Edinburgh Research Explorer

Small Vessel Disease Research

Organisational unit: Research Group

  1. 2020
  2. Three major dimensions of human brain cortical ageing in relation to cognitive decline across the 8th decade of life

    Cox, S., Harris, M., Ritchie, S. J., Buchanan, C., Valdes Hernandez, M., Corley, J., Taylor, A., Madole, J. W., Harris, S., Whalley, H., McIntosh, A. M., Russ, T. C., Bastin, M. E., Wardlaw, J., Deary, I. & Tucker-Drob, E. M., 30 Nov 2020, (Accepted/In press) In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  3. Association of baseline hematoma and edema volumes with one-year outcome and long-term survival after spontaneous intracerebral hemorrhage: A community-based inception cohort study

    Lothian Audit of the Treatment of Cerebral Haemorrhage (LATCH) collaborators, Loan, J. J., Gane, A. B., Moullaali, T. J., Rodrigues, M. A., Wardlaw, J., Salman, R. A. & Samarasekera, N., 25 Nov 2020, In : International Journal of Stroke. p. 174749302097428

    Research output: Contribution to journalArticle

  4. Structural brain correlates of serum and epigenetic markers of inflammation in major depressive disorder

    Green, C., Shen, X., Stevenson, A. J., Conole, E. L. S., Harris, M. A., Barbu, M. C., Hawkins, E. L., Adams, M. J., Hillary, R. F., Lawrie, S. M., Evans, K. L., Walker, R. M., Morris, S. W., Porteous, D. J., Wardlaw, J. M., Douglas Steele, J., Waiter, G. D., Sandu, A., Campbell, A., Marioni, R. E. & 4 others, Cox, S. R., Cavanagh, J., Mcintosh, A. M. & Whalley, H. C., 19 Nov 2020, In : Brain, Behavior, and Immunity.

    Research output: Contribution to journalArticle

  5. Cognitive impairment in sporadic cerebral small vessel disease: A systematic review and meta-analysis

    Hamilton, O., Backhouse, E., Janssen, E., Jochems, A., Maher, C., Ritakari, T., Stevenson, A., Xia, L., Deary, I. & Wardlaw, J., 13 Nov 2020, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  6. Relationship between nitrate headache and outcome in patients with acute stroke: results from the efficacy of nitric oxide in stroke (ENOS) trial

    Beishon, L., Woodhouse, L. J., Bereczki, D., Christensen, H. K., Collins, R., Gommans, J., Kruuse, C., Ntaios, G., Ozturk, S., Phillips, S., Pocock, S., Szatmari, S., Wardlaw, J., Sprigg, N. & Bath, P. M., 5 Nov 2020, In : Stroke and Vascular Neurology. p. svn-2020-000498

    Research output: Contribution to journalArticle

  7. The association between CT biomarkers of cerebral small vessel diseases and long‐term outcome after spontaneous intracerebral hemorrhage

    Lothian Audit of the Treatment of Cerebral Haemorrhage (LATCH) collaborators, 3 Nov 2020, In : Annals of Neurology.

    Research output: Contribution to journalArticle

  8. Feasibility and diagnostic accuracy of using brain attenuation changes on CT to estimate time of ischemic stroke onset

    Mair, G., Alzahrani, A., Lindley, R. I., Sandercock, P. A. G. & Wardlaw, J. M., 30 Oct 2020, In : Neuroradiology.

    Research output: Contribution to journalArticle

  9. Intensive versus guideline‐recommended blood pressure reduction in acute lacunar stroke with intravenous thrombolysis therapy: the ENCHANTED trial

    Zhou, Z., Xia, C., Carcel, C., Yoshimura, S., Wang, X., Delcourt, C., Malavera, A., Chen, X., Mair, G., Woodward, M., Chalmers, J., Demchuk, A. M., Lindley, R. I., Robinson, T. G., Parsons, M. W., Wardlaw, J. M. & Anderson, C. S., 17 Oct 2020, In : European Journal of Neurology.

    Research output: Contribution to journalArticle

  10. Brain imaging abnormalities and outcome after acute ischaemic stroke: the ENCHANTED trial

    Delcourt, C., Wang, X., Zhou, Z., Wardlaw, J., Mair, G., Robinson, T., Chen, X., Yoshimura, S., Torii-yoshimura, T., Carcel, C., Calic, Z., Yong Tan, W., Malavera, A., Anderson, C. S. & Lindley, R. I., 14 Oct 2020, In : Journal of Neurology, Neurosurgery & Psychiatry.

    Research output: Contribution to journalArticle

  11. A new dawn of preventing dementia by preventing cerebrovascular diseases

    Pan, Y., Li, H., Wardlaw, J. M. & Wang, Y., 9 Oct 2020, In : British Medical Journal (BMJ). p. m3692

    Research output: Contribution to journalArticle

  12. Predictive Intelligence in Medicine

    Rekik, I., Adeli, E., Park, S. H. P. & Valdes Hernandez, M., 8 Oct 2020

    Research output: Book/ReportBook

  13. The glymphatic system and its role in cerebral homeostasis

    Benveniste, H., Elkin, R., Heerdt, P., Koundal, S., Xue, Y., Lee, H., Wardlaw, J. & Tannenbaum, A., 1 Oct 2020, In : Journal of Applied Physiology.

    Research output: Contribution to journalArticle

  14. Genetic correlations and genome-wide associations of cortical structure in general population samples of 22824 adults

    Hofer, E., Roshchupkin, G. V., Adams, H. H. H., Knol, M. J., Lin, H., Li, S., Zare, H., Ahmad, S., Armstrong, N. J., Satizabal, C. L., Bernard, M., Bis, J. C., Gillespie, N. A., Luciano, M., Mishra, A., Scholz, M., Teumer, A., Xia, R., Jian, X., Mosley, T. H. & 79 others, Saba, Y., Pirpamer, L., Seiler, S., Becker, J. T., Carmichael, O., Rotter, J. I., Psaty, B. M., Lopez, O. L., Amin, N., van der Lee, S. J., Yang, Q., Himali, J. J., Maillard, P., Beiser, A., DeCarli, C., Karama, S., Lewis, L., Harris, M., Bastin, M., Deary, I., Witte, A. V., Beyer, F., Loeffler, M., Mather, K. A., Schofield, P. R., Thalamuthu, A., Kwok, J. B. J., Wright, M. J., Ames, D., Trollor, J. N., Jiang, J., Brodaty, H., Wen, W., Vernooij, M. W., Hofman, A., Uitterlinden, A. G., Niessen, W. J., Wittfeld, K., Bülow, R., Völker, U., Pausova, Z., Pike, G. B., Maingault, S., Crivello, F., Tzourio, C., Amouyel, P., Mazoyer, B., Neale, M. C., Franz, C. E., Lyons, M. J., Panizzon, M. S., Andreassen, O. A., Dale, A. M., Logue, M. A., Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-Conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Stein, J. L., Thompson, P., Medland, S. E., Sachdev, P. S., Kremen, W. S., Wardlaw, J., Villringer, A., van Duijn, C., Grabe, H. J., Longstreth, W. T., Fornage, M., Paus, T., Debette, S., Ikram, M. A., Schmidt, H., Schmidt, R. & Seshadri, S., 22 Sep 2020, In : Nature Communications. 11, 4796 .

    Research output: Contribution to journalArticle

  15. 4D flow MRI for non-invasive measurement of blood flow in the brain: A systematic review

    Morgan, A. G., Thrippleton, M. J., Wardlaw, J. M. & Marshall, I., 16 Sep 2020, In : Journal of Cerebral Blood Flow and Metabolism. p. 0271678X2095201

    Research output: Contribution to journalArticle

  16. A Review of Translational Magnetic Resonance Imaging in Human and Rodent Experimental Models of Small Vessel Disease

    Stringer, M. S., Lee, H., Huuskonen, M. T., Macintosh, B. J., Brown, R., Montagne, A., Atwi, S., Ramirez, J., Jansen, M. A., Marshall, I., Black, S. E., Zlokovic, B. V., Benveniste, H. & Wardlaw, J. M., 16 Sep 2020, In : Translational Stroke Research.

    Research output: Contribution to journalArticle

  17. Association of common genetic variants with brain microbleeds: A genome-wide association study

    Knol, M. J., Lu, D., Traylor, M., Adams, H. H. H., Rafael Romero, J., Smith, A. V., Fornage, M., Hofer, E., Liu, J., Hostettler, I., Luciano, M., Trompet, S., Giese, A-K., Hilal, S., van den Akker, E., Vojinovic, D., Li, S., Sigurdsson, S., van der Lee, S., Jack, C. R. & 43 others, Wilson, D., Yilmaz, P., Satizabal, C. L., Liewald, D., van der Grond, J., Chen, C., Saba, Y., van der Lugt, A., Bastin, M., Windham, B. G., Cheng, C-Y., Pirpamer, L., Kantarci, K., Himali, J. J., Yang, Q., Morris, Z., Beiser, A., Tozer, D. J., Vernooij, M. W., Amin, N., Beekman, M., Koh, J. Y., Stott, D., Houlden, H., Schmidt, R., Gottesman, R. F., Mackinnon, A., Decarli, C., Gudnason, V., Deary, I., van Duijn, C., Slagboom, P. E., Wong, T. Y., Rost, N., Wouter Jukema, J., Mosley, T. H., Werring, D., Schmidt, H., Wardlaw, J., Ikram, M. A., Seshadri, S., Lenore, L. J. & Markus, H. S., 10 Sep 2020, In : Neurology.

    Research output: Contribution to journalArticle

  18. Cerebral small vessel disease genomics and its implications across the lifespan

    Sargurupremraj, M., Suzuki, H., Jian, X., Sarnowski, C., Evans, T. E., Bis, J. C., Eiriksdottir, G., Sakaue, S., Terzikhan, N., Habes, M., Zhao, W., Armstrong, N. J., Hofer, E., Yanek, L. R., Hagenaars, S., Rajan, K. B., van den Akker, E., McWhirter, R. E., Trompet, S., Mishra, A. & 97 others, Saba, Y., Satizabal, C. L., Beaudet, G., Petit, L., Tsuchida, A., Zago, L., Schilling, S., Sigurdsson, S., Gottesman, R. F., Lewis, C. E., Aggarwal, N. T., Lopez, O. L., Smith, J. A., Valdes Hernandez, M., van der Grond, J., Wright, M. J., Knol, M. J., Dörr, M., Thomson, R., Bordes, C., Le Grand, Q., Duperron, M-G., Smith, A. V., Knopman, D. S., Schreiner, P. J., Evans, D. A., Rotter, J. I., Beiser, A. S., Muñoz Maniega, S., Beekman, M., Trollor, J. N., Stott, D. J., Vernooij, M. W., Wittfield, K., Niessen, W. J., Soumaré, A., Boerwinkle, E., Sidney, S. S., Turner, S. T., Davies, G., Thalamuthu, A., Völker, U., Van Buchem, M. A., Bryan, R. N., Dupuis, J., Bastin, M., Ames, D., Teumer, A., Amouyel, P., Kwok, J. B. J., Bülow, R., Deary, I., Schofield, P. R., Brodaty, H., Jiang, J., Tabara, Y., Setoh, K., Miyamoto, S., Yoshida, K., Nagata, M., Kamatani, Y., Matsuda, F., Psaty, B. M., Bennett, D. A., De Jager, P. L., Mosley, T. H., Sachdev, P. S., Schmidt, R., Warren, H. R., Evangelou, E., Trégouët, D. A., Ikram, M. A., Wen, W., DeCarli, C., Srikanth, V. K., Wouter Jukema, J., Slagboom, P. E., Kardia, S. L. R., Okada, Y., Mazoyer, B., Wardlaw, J., Nyquist, P. A., Mather, K. A., Grabe, H. J., Schmidt, H., van Duijn, C., Gudnason, V., Longstreth, W. T., Lenore, L. J., Lathrop, G. M., Campbell, A., Seshadri, S., Tzourio, C., Adams, H. H. H., Matthews, P. M., Fornage, M. & Debette, S., 10 Sep 2020, (Accepted/In press) In : Nature Communications.

    Research output: Contribution to journalArticle

  19. Quantitative measurements of enlarged perivascular spaces in the brain are associated with retinal microvascular parameters in older community-dwelling subjects

    Ballerini, L., McGrory, S., Valdes Hernandez, M., Lovreglio, R., Pellegrini, E., MacGillivray, T., Muñoz Maniega, S., Henderson, R., Taylor, A., Bastin, M., Doubal, F., Trucco, E., Deary, I. & Wardlaw, J., 21 Aug 2020, In : Cerebral Circulation—Cognition and Behavior. 1, 100002.

    Research output: Contribution to journalArticle

  20. Diffuse white matter loss in a transgenic rat model of cerebral amyloid angiopathy

    Lee, H., Xu, F., Liu, X., Koundal, S., Zhu, X., Davis, J., Yanez, D., Schrader, J., Stanisavljevic, A., Rothman, D. L., Wardlaw, J., Van Nostrand, W. E. & Benveniste, H., 13 Aug 2020, In : Journal of Cerebral Blood Flow and Metabolism. p. 0271678X2094422

    Research output: Contribution to journalArticle

  21. Tackling challenges in care of Alzheimer's disease and other dementias amid the COVID‐19 pandemic, now and in the future

    Mok, V. C. T., Pendlebury, S., Wong, A., Alladi, S., Au, L., Bath, P. M., Biessels, G. J., Chen, C., Cordonnier, C., Dichgans, M., Dominguez, J., Gorelick, P. B., Kim, S., Kwok, T., Greenberg, S. M., Jia, J., Kalaria, R., Kivipelto, M., Naegandran, K., Lam, L. C. W. & 15 others, Lam, B. Y. K., Lee, A. T. C., Markus, H. S., O'brien, J., Pai, M., Pantoni, L., Sachdev, P., Skoog, I., Smith, E. E., Srikanth, V., Suh, G., Wardlaw, J., Ko, H., Black, S. E. & Scheltens, P., 12 Aug 2020, In : Alzheimer's & Dementia.

    Research output: Contribution to journalArticle

  22. Cilostazol for Secondary Prevention of Stroke and Cognitive Decline: Systematic Review and Meta-Analysis

    Mchutchison, C., Blair, G. W., Appleton, J. P., Chappell, F. M., Doubal, F., Bath, P. M. & Wardlaw, J. M., 10 Jul 2020, In : Stroke. 51, 8, p. 2374-2385

    Research output: Contribution to journalArticle

  23. A Framework for Jointly Assessing and Reducing Imaging Artefacts Automatically Using Texture Analysis and Total Variation Optimisation for Improving Perivascular Spaces Quantification in Brain Magnetic Resonance Imaging

    Bernal, J., Valdés-hernández, M., Ballerini, L., Escudero, J., Jochems, A. C. C., Clancy, U., Doubal, F. N., Stringer, M. S., Thrippleton, M. J., Touyz, R. M. & Wardlaw, J. M., 8 Jul 2020, Conference on Medical Image Understanding and Analysis (MIUA) 2020. Springer, Vol. 1248. p. 171-183 Chapter 14. (Medical Image Understanding and Analysis; vol. 1248).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  24. Retinal Biomarkers Discovery for Cerebral Small Vessel Disease in an Older Population

    Ballerini, L., Fetit, A. E., Wunderlich, S., Lovreglio, R., Mcgrory, S., Valdes-hernandez, M., Macgillivray, T., Doubal, F., Deary, I. J., Wardlaw, J. & Trucco, E., 8 Jul 2020, Medical Image Understanding and Analysis. MIUA 2020. Communications in Computer and Information Science. Papież, B., Namburete, A., Yaqub, M. & Noble, J. (eds.). Springer, p. 400-409 Chapter 31. (Medical Image Understanding and Analysis; vol. 1248).

    Research output: Chapter in Book/Report/Conference proceedingChapter

  25. Accuracy of identifying incident stroke cases from linked healthcare data in UK Biobank

    Rannikmae, K., Ngoh, K., Bush, K., Salman, R., Doubal, F., Flaig, R., Henshall, D., Hutchison, A., Nolan, J., Osborne, S., Samarasekera, N., Schnier, C., Whiteley, W., Wilkinson, T., Wilson, K., Zhang, Q., Allen, N. & Sudlow, C., 2 Jul 2020, In : Neurology.

    Research output: Contribution to journalArticle

  26. Automatic Spatial Estimation of White Matter Hyperintensities Evolution in Brain MRI using Disease Evolution Predictor Deep Neural Networks

    Rachmadi, M. F., Valdés-hernández, M. D. C., Makin, S., Wardlaw, J. & Komura, T., 1 Jul 2020, In : Medical image analysis. 63, 101712.

    Research output: Contribution to journalArticle

  27. Thrombolysis Outcomes in Acute Ischemic Stroke by Fluid-Attenuated Inversion Recovery Hyperintense Arteries

    Zhou, Z., Yoshimura, S., Delcourt, C., Lindley, R. I., You, S., Malavera, A., Torii-yoshimura, T., Carcel, C., Wang, X., Chen, X., Parsons, M. W., Demchuk, A. M., Wardlaw, J. M., Mair, G., Robinson, T. G., Chalmers, J., Xu, J. & Anderson, C. S., 17 Jun 2020, In : Stroke. 51, 7, p. 2240-2243

    Research output: Contribution to journalArticle

  28. Aging-sensitive networks within the human structural connectome are implicated in late-life cognitive declines.

    Madole, J. W., Ritchie, S. J., Cox, S., Buchanan, C., Valdes Hernandez, M., Muñoz Maniega, S., Wardlaw, J., Harris, M., Bastin, M., Deary, I. & Tucker-Drob, E. M., 15 Jun 2020, In : Biological Psychiatry.

    Research output: Contribution to journalArticle

  29. Reporting "specific abilities" after major stroke to better describe prognosis

    Visvanathan, A., Whiteley, W., Mead, G., Lawton, J., Doubal, F. N. & Dennis, M., 13 Jun 2020, In : Journal of Stroke and Cerebrovascular Diseases. 29, 8, p. 104993

    Research output: Contribution to journalArticle

  30. Common Genetic Variation Indicates Separate Causes for Periventricular and Deep White Matter Hyperintensities

    Armstrong, N. J., Mather, K. A., Sargurupremraj, M., Knol, M. J., Malik, R., Satizabal, C. L., Yanek, L. R., Wen, W., Gudnason, V. G., Dueker, N. D., Elliott, L. T., Hofer, E., Bis, J., Jahanshad, N., Li, S., Logue, M. A., Luciano, M., Scholz, M., Smith, A. V., Trompet, S. & 66 others, Vojinovic, D., Xia, R., Alfaro-almagro, F., Ames, D., Amin, N., Amouyel, P., Beiser, A. S., Brodaty, H., Deary, I. J., Fennema-notestine, C., Gampawar, P. G., Gottesman, R., Griffanti, L., Jack, C. R., Jenkinson, M., Jiang, J., Kral, B. G., Kwok, J. B., Lampe, L., C.m. Liewald, D., Maillard, P., Marchini, J., Bastin, M. E., Mazoyer, B., Pirpamer, L., Rafael Romero, J., Roshchupkin, G. V., Schofield, P. R., Schroeter, M. L., Stott, D. J., Thalamuthu, A., Trollor, J., Tzourio, C., Van Der Grond, J., Vernooij, M. W., Witte, V. A., Wright, M. J., Yang, Q., Morris, Z., Siggurdsson, S., Psaty, B., Villringer, A., Schmidt, H., Haberg, A. K., Van Duijn, C. M., Jukema, J. W., Dichgans, M., Sacco, R. L., Wright, C. B., Kremen, W. S., Becker, L. C., Thompson, P. M., Mosley, T. H., Wardlaw, J. M., Ikram, M. A., Adams, H. H. H., Seshadri, S., Sachdev, P. S., Smith, S. M., Launer, L., Longstreth, W., Decarli, C., Schmidt, R., Fornage, M., Debette, S. & Nyquist, P. A., 10 Jun 2020, In : Stroke.

    Research output: Contribution to journalArticle

  31. Rationale and design of a longitudinal study of cerebral small vessel diseases, clinical and imaging outcomes in patients presenting with mild ischaemic stroke: Mild Stroke Study 3

    Clancy, U., Garcia, D. J., Stringer, M. S., Thrippleton, M. J., Valdés-hernández, M. C., Wiseman, S., Hamilton, O. K., Chappell, F. M., Brown, R., Blair, G. W., Hewins, W., Sleight, E., Ballerini, L., Bastin, M. E., Maniega, S. M., Macgillivray, T., Hetherington, K., Hamid, C., Arteaga, C., Morgan, A. G. & 7 others, Manning, C., Backhouse, E., Hamilton, I., Job, D., Marshall, I., Doubal, F. N. & Wardlaw, J. M., 5 Jun 2020, In : European Stroke Journal. p. 239698732092961

    Research output: Contribution to journalArticle

  32. Age-Related Changes of Peak Width Skeletonized Mean Diffusivity (PSMD) Across the Adult Lifespan: A Multi-Cohort Study

    Beaudet, G., Tsuchida, A., Petit, L., Tzourio, C., Caspers, S., Schreiber, J., Pausova, Z., Patel, Y., Paus, T., Schmidt, R., Pirpamer, L., Sachdev, P. S., Brodaty, H., Kochan, N. A., Trollor, J. N., Wen, W., Armstrong, N. J., Deary, I., Bastin, M., Wardlaw, J. & 6 others, Muñoz Maniega, S., Witte, A. V., Villringer, A., Duering, M., Debette, S. & Mazoyer, B., 4 May 2020, In : Frontiers in psychiatry. 11, 342.

    Research output: Contribution to journalArticle

  33. Protocol: The Lacunar Intervention Trial 2 (LACI-2). A trial of two repurposed licenced drugs to prevent progression of cerebral small vessel disease

    Wardlaw, J., Bath, P. M. W., Doubal, F., Heye, A., Sprigg, N., Woodhouse, L. J., Blair, G., Appleton, J., Cvoro, V., England, T., Hassan, A., John Werring, D. & Montgomery, A., 20 Apr 2020, In : European Stroke Journal. p. 239698732092011

    Research output: Contribution to journalArticle

  34. Improving Clinical Detection of Acute Lacunar Stroke: Analysis From the IST-3

    Arba, F., Mair, G., Phillips, S., Sandercock, P. & Wardlaw, J. M., 9 Apr 2020, In : Stroke.

    Research output: Contribution to journalArticle

  35. Clinical prognosis of FLAIR hyperintense arteries in ischaemic stroke patients: a systematic review and meta-analysis

    Zhou, Z., Malavera, A., Yoshimura, S., Delcourt, C., Mair, G., Al-shahi Salman, R., Demchuk, A. M., Wardlaw, J. M., Lindley, R. I. & Anderson, C. S., 26 Mar 2020, In : Journal of Neurology, Neurosurgery & Psychiatry. p. jnnp-2019-322625

    Research output: Contribution to journalArticle

  36. Global and regional development of the human cerebral cortex: Molecular architecture and occupational aptitudes

    ENIGMA Consortium & neuroCHARGE Cognitive Working group, 20 Mar 2020, In : Cerebral Cortex. bhaa035.

    Research output: Contribution to journalArticle

  37. The genetic architecture of the human cerebral cortex

    Grasby, K. L., Jahanshad, N., Painter, J. N., Colodro-conde, L., Bralten, J., Hibar, D. P., Lind, P. A., Pizzagalli, F., Ching, C. R. K., Mcmahon, M. A. B., Shatokhina, N., Zsembik, L. C. P., Thomopoulos, S. I., Zhu, A. H., Strike, L. T., Agartz, I., Alhusaini, S., Almeida, M. A. A., Alnæs, D., Amlien, I. K. & 340 others, Andersson, M., Ard, T., Armstrong, N. J., Ashley-koch, A., Atkins, J. R., Bernard, M., Brouwer, R. M., Buimer, E. E. L., Bülow, R., Bürger, C., Cannon, D. M., Chakravarty, M., Chen, Q., Cheung, J. W., Couvy-duchesne, B., Dale, A. M., Dalvie, S., De Araujo, T. K., De Zubicaray, G. I., De Zwarte, S. M. C., Den Braber, A., Doan, N. T., Dohm, K., Ehrlich, S., Engelbrecht, H., Erk, S., Fan, C. C., Fedko, I. O., Foley, S. F., Ford, J. M., Fukunaga, M., Garrett, M. E., Ge, T., Giddaluru, S., Goldman, A. L., Green, M. J., Groenewold, N. A., Grotegerd, D., Gurholt, T. P., Gutman, B. A., Hansell, N. K., Harris, M. A., Harrison, M. B., Haswell, C. C., Hauser, M., Herms, S., Heslenfeld, D. J., Ho, N. F., Hoehn, D., Hoffmann, P., Holleran, L., Hoogman, M., Hottenga, J., Ikeda, M., Janowitz, D., Jansen, I. E., Jia, T., Jockwitz, C., Kanai, R., Karama, S., Kasperaviciute, D., Kaufmann, T., Kelly, S., Kikuchi, M., Klein, M., Knapp, M., Knodt, A. R., Krämer, B., Lam, M., Lancaster, T. M., Lee, P. H., Lett, T. A., Lewis, L. B., Lopes-cendes, I., Luciano, M., Macciardi, F., Marquand, A. F., Mathias, S. R., Melzer, T. R., Milaneschi, Y., Mirza-schreiber, N., Moreira, J. C. V., Mühleisen, T. W., Müller-myhsok, B., Najt, P., Nakahara, S., Nho, K., Olde Loohuis, L. M., Orfanos, D. P., Pearson, J. F., Pitcher, T. L., Pütz, B., Quidé, Y., Ragothaman, A., Rashid, F. M., Reay, W. R., Redlich, R., Reinbold, C. S., Repple, J., Richard, G., Riedel, B. C., Risacher, S. L., Rocha, C. S., Mota, N. R., Salminen, L., Saremi, A., Saykin, A. J., Schlag, F., Schmaal, L., Schofield, P. R., Secolin, R., Shapland, C. Y., Shen, L., Shin, J., Shumskaya, E., Sønderby, I. E., Sprooten, E., Tansey, K. E., Teumer, A., Thalamuthu, A., Tordesillas-gutiérrez, D., Turner, J. A., Uhlmann, A., Vallerga, C. L., Van Der Meer, D., Van Donkelaar, M. M. J., Van Eijk, L., Van Erp, T. G. M., Van Haren, N. E. M., Van Rooij, D., Van Tol, M., Veldink, J. H., Verhoef, E., Walton, E., Wang, M., Wang, Y., Wardlaw, J. M., Wen, W., Westlye, L. T., Whelan, C. D., Witt, S. H., Wittfeld, K., Wolf, C., Wolfers, T., Wu, J. Q., Yasuda, C. L., Zaremba, D., Zhang, Z., Zwiers, M. P., Artiges, E., Assareh, A. A., Ayesa-arriola, R., Belger, A., Brandt, C. L., Brown, G. G., Cichon, S., Curran, J. E., Davies, G. E., Degenhardt, F., Dennis, M. F., Dietsche, B., Djurovic, S., Doherty, C. P., Espiritu, R., Garijo, D., Gil, Y., Gowland, P. A., Green, R. C., Häusler, A. N., Heindel, W., Ho, B., Hoffmann, W. U., Holsboer, F., Homuth, G., Hosten, N., Jack, C. R., Jang, M., Jansen, A., Kimbrel, N. A., Kolskår, K., Koops, S., Krug, A., Lim, K. 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J., Caseras, X., Caspers, S., Cavalleri, G. L., Cendes, F., Corvin, A., Crespo-facorro, B., Dalrymple-alford, J. C., Dannlowski, U., De Geus, E. J. C., Deary, I. J., Delanty, N., Depondt, C., Desrivières, S., Donohoe, G., Espeseth, T., Fernández, G., Fisher, S. E., Flor, H., Forstner, A. J., Francks, C., Franke, B., Glahn, D. C., Gollub, R. L., Grabe, H. J., Gruber, O., Håberg, A. K., Hariri, A. R., Hartman, C. A., Hashimoto, R., Heinz, A., Henskens, F. A., Hillegers, M. H. J., Hoekstra, P. J., Holmes, A. J., Hong, L. E., Hopkins, W. D., Hulshoff Pol, H. E., Jernigan, T. L., Jönsson, E. G., Kahn, R. S., Kennedy, M. A., Kircher, T. T. J., Kochunov, P., Kwok, J. B. J., Le Hellard, S., Loughland, C. M., Martin, N. G., Martinot, J., Mcdonald, C., Mcmahon, K. L., Meyer-lindenberg, A., Michie, P. T., Morey, R. A., Mowry, B., Nyberg, L., Oosterlaan, J., Ophoff, R. A., Pantelis, C., Paus, T., Pausova, Z., Penninx, B. W. J. H., Polderman, T. J. C., Posthuma, D., Rietschel, M., Roffman, J. L., Rowland, L. M., Sachdev, P. S., Sämann, P. G., Schall, U., Schumann, G., Scott, R. J., Sim, K., Sisodiya, S. M., Smoller, J. W., Sommer, I. E., St Pourcain, B., Stein, D. J., Toga, A. W., Trollor, J. N., Van Der Wee, N. J. A., Van ’t Ent, D., Völzke, H., Walter, H., Weber, B., Weinberger, D. R., Wright, M. J., Zhou, J., Stein, J. L., Thompson, P. M. & Medland, S. E., 20 Mar 2020, In : Science. 367, 6484, eaay6690.

    Research output: Contribution to journalArticle

  38. Opening the floodgates to the brain

    Moss, J. & Williams, A., 13 Mar 2020, Science.

    Research output: Book/ReportCommissioned report

  39. DNA methylation and brain structure and function across the life course: a systematic review

    Wheater, E. N. W., Stoye, D. Q., Cox, S. R., Wardlaw, J. M., Drake, A. J., Bastin, M. E. & Boardman, J. P., 6 Mar 2020, In : Neuroscience and Biobehavioral Reviews.

    Research output: Contribution to journalArticle

  40. Efficacy of three neuroprotective drugs in secondary progressive multiple sclerosis (MS-SMART): a phase 2b, multiarm, double-blind, randomised placebo-controlled trial

    MS -SMART Investigators, Mar 2020, In : The Lancet Neurology.

    Research output: Contribution to journalArticle

  41. Relationship between neuropsychiatric disorders and cognitive and behavioural change in MND

    McHutchison, C. A., Leighton, D. J., McIntosh, A., Cleary, E., Warner, J., Porteous, M., Chandran, S., Pal, S. & Abrahams, S., Mar 2020, In : Journal of Neurology, Neurosurgery & Psychiatry. 91, 3, p. 245-253

    Research output: Contribution to journalArticle

  42. Polygenic architecture of human neuroanatomical diversity

    Biton, A., Traut, N., Poline, J. B., Aribsala, B., Bastin, M., Bülow, R., Cox, S., Deary, I., Fukunaga, M., Grabe, H. J., Hagenaars, S., Hashimoto, R., Kikuchi, M., Muñoz Maniega, S., Nauck, M., Royle, N., Teumer, A., Valdes Hernandez, M., Völker, U., Wardlaw, J. & 4 others, Wittfield, K., Yamamori, H., Bourgeron, T. & Toro, R., 28 Feb 2020, In : Cerebral Cortex. bhz241.

    Research output: Contribution to journalArticle

  43. Publisher Correction: Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

    Koundal, S., Elkin, R., Nadeem, S., Xue, Y., Constantinou, S., Sanggaard, S., Liu, X., Monte, B., Xu, F., Nostrand, W. V., Nedergaard, M., Lee, H., Wardlaw, J., Benveniste, H. & Tannenbaum, A., 27 Feb 2020, In : Scientific Reports. 10, 1

    Research output: Contribution to journalArticle

  44. Perivascular spaces in the brain: anatomy, physiology and pathology

    Wardlaw, J. M., Benveniste, H., Nedergaard, M., Zlokovic, B. V., Mestre, H., Lee, H., Doubal, F. N., Brown, R., Ramirez, J., Macintosh, B. J., Tannenbaum, A., Ballerini, L., Rungta, R. L., Boido, D., Sweeney, M., Montagne, A., Charpak, S., Joutel, A., Smith, K. J. & Black, S. E., 24 Feb 2020, In : Nature Reviews Neurology.

    Research output: Contribution to journalArticle

  45. Neurology-related protein biomarkers are associated with cognitive ability and brain volume in older age

    Harris, S., Cox, S., Bell, S., Marioni, R., Prins, B. P., Pattie, A., Corley, J., Muñoz Maniega, S., Valdes Hernandez, M., Morrison, Z., John, S. L., Bronson, P. G., Tucker-Drob, E. M., Starr, J., Bastin, M., Wardlaw, J., Butterworth, A. S. & Deary, I., 10 Feb 2020, In : Nature Communications. 11, 800.

    Research output: Contribution to journalArticle

  46. Optimal Mass Transport with Lagrangian Workflow Reveals Advective and Diffusion Driven Solute Transport in the Glymphatic System

    Kounda, S., Elkin, R., Nadeem, S., Xue, Y., Constantinou, S., Sanggaard, S., Liu, X., Monte, B., Xu, F., Van Nostrand, W., Nedergaard, M., Lee, H., Wardlaw, J., Benveniste, H. & Tannenbaum, A., 6 Feb 2020, In : Scientific Reports. 10, 1

    Research output: Contribution to journalArticle

  47. Fluctuating asymmetry in brain structure and general intelligence in 73-Year-olds

    Moodie, J. E., Ritchie, S., Cox, S., Harris, M., Muñoz Maniega, S., Valdes Hernandez, M., Pattie, A., Corley, J., Bastin, M., Starr, J., Wardlaw, J. & Deary, I., 31 Jan 2020, In : Intelligence. 78, 101407.

    Research output: Contribution to journalArticle

  48. Analysis of spatial spectral features of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

    Bernal Moyano, J., Valdes Hernandez, M., Escudero, J., Armitage, P., Makin, S., Touyz, R. M. & Wardlaw, J., 24 Jan 2020, Medical Image Understanding and Analysis. MIUA 2019. Communications in Computer and Information Science. Springer, Vol. 1065.

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  49. Brain hyperintensities in magnetic resonance imaging of patients with mild acute focal neurology

    Varsou, O., Turnbull, K., Stringer, M. S., Fernandes, C. D., Murray, A. D., Schwarzbauer, C. & Macleod, M. J., 23 Jan 2020, In : Neurological Sciences.

    Research output: Contribution to journalArticle

  50. Cerebral small vessel disease: Potential interventions for prevention and treatment

    Blair, G., Appleton, J. P., Wardlaw, J. & Bath, P., 15 Jan 2020, Stroke in the Older Person. Oxford University Press

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)

  51. Sleep and brain morphological changes in the eighth decade of life

    Aribisala, B. S., Riha, R. L., Valdes Hernandez, M., Maniega, S. M., Cox, S., Radakovic, R., Taylor, A., Pattie, A., Corley, J., Redmond, P., Bastin, M. E., Starr, J., Deary, I. & Wardlaw, J. M., Jan 2020, In : Sleep medicine. 65

    Research output: Contribution to journalArticle

  52. White matter hyperintensities mediate the association between blood-brain barrier leakage and information processing speed

    Freeze, W. M., Jacobs, H. I. L., De Jong, J. J., Verheggen, I. C. M., Gronenschild, E. H. B. M., Palm, W. M., Hoff, E. I., Wardlaw, J. M., Jansen, J. F. A., Verhey, F. R. & Backes, W. H., Jan 2020, In : Neurobiology of Aging. 85

    Research output: Contribution to journalArticle

  53. 2019
  54. The striatum, the hippocampus, and short-term memory binding: Volumetric analysis of the subcortical grey matter’s role in mild cognitive impairment

    Valdes Hernandez, M., Clark, R., Wang, S-H., Guazzo, F., Calia, C., Pattan, V., Della Sala, S. & Parra, M. A., 29 Dec 2019, In : NeuroImage: Clinical. 25

    Research output: Contribution to journalArticle

  55. Imaging markers of small vessel disease and ‘brain frailty’ and outcomes in acute stroke

    ENOS Investigators, Appleton, J. P., Woodhouse, L., Adami, A., Becker, J. L., Berge, E., Cala, L. A., Casado, A. M., Caso, V., Christensen, H., Dineen, R. A., Gommans, J., Koumellis, P., Szatmari, S., Sprigg, N., Bath, P. M. & Wardlaw, J., 27 Dec 2019, In : Neurology.

    Research output: Contribution to journalArticle

  56. Epigenome-wide meta-analyses of blood DNA methylation and its association with subcortical volumes: Findings from the ENIGMA Epigenetics Working Group

    Jia, T., Chu, C., Liu, Y., van Dongen, J., Papastergios, E., Armstrong, N. J., Bastin, M., Carrillo-roa, T., den Braber, A., Harris, M., Jansen, R., Liu, J., Luciano, M., Ori, A. P. S., Roiz-Santianez, R., Ruggeri, B., Sarkisyan, D., Shin, J., Sungeun, K., Tordesillas-Gutierrez, D. & 62 others, Van't Ent, D., Ames, D., Artiges, E., Bakalkin, G., Banaschewski, T., Bokde, A. L. W., Brodaty, H., Bromberg, U., Brouwer, R. M., Büchel, C., Quinlan, E. B., Cahn, W., de Zubicaray, G. I., Ehrlich, S., Ekström, T. J., Flor, H., Fröhner, J. H., Frouin, V., Garavan, H., Gowland, P. A., Heinz, A., Hoare, J., Ittermann, B., Jahanshad, N., Jiang, J., Kwok, J. B. J., Martin, N. G., Martinot, J-L., Mather, K. A., McMahon, K. L., Mcrae, A. F., Nees, F., Papadopoulos Orfanos, D., Paus, T., Poustka, L., Sämann, P. G., Schofield, P. R., Smolka, M. N., Stein, D. J., Strike, L. T., Teeuw, J., Thalamuthu, A., Trollor, J. N., Walter, H., Wardlaw, J., Wen, W., Whelan, R., Apostolova, L. G., Binder, E. B., Boomsma, D., Calhoun, V. D., Crespo-Facorro, B., Deary, I., Hulshoff Pol, H. E., Ophoff, R. A., Pausova, Z., Sachdev, P. S., Saykin, A. J., Wright, M. J., Thompson, P. M., Schumann, G. & Desrivières, S., 6 Dec 2019, In : Molecular Psychiatry.

    Research output: Contribution to journalArticle

  57. An epigenetic predictor of death captures multi-modal measures of brain health

    Hillary, R. F., Stevenson, A. J., Cox, S. R., McCartney, D. L., Harris, S. E., Seeboth, A., Higham, J., Sproul, D., Taylor, A. M., Redmond, P., Corley, J., Pattie, A., del C. Valdés Hernández, M., Muñoz-Maniega, S., Bastin, M. E., Wardlaw, J., Horvath, S., Ritchie, C. W., Spires-Jones, T. L., McIntosh, A. M. & 3 others, Evans, K. L., Deary, I. & Marioni, R. E., 3 Dec 2019, In : Molecular Psychiatry. 11 p.

    Research output: Contribution to journalArticle

  58. A novel genetic locus influencing retinal venular tortuosity is also associated with risk of coronary artery disease

    Veluchamy, A., Ballerini, L., Vitart, V., Schraut, K. E., Kirin, M., Campbell, H., Joshi, P., Relan, D., Harris, S., Brown, E., Vaidya, S. S., Dhillon, B., Zhou, K., Pearson, E. R., Hayward, C., Polasek, O., Deary, I., MacGillivray, T., Wilson, J., Trucco, E. & 2 others, Palmer, C. N. A. & Doney, A. S. F., Dec 2019, In : Arteriosclerosis, Thrombosis, and Vascular Biology. 39, 12, p. 2542-2552

    Research output: Contribution to journalArticle

  59. Retinal microvascular features and cognitive change in the Lothian Birth Cohort 1936

    McGrory, S., Ballerini, L., Okely, J., Ritchie, S., Doubal, F., Doney, A. S. F., Starr, J., MacGillivray, T., Trucco, E., Wardlaw, J. & Deary, I., Dec 2019, In : Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 11, p. 500-509 10 p.

    Research output: Contribution to journalArticle

  60. Limited One-time Sampling Irregularity Map (LOTS-IM) for Automatic Unsupervised Assessment of White Matter Hyperintensities and Multiple Sclerosis Lesions in Structural Brain Magnetic Resonance Images

    Rachmadi, M. F., Del C. Valdés-hernández, M., Li, H., Guerrero, R., Meijboom, R., Wiseman, S., Waldman, A., Zhang, J., Rueckert, D., Wardlaw, J. & Komura, T., 27 Nov 2019, In : Computerized Medical Imaging and Graphics. 79, 101685.

    Research output: Contribution to journalArticle

  61. Preventing foot ulceration in diabetes: systematic review and meta-analyses of RCT data

    Crawford, F., Nicolson, D. J., Amanna, A. E., Martin, A., Gupta, S., Leese, G. P., Heggie, R., Chappell, F. M. & Mcintosh, H. H., 27 Nov 2019, In : Diabetologia. 63, 1, p. 49-64

    Research output: Contribution to journalArticle

  62. Brain atrophy in cerebral small vessel diseases: Extent, consequences, technical limitations and perspectives: The HARNESS initiative

    De Guio, F., Duering, M., Fazekas, F., De Leeuw, F., Greenberg, S. M., Pantoni, L., Aghetti, A., Smith, E. E., Wardlaw, J. & Jouvent, E., 20 Nov 2019, In : Journal of Cerebral Blood Flow and Metabolism. p. 0271678X1988896

    Research output: Contribution to journalReview article

  63. Three-Dimensional Shape Modeling and Analysis of Brain Structures

    Kim, J., Valdés Hernández, M. D. C. & Park, J., 14 Nov 2019, In : Journal of Visualized Experiments. 153

    Research output: Contribution to journalArticle

  64. Analysis of dynamic texture and spatial spectral descriptors of dynamic contrast-enhanced brain magnetic resonance images for studying small vessel disease

    Bernal, J., Valdés-hernández, M. D. C., Escudero, J., Viksne, L., Heye, A. K., Armitage, P. A., Makin, S., Touyz, R. M. & Wardlaw, J. M., 13 Nov 2019, In : Magnetic Resonance Imaging.

    Research output: Contribution to journalArticle

  65. Profile of and risk factors for poststroke cognitive impairment in diverse ethno-regional groups

    for the Stroke and Cognition (STROKOG) Collaboration, 11 Nov 2019, In : Neurology. p. 10.1212/WNL.0000000000008612

    Research output: Contribution to journalArticle

  66. Predictors of Lesion Cavitation After Recent Small Subcortical Stroke

    Gattringer, T., Valdes Hernandez, M., Heye, A., Armitage, P. A., Makin, S., Chappell, F., Pinter, D., Doubal, F., Enzinger, C., Fazekas, F. & Wardlaw, J. M., 8 Nov 2019, In : Translational Stroke Research.

    Research output: Contribution to journalArticle

  67. Modelling Direct Brain Cooling for Acute Ischaemic Stroke with the Vascular-Porous Model

    Fulford, L., Marshall, I., Andrews, P. & Valluri, P., Nov 2019.

    Research output: Contribution to conferenceAbstract

  68. Genetic architecture of subcortical brain structures in 38,851 individuals

    Satizabal, C. L., Adams, H. H. H., Hibar, D. P., White, C. C., Knol, M. J., Stein, J. L., Scholz, M., Sargurupremraj, M., Jahanshad, N., Roshchupkin, G. V., Smith, A. V., Bis, J. C., Jian, X., Luciano, M., Hofer, E., Teumer, A., Van Der Lee, S. J., Yang, J., Yanek, L. R., Lee, T. V. & 269 others, Li, S., Hu, Y., Koh, J. Y., Eicher, J. D., Desrivières, S., Arias-vasquez, A., Chauhan, G., Athanasiu, L., Rentería, M. E., Kim, S., Hoehn, D., Armstrong, N. J., Chen, Q., Holmes, A. J., Den Braber, A., Kloszewska, I., Andersson, M., Espeseth, T., Grimm, O., Abramovic, L., Alhusaini, S., Milaneschi, Y., Papmeyer, M., Axelsson, T., Ehrlich, S., Roiz-santiañez, R., Kraemer, B., Håberg, A. K., Jones, H. J., Pike, G. B., Stein, D. J., Stevens, A., Bralten, J., Vernooij, M. W., Harris, T. B., Filippi, I., Witte, A. V., Guadalupe, T., Wittfeld, K., Mosley, T. H., Becker, J. T., Doan, N. T., Hagenaars, S. P., Saba, Y., Cuellar-partida, G., Amin, N., Hilal, S., Nho, K., Mirza-schreiber, N., Arfanakis, K., Becker, D. M., Ames, D., Goldman, A. L., Lee, P. H., Boomsma, D. I., Lovestone, S., Giddaluru, S., Le Hellard, S., Mattheisen, M., Bohlken, M. M., Kasperaviciute, D., Schmaal, L., Lawrie, S. M., Agartz, I., Walton, E., Tordesillas-gutierrez, D., Davies, G. E., Shin, J., Ipser, J. C., Vinke, L. N., Hoogman, M., Jia, T., Burkhardt, R., Klein, M., Crivello, F., Janowitz, D., Carmichael, O., Haukvik, U. K., Aribisala, B. S., Schmidt, H., Strike, L. T., Cheng, C., Risacher, S. L., Pütz, B., Fleischman, D. A., Assareh, A. A., Mattay, V. S., Buckner, R. L., Mecocci, P., Dale, A. M., Cichon, S., Boks, M. P., Matarin, M., Penninx, B. W. J. H., Calhoun, V. D., Chakravarty, M. M., Marquand, A. F., Macare, C., Kharabian Masouleh, S., Oosterlaan, J., Amouyel, P., Hegenscheid, K., Rotter, J. I., Schork, A. J., Liewald, D. C. M., De Zubicaray, G. I., Wong, T. Y., Shen, L., Sämann, P. G., Brodaty, H., Roffman, J. L., De Geus, E. J. C., Tsolaki, M., Erk, S., Van Eijk, K. R., Cavalleri, G. L., Van Der Wee, N. J. A., Mcintosh, A. M., Gollub, R. L., Bulayeva, K. B., Bernard, M., Richards, J. S., Himali, J. J., Loeffler, M., Rommelse, N., Hoffmann, W., Westlye, L. T., Valdés Hernández, M. C., Hansell, N. K., Van Erp, T. G. M., Wolf, C., Kwok, J. B. J., Vellas, B., Heinz, A., Olde Loohuis, L. M., Delanty, N., Ho, B., Ching, C. R. K., Shumskaya, E., Singh, B., Hofman, A., Van Der Meer, D., Homuth, G., Psaty, B. M., Bastin, M. E., Montgomery, G. W., Foroud, T. M., Reppermund, S., Hottenga, J., Simmons, A., Meyer-lindenberg, A., Cahn, W., Whelan, C. D., Van Donkelaar, M. M. J., Yang, Q., Hosten, N., Green, R. C., Thalamuthu, A., Mohnke, S., Hulshoff Pol, H. E., Lin, H., Jack, C. R., Schofield, P. R., Mühleisen, T. W., Maillard, P., Potkin, S. G., Wen, W., Fletcher, E., Toga, A. W., Gruber, O., Huentelman, M., Davey Smith, G., Launer, L. J., Nyberg, L., Jönsson, E. G., Crespo-facorro, B., Koen, N., Greve, D. N., Uitterlinden, A. G., Weinberger, D. R., Steen, V. M., Fedko, I. O., Groenewold, N. A., Niessen, W. J., Toro, R., Tzourio, C., Longstreth, W. T., Ikram, M. K., Smoller, J. W., Van Tol, M., Sussmann, J. E., Paus, T., Lemaître, H., Schroeter, M. L., Mazoyer, B., Andreassen, O. A., Holsboer, F., Depondt, C., Veltman, D. J., Turner, J. A., Pausova, Z., Schumann, G., Van Rooij, D., Djurovic, S., Deary, I. J., Mcmahon, K. L., Müller-myhsok, B., Brouwer, R. M., Soininen, H., Pandolfo, M., Wassink, T. H., Cheung, J. W., Wolfers, T., Martinot, J., Zwiers, M. P., Nauck, M., Melle, I., Martin, N. G., Kanai, R., Westman, E., Kahn, R. S., Sisodiya, S. M., White, T., Saremi, A., Van Bokhoven, H., Brunner, H. G., Völzke, H., Wright, M. J., Van ‘t Ent, D., Nöthen, M. M., Ophoff, R. A., Buitelaar, J. K., Fernández, G., Sachdev, P. S., Rietschel, M., Van Haren, N. E. M., Fisher, S. E., Beiser, A. S., Francks, C., Saykin, A. J., Mather, K. A., Romanczuk-seiferth, N., Hartman, C. A., Destefano, A. L., Heslenfeld, D. J., Weiner, M. W., Walter, H., Hoekstra, P. J., Nyquist, P. A., Franke, B., Bennett, D. A., Grabe, H. J., Johnson, A. D., Chen, C., Van Duijn, C. M., Lopez, O. L., Fornage, M., Wardlaw, J. M., Schmidt, R., Decarli, C., De Jager, P. L., Villringer, A., Debette, S., Gudnason, V., Medland, S. E., Shulman, J. M., Thompson, P. M., Seshadri, S. & Ikram, M. A., 21 Oct 2019, In : Nature Genetics.

    Research output: Contribution to journalArticle

  69. Inspiring New Researchers in Stroke: The ESO Edinburgh Stroke Research Workshop

    Orav, K., Moullaali, T. J., Sandset, E. C., Doubal, F. & Whiteley, W., 15 Oct 2019, In : Stroke.

    Research output: Contribution to journalComment/debate

  70. Predicting the Evolution of White Matter Hyperintensities in Brain MRI using Generative Adversarial Networks and Irregularity Map

    Rachmadi, M., Valdes Hernandez, M., Makin, S., Wardlaw, J. & Komura, T., 10 Oct 2019, Medical Image Computing and Computer Assisted Intervention – MICCAI 2019. Shen, D., Liu, T., Peters, T. M., Staib, L. H., Essert, C., Zhou, S., Yap, P-T. & Khan, A. (eds.). Springer, p. 146–154 9 p. (Lecture Notes in Computer Science (LNCS); vol. 11766).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  71. Prehospital Transdermal Glyceryl Trinitrate for Ultra-Acute Intracerebral Hemorrhage: Data From the RIGHT-2 Trial

    Bath, P. M., Woodhouse, L. J., Krishnan, K., Appleton, J. P., Anderson, C. S., Berge, E., Cala, L., Dixon, M., England, T. J., Godolphin, P. J., Hepburn, T., Mair, G., Montgomery, A. A., Phillips, S. J., Potter, J., Price, C. I., Randall, M., Robinson, T. G., Roffe, C., Rothwell, P. M. & 7 others, Sandset, E. C., Sanossian, N., Saver, J. L., Siriwardena, A. N., Venables, G., Wardlaw, J. M. & Sprigg, N., 7 Oct 2019, In : Stroke.

    Research output: Contribution to journalArticle

  72. Mechanical thrombectomy in patients with acute ischemic stroke: A cost-effectiveness and value of implementation analysis

    Heggie, R., Wu, O., White, P., Ford, G. A., Wardlaw, J., Brown, M. M., Clifton, A. & Muir, K. W., 30 Sep 2019, In : International Journal of Stroke. p. 174749301987965

    Research output: Contribution to journalArticle

  73. Observer Agreement on Computed Tomography Perfusion Imaging in Acute Ischemic Stroke

    El-tawil, S., Mair, G., Huang, X., Sakka, E., Palmer, J., Ford, I., Kalra, L., Wardlaw, J. & Muir, K. W., 25 Sep 2019, In : Stroke.

    Research output: Contribution to journalArticle

  74. Special topic section: linkages among cerebrovascular, cardiovascular, and cognitive disorders: Preventing dementia by preventing stroke: The Berlin Manifesto

    Hachinski, V., Einhäupl, K., Ganten, D., Alladi, S., Brayne, C., Stephan, B. C. M., Sweeney, M. D., Zlokovic, B., Iturria-medina, Y., Iadecola, C., Nishimura, N., Schaffer, C. B., Whitehead, S. N., Black, S. E., Østergaard, L., Wardlaw, J., Greenberg, S., Friberg, L., Norrving, B., Rowe, B. & 6 others, Joanette, Y., Hacke, W., Kuller, L., Dichgans, M., Endres, M. & Khachaturian, Z. S., 22 Sep 2019, In : International Journal of Stroke. p. 174749301987191

    Research output: Contribution to journalArticle

  75. Brain peak width of skeletonised mean diffusivity (PSMD) and cognitive function in later life

    Deary, I., Ritchie, S. J., Muñoz Maniega, S., Cox, S., Valdes Hernandez, M., Luciano, M., Starr, J., Wardlaw, J. & Bastin, M., 26 Jul 2019, In : Frontiers in psychiatry. 10, 524.

    Research output: Contribution to journalArticle

  76. Preventing dementia by preventing stroke: The Berlin Manifesto

    Hachinski, V., Einhäupl, K., Ganten, D., Alladi, S., Brayne, C., Stephan, B. C. M., Sweeney, M. D., Zlokovic, B., Iturria-medina, Y., Iadecola, C., Nishimura, N., Schaffer, C. B., Whitehead, S. N., Black, S. E., Østergaard, L., Wardlaw, J., Greenberg, S., Friberg, L., Norrving, B., Rowe, B. & 6 others, Joanette, Y., Hacke, W., Kuller, L., Dichgans, M., Endres, M. & Khachaturian, Z. S., 18 Jul 2019, In : Alzheimer's & Dementia. 15, 7, p. 961-984

    Research output: Contribution to journalArticle

  77. Lowering blood pressure after acute intracerebral haemorrhage: protocol for a systematic review and meta-analysis using individual patient data from randomised controlled trials participating in the Blood Pressure in Acute Stroke Collaboration (BASC)

    Moullaali, T. J., Wang, X., Woodhouse, L. J., Law, Z. K., Delcourt, C., Sprigg, N., Krishnan, K., Robinson, T. G., Wardlaw, J. M., Al-shahi Salman, R., Berge, E., Sandset, E. C., Anderson, C. S. & Bath, P. M., 16 Jul 2019, In : BMJ Open. 9, 7, e030121.

    Research output: Contribution to journalArticle

  78. Structural neuroimaging differentiates vulnerability from disease manifestation in colombian families with Huntington’s disease

    C. Valdés Hernández, M., Abu‐hussain, J., Qiu, X., Priller, J., Parra Rodríguez, M., Pino, M., Báez, S. & Ibáñez, A., 5 Jul 2019, In : Brain and Behavior.

    Research output: Contribution to journalArticle

  79. Effects of Isosorbide Mononitrate and/or Cilostazol on Hematological Markers, Platelet Function, and Hemodynamics in Patients With Lacunar Ischaemic Stroke: Safety Data From the Lacunar Intervention-1 (LACI-1) Trial

    Appleton, J. P., Blair, G. W., Flaherty, K., Law, Z. K., May, J., Woodhouse, L. J., Doubal, F., Sprigg, N., Bath, P. M. & Wardlaw, J. M., 3 Jul 2019, In : Frontiers in Neurology. 10

    Research output: Contribution to journalArticle

  80. Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

    Al-Shahi Salman, R., Minks, D. P., Mitra, D., Rodrigues, M. A., Bhatnagar, P., du Plessis, J. C., Joshi, Y., Dennis, M. S., Murray, G. D., Newby, D. E., Sandercock, P. A. G., Sprigg, N., Stephen, J., Sudlow, C. L. M., Werring, D. J., Whiteley, W. N., Wardlaw, J. M., White, P. M. & RESTART collaboration, 1 Jul 2019, In : Lancet Neurology. 18, 7, p. 643-652 10 p.

    Research output: Contribution to journalArticle

  81. Cerebral microbleeds and stroke risk after ischaemic stroke or transient ischaemic attack: a pooled analysis of individual patient data from cohort studies

    Microbleeds International Collaborative Network, Jul 2019, In : Lancet Neurology. 18, 7, p. 653-665 13 p.

    Research output: Contribution to journalArticle

  82. Effects of antiplatelet therapy after stroke due to intracerebral haemorrhage (RESTART): a randomised, open-label trial

    RESTART collaboration & Wardlaw, J., 29 Jun 2019, In : The Lancet. 393, 10191, p. 2613-2623 11 p.

    Research output: Contribution to journalArticle

  83. Reaction time variability and brain white matter integrity

    Booth, T., Dykiert, D., Corley, J., Gow, A., Morrison, Z., Munoz-Maniega, S., Royle, N., Valdes Hernandez, M., Starr, J., Penke, L., Bastin, M., Wardlaw, J. & Deary, I., 28 Jun 2019, In : Neuropsychology. 33, 5, p. 642-657

    Research output: Contribution to journalArticle

  84. Dilated Saliency U-Net for White Matter Hyperintensities Segmentation Using Irregularity Age Map

    Jeong, Y., Rachmadi, M. F., Valdés-Hernández, M. D. C. & Komura, T., 27 Jun 2019, In : Frontiers in Aging Neuroscience. 11

    Research output: Contribution to journalArticle

  85. Factors associated with potentially serious incidental findings and with serious final diagnoses on multi-modal imaging in the UK Biobank Imaging Study: a prospective cohort study

    Sudlow, C., Gibson, L., Nolan, J., Littlejohns, T. J., Mathieu, E., Garratt, S., Doherty, N., Petersen, S. E., Harvey, N. C. W., Sellors, J., Allen, N. E., Wardlaw, J. & Jackson, C., 17 Jun 2019, In : PLoS ONE. 16, 6, e0218267.

    Research output: Contribution to journalArticle

  86. Evaluation of Enhanced Learning Techniques for Segmenting Ischaemic Stroke Lesions in Brain Magnetic Resonance Perfusion Images Using a Convolutional Neural Network Scheme

    Pérez Malla, C. U., Valdés Hernández, M. D. C., Rachmadi, M. F. & Komura, T., 29 May 2019, In : Frontiers in Neuroinformatics. 13, 33.

    Research output: Contribution to journalArticle

  87. Stability of estimated premorbid cognitive ability over time after minor stroke and its relationship with post-stroke cognitive ability

    McHutchison, C. A., Chappell, F. M., Makin, S., Shuler, K., Wardlaw, J. M. & Cvoro, V., 22 May 2019, In : Brain Sciences. 9, 5, p. 1-15 117.

    Research output: Contribution to journalArticle

  88. Cortical thickness, white matter hyperintensities, and cognition after stroke

    Dickie, D. A., Gardner, K., Wagener, A., Wyss, A., Arba, F., Wardlaw, J. M. & Dawson, J., 14 May 2019, In : International Journal of Stroke. p. 174749301985129

    Research output: Contribution to journalArticle

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