Edinburgh Research Explorer

Small Vessel Disease Research

Organisational unit: Research Group

  1. 2018
  2. Baseline characteristics of the 1149 patients recruited into the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) randomized controlled trial

    Bath, P. M., Scutt, P., Appleton, J. P., Dixon, M., Woodhouse, L. J., Wardlaw, J. M. & Sprigg, N., 26 Nov 2018, In: International Journal of Stroke. p. 1747493018816451

    Research output: Contribution to journalArticlepeer-review

  3. Central masked adjudication of stroke diagnosis at trial entry offered no advantage over diagnosis by local clinicians: Secondary analysis and simulation

    Godolphin, P. J., Hepburn, T., Sprigg, N., Walker, L., Berge, E., Collins, R., Gommans, J., Ntaios, G., Pocock, S., Prasad, K., Wardlaw, J. M., Bath, P. M. & Montgomery, A. A., 10 Nov 2018, In: Contemporary clinical trials communications. 12, p. 176-181

    Research output: Contribution to journalArticlepeer-review

  4. Secondary prevention of Alzheimer's dementia: neuroimaging contributions

    Ten Kate, M., Ingala, S., Schwarz, A. J., Fox, N. C., Chételat, G., van Berckel, B. N. M., Ewers, M., Foley, C., Gispert, J. D., Hill, D., Irizarry, M. C., Lammertsma, A. A., Molinuevo, J. L., Ritchie, C., Scheltens, P., Schmidt, M. E., Visser, P. J., Waldman, A., Wardlaw, J., Haller, S. & 1 others, Barkhof, F., 30 Oct 2018, In: Alzheimer's research & therapy. 10, 1, p. 112

    Research output: Contribution to journalReview articlepeer-review

  5. Action Plan for Stroke in Europe 2018–2030

    Norrving, B., Barrick, J., Davalos, A., Dichgans, M., Cordonnier, C., Guekht, A., Kutluk, K., Mikulik, R., Wardlaw, J., Richard, E., Nabavi, D., Molina, C., Bath, P. M., Stibrant Sunnerhagen, K., Rudd, A., Drummond, A., Planas, A. & Caso, V., 29 Oct 2018, In: European Stroke Journal. p. 239698731880871

    Research output: Contribution to journalArticlepeer-review

  6. Effect of IV alteplase on the ischemic brain lesion at 24-48 hours after ischemic stroke

    Mair, G., von Kummer, R., Morris, Z., von Heijne, A., Bradey, N., Cala, L., Peeters, A., Farrall, A., Adami, A., Potter, G., Sandercock, P., Lindley, R. I., Wardlaw, J. & IST-3 Collaborative Group, 26 Oct 2018, In: Neurology. 91, 22, p. e2067-e2077

    Research output: Contribution to journalArticlepeer-review

  7. Percutaneous vascular interventions versus intravenous thrombolytic treatment for acute ischaemic stroke

    Lindekleiv, H., Berge, E., Bruins Slot, K. M. & Wardlaw, J. M., 26 Oct 2018, In: The Cochrane Library.

    Research output: Contribution to journalReview articlepeer-review

  8. Investigating pedestrian navigation in indoor open space environments using big data

    Lovreglio, R., Charitha, D., Xiang, S. & Ballerini, L., Oct 2018, In: Applied mathematical modelling. 62, p. 499-509

    Research output: Contribution to journalArticlepeer-review

  9. The association between carotid atheroma and cerebral cortex structure at age 73

    Alhusaini, S., Karama, S., Nguyen, T-V., Thiel, A., Bernhardt, B., Cox, S., Corley, J., Taylor, A., Evans, A. C., Starr, J., Bastin, M., Wardlaw, J., Deary, I. & Ducharme, S., Oct 2018, In: Annals of Neurology. 84, 4, p. 576-587

    Research output: Contribution to journalArticlepeer-review

  10. Genome-wide association study of 23,500 individuals identifies 7 loci associated with brain ventricular volume

    Vojinovic, D., Adams, H. H., Jian, X., Yang, Q., Smith, A. V., Bis, J. C., Teumer, A., Scholz, M., Armstrong, N. J., Hofer, E., Saba, Y., Luciano, M., Bernard, M., Trompet, S., Yang, J., Gillespie, N. A., Van Der Lee, S. J., Neumann, A., Ahmad, S., Andreassen, O. A. & 71 others, Ames, D., Amin, N., Arfanakis, K., Bastin, M. E., Becker, D. M., Beiser, A. S., Beyer, F., Brodaty, H., Bryan, R. N., Bülow, R., Dale, A. M., De Jager, P. L., Deary, I. J., Decarli, C., Fleischman, D. A., Gottesman, R. F., Van Der Grond, J., Gudnason, V., Harris, T. B., Homuth, G., Knopman, D. S., Kwok, J. B., Lewis, C. E., Li, S., Loeffler, M., Lopez, O. L., Maillard, P., El Marroun, H., Mather, K. A., Mosley, T. H., Muetzel, R. L., Nauck, M., Nyquist, P. A., Panizzon, M. S., Pausova, Z., Psaty, B. M., Rice, K., Rotter, J. I., Royle, N., Satizabal, C. L., Schmidt, R., Schofield, P. R., Schreiner, P. J., Sidney, S., Stott, D. J., Thalamuthu, A., Uitterlinden, A. G., Valdés Hernández, M. C., Vernooij, M. W., Wen, W., White, T., Witte, A. V., Wittfeld, K., Wright, M. J., Yanek, L. R., Tiemeier, H., Kremen, W. S., Bennett, D. A., Jukema, J. W., Paus, T., Wardlaw, J. M., Schmidt, H., Sachdev, P. S., Villringer, A., Grabe, H. J., Longstreth, W. T., Van Duijn, C. M., Launer, L. J., Seshadri, S., Ikram, M. A. & Fornage, M., 26 Sep 2018, In: Nature Communications. 9, 1, 3945.

    Research output: Contribution to journalArticlepeer-review

  11. Automatic Irregular Texture Detection in Brain MRI without Human Supervision

    Rachmadi, M., Valdes Hernandez, M. & Komura, T., 13 Sep 2018, Medical Image Computing and Computer Assisted Intervention – MICCAI 2018. Granada, Spain: Springer, Cham, p. 506-513 8 p. (Lecture Notes in Computer Science; vol. 11072)(Image Processing, Computer Vision, Pattern Recognition, and Graphics; vol. 11072).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  12. Transfer Learning for Task Adaptation of Brain Lesion Assessment and Prediction of Brain Abnormalities Progression/Regression Using Irregularity Age Map in Brain MRI

    Rachmadi, M., Valdes Hernandez, M. & Komura, T., 13 Sep 2018, PRIME: International Workshop on PRedictive Intelligence In MEdicine. Granada, Spain: Springer, Cham, p. 85-93 9 p. (Lecture Notes in Computer Science; vol. 11121)(Image Processing, Computer Vision, Pattern Recognition, and Graphics; vol. 11121).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  13. Reproducibility of Transcranial Doppler ultrasound in the middle cerebral artery

    Kaczynski, J., Home, R., Shields, K., Walters, M., Whiteley, W., Wardlaw, J. & Newby, D. E., 11 Sep 2018, In: Cardiovascular ultrasound. 16, 1, p. 15

    Research output: Contribution to journalArticlepeer-review

  14. Considerations on accuracy, pattern and possible underlying factors of brain microbleeds progression on older adults with absence or mild presence of vascular pathology

    Alzheimer’s Disease Neuroimaging Initiative, 1 Sep 2018, In: Journal of International Medical Research. 21 p.

    Research output: Contribution to journalArticlepeer-review

  15. The key challenges of discussing end-of life stroke care with patients and families: a mixed-methods electronic survey of hospital and community healthcare professionals

    Doubal, F., Cowey, E., Bailey, F., Murray, S., Borthwick, S., Somerville, M., Lerpiniere, C., Reid, L., Boyd, K., Hynd, G. & Mead, G., 1 Sep 2018, In: Journal of the Royal College of Physicians of Edinburgh. 48, 3, p. 217-224

    Research output: Contribution to journalArticlepeer-review

  16. Longitudinal serum S100β and brain ageing in the Lothian Birth Cohort 1936

    Cox, S., Allerhand, M., Ritchie, S. J., Muñoz Maniega, S., Valdes Hernandez, M., Harris, S., Dickie, D. A., Anblagan, D., Aribisala, B., Morris, Z., Sherwood, R., Abbott, N. J., Starr, J., Bastin, M., Wardlaw, J. & Deary, I., Sep 2018, In: Neurobiology of Aging. 69, p. 274-282

    Research output: Contribution to journalArticlepeer-review

  17. Do 2-year changes in superior frontal gyrus and global brain atrophy affect cognition?

    The Alzheimer’s Disease Neuroimaging Initiative, 30 Aug 2018, In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. 10

    Research output: Contribution to journalArticlepeer-review

  18. Machine learning of neuroimaging for assisted diagnosis of cognitive impairment and dementia: A systematic review

    Pellegrini, E., Ballerini, L., Hernandez, M. D. C. V., Chappell, F. M., González-castro, V., Anblagan, D., Danso, S., Maniega, S. M., Job, D., Pernet, C., Mair, G., Macgillivray, T., Trucco, E. & Wardlaw, J., 11 Aug 2018, In: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring.

    Research output: Contribution to journalReview articlepeer-review

  19. Impact of detecting potentially serious incidental findings during multi-modal imaging: [version 3; peer review: 2 approved, 1 approved with reservations]

    Gibson, L. M., Littlejohns, T. J., Adamska, L., Garratt, S., Doherty, N., Wardlaw, J. M., Maskell, G., Parker, M., Brownsword, R., Matthews, P. M., Collins, R., Allen, N. E., Sellors, J. & Sudlow, C., 2 Aug 2018, In: Wellcome Open Research . 2, p. 114

    Research output: Contribution to journalArticlepeer-review

  20. Using orthogonal locality preserving projections to find dominant features for classifying retinal blood vessels

    Relan, D., Ballerini, L., Trucco, E. & MacGillivray, T., 1 Aug 2018, In: Multimedia Tools and Applications. p. 1-21

    Research output: Contribution to journalArticlepeer-review

  21. Widespread associations between trait conscientiousness and thickness of brain cortical regions

    Lewis, G. J., Dickie, D. A., Cox, S. R., Karama, S., Evans, A. C., Starr, J. M., Bastin, M. E., Wardlaw, J. M. & Deary, I. J., 1 Aug 2018, In: NeuroImage. 176, p. 22-28

    Research output: Contribution to journalArticlepeer-review

  22. Exome chip analysis identifies low-frequency and rare variants in MRPL38 for white matter hyperintensities on brain MRI

    Jian, X., Satizabal, C. L., Smith, A. V., Wittfield, K., Bis, J. C., Smith, J., Hsu, F-C., Nho, K., Hofer, E., Hagenaars, S., Nyquist, P. A., Mishra, A., Adams, H. H. H., Li, S., Teumer, A., Zhao, W., Freedman, B. I., Saba, Y., Yanek, L. R., Chauhan, G. & 58 others, Van Buchem, M. A., Cushman, M., Royle, N., Bryan, R. N., Niessen, W. J., Windham, B. G., DeStefano, A. L., Habes, M., Heckbert, S. R., Palmer, N. D., Lewis, C. E., Eiriksdottir, G., Maillard, P., Mathias, R. A., Homuth, G., Valdes Hernandez, M., Divers, J., Beiser, A. S., Langner, S., Rice, K. M., Bastin, M., Yang, Q., Maldjan, J. A., Starr, J., Sidney, S. S., Risacher, S. L., Uitterlinden, A. G., Gudnason, V., Nauck, M., Rotter, J. I., Schreiner, P. J., Boerwinkle, E., van Duijn, C., Mazoyer, B., von Sarnowski, B., Gottesman, R. F., Levy, D., Sigurdsson, S., Vernooij, M. W., Turner, S. T., Schmidt, R., Wardlaw, J., Psaty, B. M., Mosley, T. H., DeCarli, C., Saykin, A. J., Bowden, D. W., Becker, D. M., Deary, I., Schmidt, H., Kardia, S. L. R., Ikram, M. A., Debette, S., Grabe, H. J., Longstreth, W. T., Seshadri, S., Launer, L. J. & Fornage, M., 12 Jul 2018, In: Stroke. 49, 8, p. 1812-1819

    Research output: Contribution to journalArticlepeer-review

  23. The Glymphatic System and Waste Clearance with Brain Aging: A Review

    Benveniste, H., Liu, X., Koundal, S., Sanggaard, S., Lee, H. & Wardlaw, J., 11 Jul 2018, In: Gerontology. p. 1-14 14 p.

    Research output: Contribution to journalReview articlepeer-review

  24. Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

    Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F. J., Fornage, M., Seshadri, S., Atanur, S. S., Dominiczak, A. F., Smith, C., Wardlaw, J. M. & Williams, A., 4 Jul 2018, In: Science Translational Medicine. 10, 448, 12 p., eaam9507.

    Research output: Contribution to journalArticlepeer-review

  25. The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke

    Loos, C. M. J., McHutchison, C., Cvoro, V., Makin, S., Staals, J., Chappell, F., Dennis, M., van Oostenbrugge, R. J. & Wardlaw, J., 1 Jul 2018, In: International Journal of Stroke. 13, 5, p. 518-524

    Research output: Contribution to journalArticlepeer-review

  26. William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable

    Wardlaw, J. M., 12 Jun 2018, In: Stroke. 49, 7, p. 1770-1775

    Research output: Contribution to journalArticlepeer-review

  27. Neurological Disease in Lupus: Toward a Personalized Medicine Approach

    Mcglasson, S., Wiseman, S., Wardlaw, J., Dhaun, N. & Hunt, D. P. J., 6 Jun 2018, In: Frontiers in Immunology. 9

    Research output: Contribution to journalReview articlepeer-review

  28. A large margin algorithm for automated segmentation of white matter hyperintensity

    Qin, C., Guerrero, R., Bowles, C., Chen, L., Dickie, D. A., Valdes-Hernandez, M. D. C., Wardlaw, J. & Rueckert, D., 31 May 2018, In: Pattern Recognition. 77, p. 150-159 10 p.

    Research output: Contribution to journalArticlepeer-review

  29. Brain age predicts mortality

    Cole, J. H., Ritchie, S. J., Bastin, M. E., Valdés Hernández, M. C., Muñoz Maniega, S., Royle, N., Corley, J., Pattie, A., Harris, S. E., Zhang, Q., Wray, N. R., Redmond, P., Marioni, R. E., Starr, J. M., Cox, S. R., Wardlaw, J. M., Sharp, D. J. & Deary, I. J., 31 May 2018, In: Molecular Psychiatry. 23, p. 1385-1392 8 p.

    Research output: Contribution to journalArticlepeer-review

  30. Characterisation of tissue-type metabolic content in Secondary Progressive Multiple Sclerosis: a Magnetic Resonance Spectroscopic Imaging study

    MS-SMART Trialists, 30 May 2018, In: Journal of Neurology.

    Research output: Contribution to journalArticlepeer-review

  31. Mapping cortical brain asymmetry in 17,141 healthy individuals worldwide via the ENIGMA Consortium

    Kong, X-Z., Mathias, S. R., Guadalupe, T., Glahn, D. C., Franke, B., Crivello, F., Tzourio-Mazoyer, N., Fisher, S. E., Thompson, P. M., Francks, C., ENIGMA Laterality Working Group, Valdes Hernandez, M., Wardlaw, J., Harris, M. & Luciano, M., 29 May 2018, In: Proceedings of the National Academy of Sciences. 115, 22, p. E5154-E5163

    Research output: Contribution to journalArticlepeer-review

  32. Fourth European stroke science workshop

    Debette, S., Strbian, D., Wardlaw, J., Van Der Worp, H., Rinkel, G., Caso, V., Dichgans, M., Tournier-lasserve, E., Grefkes, C., Kelly, P., Muir, K., Berge, E., Trégouët, D., Roffe, C., Brainin, M., Beck, J., Steiner, T., De Lau, L., Jouvent, E., Veltkamp, R. & 26 others, Baron, J., Nedeltchev, K., Bath, P., Quinn, T., Richard, E., Ziemann, U., Liesz, A., Ntaios, G., Iadecola, C., Lees, K., Christensen, H. K., Van Veluw, S., Endres, M., Anderson, C., Molina, C., Düring, M., Dufouil, C., Ostergaard, L., Samani, N., Fischer, U., De Leeuw, F., Norrving, B., Biessels, G., Cordonnier, C., Mas, J. & Mattle, H., 24 May 2018, In: European Stroke Journal. 3, 3, p. 206-219

    Research output: Contribution to journalComment/debatepeer-review

  33. Rapid automated quantification of cerebral leukoaraiosis on CT images: A Multicenter Validation Study

    Chen, L., Carlton Jones, A. L., Mair, G., Patel, R., Gontsarova, A., Ganesalingam, J., Math, N., Dawson, A., Aweid, B., Cohen, D., Mehta, A., Wardlaw, J., Rueckert, D., Bentley, P. & IST-3 Collaborative Group, 15 May 2018, In: Radiology. 288, 2, p. 573–581 9 p.

    Research output: Contribution to journalArticlepeer-review

  34. Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors

    Pinter, D., Gattringer, T., Enzinger, C., Seifert-Held, T., Kneihsl, M., Fandler, S., Pichler, A., Barro, C., Eppinger, S., Pirpamer, L., Bachmaier, G., Ropele, S., Wardlaw, J., Kuhle, J., Khalil, M. & Fazekas, F., 8 May 2018, In: Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticlepeer-review

  35. Voxel-Based Irregularity Age Map (IAM) for Brain’s White Matter Hyperintensities in MRI

    Rachmadi, M., Valdes Hernandez, M., Komura, T. & Alzheimer’s Disease Neuroimaging Initiative, 7 May 2018, 2017 International Conference on Advanced Computer Science and Information Systems (ICACSIS). Institute of Electrical and Electronics Engineers (IEEE)

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  36. Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus

    Wiseman, S., Bastin, M., Amft, E., Belch, J. F. F., Ralston, S. & Wardlaw, J., 3 May 2018, In: Lupus.

    Research output: Contribution to journalArticlepeer-review

  37. Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3

    Sandset, E. C., Sanossian, N., Woodhouse, L. J., Anderson, C., Berge, E., Lees, K. R., Potter, J. F., Robinson, T. G., Sprigg, N., Wardlaw, J. M., Bath, P. M. & Blood pressure in Acute Stroke Collaboration Investigators, 3 May 2018, In: International Journal of Stroke. p. 1747493018772733

    Research output: Contribution to journalArticlepeer-review

  38. Understanding the role of the perivascular space in cerebral small vessel disease

    Brown, R., Benveniste, H., Black, S. E., Charpak, S., Dichgans, M., Joutel, A., Nedergaard, M., Smith, K. J., Zlokovic, B. V. & Wardlaw, J. M., 2 May 2018, In: Cardiovascular Research.

    Research output: Contribution to journalArticlepeer-review

  39. 'Small vessels, dementia and chronic diseases -molecular mechanisms and pathophysiology' Workshop proceedings

    Horsburgh, K., Wardlaw, J., Van Agtmael, T., Allan, S., Ashford, M., Bath, P. M., Brown, R., Berwick, J., Cader, M. Z., Carare, R. O., Davies, J. B., Duncombe, J., Farr, T. D., Fowler, J., Goense, J., Granata, A., Hall, C., Hainsworth, A., Harvey, A., Hawkes, C. & 26 others, Joutel, A., Kalaria, R. N., Kehoe, P. G., Lawrence, C. B., Lockhart, A., Love, S., MacLeod, M., Macrae, M., Markus, H. S., McCabe, C., McColl, B., Meakin, P. J., Miller, A. A., Nedergaard, M., O'Sullivan, M., Quinn, T., Rajani, R., Saksida, L. M., Smith, C., Smith, K. J., Touyz, R., Trueman, R., Wang, T., Williams, A., Williams, S. & Work, L. M., 30 Apr 2018, In: Clinical science. 132, 8, p. 851-868

    Research output: Contribution to journalReview articlepeer-review

  40. The Brain Health Index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury

    Dickie, D. A., Valdes Hernandez, M., Makin, S., Staals, J., Wiseman, S., Bastin, M. & Wardlaw, J., 19 Apr 2018, In: International Journal of Stroke.

    Research output: Contribution to journalArticlepeer-review

  41. Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease

    Bailey, E. L., Mcbride, M. W., Mcclure, J. D., Beattie, W., Graham, D., Dominiczak, A. F., Smith, C. & Wardlaw, J., 9 Apr 2018, In: Clinical science.

    Research output: Contribution to journalArticlepeer-review

  42. Direct Estimation of Pharmacokinetic Parameters from DCE-MRI using Deep CNN with Forward Physical Model Loss

    Ulas, C., Tetteh, G., Thrippleton, M. J., Armitage, P. A., Makin, S. D., Wardlaw, J. M., Davies, M. E. & Menze, B. H., 8 Apr 2018.

    Research output: Contribution to conferencePaperpeer-review

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