Hoogendoorn, C., Valdes Hernandez, M., Wardlaw, J. & Pernet, C., 2016.

    Research output: Contribution to conferencePaperpeer-review

  19. A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

    Job, D., Dickie, D. A., Rodriguez Gonzalez, D., Robson, A., Danso, S., Pernet, C., Bastin, M., Boardman, J. P., Murray, A. D., Ahearn, T. S., Waiter, G. D., Staff, R. T., Deary, I., Shenkin, S. D. & Wardlaw, J., 18 Jan 2016, In: NeuroImage.

    Research output: Contribution to journalArticlepeer-review

  20. A comparison of location of acute symptomatic versus 'silent' small vessel lesions

    Valdes Hernandez, M., Maconick, L. C., Munoz-Maniega, S., Wang, X., Wiseman, S., Armitage, P., Doubal, F., Makin, S., Sudlow, C., Dennis, M., Deary, I., Bastin, M. & Wardlaw, J., 2015, In: International Journal of Stroke. 10, p. 1044–1050

    Research output: Contribution to journalArticlepeer-review

  21. A diffusion tensor MRI study of white matter integrity in subjects at high genetic risk of schizophrenia

    Munoz Maniega, S., Lymer, G. K., Bastin, M. E., Marjoram, D., Job, D. E., Moorhead, T. W., Owens, D. G., Johnstone, E. C., McIntosh, A. M. & Lawrie, S. M., Dec 2008, In: Schizophrenia Research. 106, 2-3, p. 132-139 8 p.

    Research output: Contribution to journalArticlepeer-review

  22. A four-dimensional computational model of dynamic contrast-enhanced magnetic resonance imaging measurement of subtle blood-brain barrier leakage

    Bernal, J., Valdés-hernández, M. D. C., Escudero, J., Heye, A. K., Sakka, E., Armitage, P. A., Makin, S., Touyz, R. M., Wardlaw, J. M. & Thrippleton, M. J., 23 Jan 2021, In: NeuroImage. 230, p. 117786

    Research output: Contribution to journalArticlepeer-review

  23. A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity

    Lopez, L., Bastin, M. E., Munoz-Maniega, S., Penke, L., Davies, G., Christoforou, A., Valdes Hernandez, M., Royle, N. A., Tenesa, A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Aug 2012, In: Neurobiology of Aging. 33, 8, p. 1847.e1–1847.e14 14 p.

    Research output: Contribution to journalArticlepeer-review

  24. A grid overlay framework for analysis of medical images and its application to the measurement of stroke lesions

    Armitage, P. A., Rivers, C. S., Karaszewski, B., Thomas, R. G. R., Lymer, G. K., Morris, Z. & Wardlaw, J. M., Mar 2012, In: European Radiology. 22, 3, p. 625-632 8 p.

    Research output: Contribution to journalArticlepeer-review

  25. A large margin algorithm for automated segmentation of white matter hyperintensity

    Qin, C., Guerrero, R., Bowles, C., Chen, L., Dickie, D. A., Valdes-Hernandez, M. D. C., Wardlaw, J. & Rueckert, D., 31 May 2018, In: Pattern Recognition. 77, p. 150-159 10 p.

    Research output: Contribution to journalArticlepeer-review

  26. A multimodal approach to cardiovascular risk stratification in patients with type 2 diabetes incorporating retinal, genomic and clinical features

    Fetit, A. E., Doney, A. S., Hogg, S., Wang, R., Macgillivray, T., Wardlaw, J. M., Doubal, F. N., Mckay, G. J., Mckenna, S. & Trucco, E., 5 Mar 2019, In: Scientific Reports. 9, 1, p. 3591

    Research output: Contribution to journalArticlepeer-review

  27. A new dawn of preventing dementia by preventing cerebrovascular diseases

    Pan, Y., Li, H., Wardlaw, J. M. & Wang, Y., 9 Oct 2020, In: British Medical Journal (BMJ). p. m3692

    Research output: Contribution to journalArticlepeer-review

  28. A novel genetic locus influencing retinal venular tortuosity is also associated with risk of coronary artery disease

    Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P., Relan, D., Harris, S., Brown, E., Vaidya, S. S., Dhillon, B., Zhou, K., Pearson, E. R., Hayward, C., Polasek, O., Deary, I., MacGillivray, T., Wilson, J., Trucco, E. & 2 others, Palmer, C. N. A. & Doney, A. S. F., Dec 2019, In: Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552

    Research output: Contribution to journalArticlepeer-review

  29. A pilot study of brain tumour growth between radiotherapy planning and delivery

    Pennington, C., Kilbride, L., Grant, R. & Wardlaw, J. M., Mar 2006, In: Clinical Oncology. 18, 2, p. 104-8 5 p.

    Research output: Contribution to journalArticlepeer-review

  30. A practical assessment of magnetic resonance diffusion-perfusion mismatch in acute stroke: observer variation and outcome

    Kane, I., Hand, P. J., Rivers, C., Armitage, P., Bastin, M. E., Lindley, R., Dennis, M. & Wardlaw, J. M., Nov 2009, In: Journal of Neurology. 256, 11, p. 1832-1838 7 p.

    Research output: Contribution to journalArticlepeer-review

  31. A prospective, multicentre study to investigate the efficacy, safety and tolerability of octreotide LAR (long-acting repeatable octreotide) in the primary therapy of patients with acromegaly

    Mercado, M., Borges, F., Bouterfa, H., Chang, T-C., Chervin, A., Farrall, A. J., Patocs, A., Petersenn, S., Podoba, J., Safari, M., Wardlaw, J. & SMS995B2401 Study Group, Jun 2007, In: Clinical Endocrinology. 66, 6, p. 859-68 10 p.

    Research output: Contribution to journalArticlepeer-review

  32. A structural and functional magnetic resonance imaging dataset of brain tumour patients.

    Pernet, C., Krzysztof, G., Job, D., Rodriguez Gonzalez, D., Whittle, I. & Wardlaw, J., 2 Feb 2016, In: Scientific Data. 6 p., 160003.

    Research output: Contribution to journalArticlepeer-review

  33. A systematic review of brain frontal lobe parcellation techniques in magnetic resonance imaging

    Cox, S. R., Ferguson, K. J., Royle, N. A., Shenkin, S. D., MacPherson, S. E., Maclullich, A. M. J., Deary, I. J. & Wardlaw, J. M., Jan 2014, In: Brain Structure and Function. 219, 1, p. 1-22 22 p.

    Research output: Contribution to journalArticlepeer-review

  34. A systematic review of brain metabolite changes, measured with H-1 magnetic resonance spectroscopy, in healthy aging

    Haga, K. K., Khor, Y. P., Farrall, A. & Wardlaw, J. M., Mar 2009, In: Neurobiology of Aging. 30, 3, p. 353-363 11 p.

    Research output: Contribution to journalLiterature reviewpeer-review

  35. A systematic review of the utility of 1.5 versus 3 Tesla magnetic resonance brain imaging in clinical practice and research

    Wardlaw, J. M., Brindle, W., Casado, A. M., Shuler, K., Henderson, M., Thomas, B., Macfarlane, J., Munoz-Maniega, S., Lymer, K., Morris, Z., Pernet, C., Nailon, W., Ahearn, T., Mumuni, A. N., Mugruza, C., McLean, J., Chakirova, G., Tao, Y. T., Simpson, J., Stanfield, A. C. & 9 others, Johnston, H., Parikh, J., Royle, N. A., De Wilde, J., Bastin, M. E., Weir, N., Farrall, A., Valdes Hernandez, M. C. & SINAPSE Collaborative Grp, Nov 2012, In: European Radiology. 22, 11, p. 2295-2303 9 p.

    Research output: Contribution to journalArticlepeer-review

  36. A test-retest fMRI dataset for motor, language and spatial attention functions

    Gorgolewski, K. J., Storkey, A., Bastin, M. E., Whittle, I. R., Wardlaw, J. M. & Pernet, C. R., 2013, In: GigaScience. 2, 1, 6.

    Research output: Contribution to journalArticlepeer-review

  37. A vessel for change: endothelial dysfunction in cerebral small vessel disease

    Quick, S., Moss, J., Rajani, R. M. & Williams, A. C., 8 Dec 2020, In: Trends in Neurosciences.

    Research output: Contribution to journalArticlepeer-review

  38. ABCD2 score and secondary stroke prevention. Meta-analysis and effect per 1000 patients triaged

    Wardlaw, J., Brazzelli, M., Chappell, F., Miranda, H., Shuler, K., Sandercock, P. & Dennis, M., 28 Jul 2015, In: Neurology. 85, p. 1-8

    Research output: Contribution to journalLiterature reviewpeer-review

  39. ADRB2, brain white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

    Lyall, D. M., Lopez, L. M., Bastin, M. E., Munoz-Maniega, S., Penke, L., Hernandez, M. D. C. V., Royle, N. A., Starr, J. M., Porteous, D. J., Wardlaw, J. M. & Deary, I. J., Jan 2013, In: Behavior Genetics. 43, 1, p. 13-23 11 p.

    Research output: Contribution to journalArticlepeer-review

  40. ADRB2, white matter integrity and cognitive ageing in the Lothian Birth Cohort 1936

    Lyall, D., Lopez, L., Bastin, M., Munoz-Maniega, S., Penke, L., Hernandes, M. D. V., Royle, N., Starr, J., Porteous, D., Wardlaw, J. & Deary, I., Nov 2012, In: Behavior Genetics. 42, 6, p. 949-949 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  41. APOE/TOMM40 genetic loci, white matter hyperintensities and cerebral microbleeds

    Lyall, D. M., Munoz-Maniega, S., Harris, S., Bastin, M., Murray, C., Lutz, M. W., Saunders, A. M., Roses, A. D., Valdes Hernandez, M., Royle, N., Starr, J., Porteous, D., Deary, I. & Wardlaw, J., Dec 2015, In: International Journal of Stroke. 10, 8, p. 1297-1300

    Research output: Contribution to journalArticlepeer-review

  42. Abnormal breathing patterns in stroke: relationship with location of acute stroke lesion and prior cerebrovascular disease

    Rowat, A. M., Wardlaw, J. M. & Dennis, M. S., 2007, In: Journal of Neurology, Neurosurgery & Psychiatry. 78, 3, p. 277-9 3 p.

    Research output: Contribution to journalArticlepeer-review

  43. Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group

    UK Biobank Stroke Outcomes Group, UK Biobank Follow-up and Outcomes Working Group & Wardlaw, J., 10 Sep 2015, In: PLoS ONE. 10, 9, p. e0137538

    Research output: Contribution to journalArticlepeer-review

  44. Accuracy of identifying incident stroke cases from linked healthcare data in UK Biobank

    Rannikmae, K., Ngoh, K., Bush, K., Salman, R., Doubal, F., Flaig, R., Henshall, D., Hutchison, A., Nolan, J., Osborne, S., Samarasekera, N., Schnier, C., Whiteley, W., Wilkinson, T., Wilson, K., Zhang, Q., Allen, N. & Sudlow, C., 2 Jul 2020, In: Neurology.

    Research output: Contribution to journalArticlepeer-review

  45. Accurate and reliable segmentation of the optic disc in digital fundus images

    Giachetti, A., Ballerini, L. & Trucco, E., 14 Jul 2014, In: Journal of Medical Imaging. 1, 2

    Research output: Contribution to journalArticlepeer-review

  46. Acting on incidental findings in research imaging

    Wardlaw, J. M., Davies, H., Booth, T. C., Laurie, G., Compston, A., Freeman, C., Leach, M. O., Waldman, A., Lomas, D. J., Kessler, K., Crabbe, F. & Jackson, A., 10 Nov 2015, In: British Medical Journal (BMJ). 351, p. h5190

    Research output: Contribution to journalArticlepeer-review

  47. Action Plan for Stroke in Europe 2018–2030

    Norrving, B., Barrick, J., Davalos, A., Dichgans, M., Cordonnier, C., Guekht, A., Kutluk, K., Mikulik, R., Wardlaw, J., Richard, E., Nabavi, D., Molina, C., Bath, P. M., Stibrant Sunnerhagen, K., Rudd, A., Drummond, A., Planas, A. & Caso, V., 29 Oct 2018, In: European Stroke Journal. p. 239698731880871

    Research output: Contribution to journalArticlepeer-review

  48. Activity and cognitive ageing: A healthy mind in a healthy body?

    Gow, A. J., Corley, J., Aribisala, B. S., Bastin, M. E., Starr, J. M., Wardlaw, J. M. & Deary, I. J., Aug 2012, In: Journal of Aging and Physical Activity. 20, p. S14-S14 1 p.

    Research output: Contribution to journalMeeting abstract

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