Edinburgh Research Explorer

Small Vessel Disease Research

Organisational unit: Research Group

  1. 2016
  2. Endovascular therapy for acute ischaemic stroke: the Pragmatic Ischaemic Stroke Thrombectomy Evaluation (PISTE) randomised, controlled trial

    Muir, K. W., Ford, G. A., Messow, C-M., Ford, I., Murray, A., Clifton, A., Brown, M. M., Madigan, J., Lenthall, R., Robertson, F., Dixit, A., Cloud, G. C., Wardlaw, J., Freeman, J., White, P. & PISTE Investigators, 18 Oct 2016, In: Journal of Neurology, Neurosurgery & Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  3. Human subcortical brain asymmetries in 15,847 people worldwide reveal effects of age and sex

    Guadalupe, T., Mathias, S. R., vanErp, T. G. M., Whelan, C. D., Zwiers, M. P., Abe, Y., Abramovic, L., Agartz, I., Andreassen, O. A., Arias-Vásquez, A., Aribisala, B. S., Armstrong, N. J., Arolt, V., Artiges, E., Ayesa-Arriola, R., Baboyan, V. G., Banaschewski, T., Barker, G., Bastin, M. E., Baune, B. T. & 141 others, Blangero, J., Bokde, A. L. W., Boedhoe, P. S. W., Bose, A., Brem, S., Brodaty, H., Bromberg, U., Brooks, S., Büchel, C., Buitelaar, J., Calhoun, V. D., Cannon, D. M., Cattrell, A., Cheng, Y., Conrod, P. J., Conzelmann, A., Corvin, A., Crespo-Facorro, B., Crivello, F., Dannlowski, U., de Zubicaray, G. I., de Zwarte, S. M. C., Deary, I. J., Desrivières, S., Doan, N. T., Donohoe, G., Dørum, E. S., Ehrlich, S., Espeseth, T., Fernández, G., Flor, H., Fouche, J-P., Frouin, V., Fukunaga, M., Gallinat, J., Garavan, H., Gill, M., Suarez, A. G., Gowland, P., Grabe, H. J., Grotegerd, D., Gruber, O., Hagenaars, S., Hashimoto, R., Hauser, T. U., Heinz, A., Hibar, D. P., Hoekstra, P. J., Hoogman, M., Howells, F. M., Hu, H., Hulshoff Pol, H. E., Huyser, C., Ittermann, B., Jahanshad, N., Jönsson, E. G., Jurk, S., Kahn, R. S., Kelly, S., Kraemer, B., Kugel, H., Kwon, J. S., Lemaitre, H., Lesch, K-P., Lochner, C., Luciano, M., Marquand, A. F., Martin, N. G., Martínez-Zalacaín, I., Martinot, J-L., Mataix-Cols, D., Mather, K., McDonald, C., McMahon, K. L., Medland, S. E., Menchón, J. M., Morris, D. W., Mothersill, O., Maniega, S. M., Mwangi, B., Nakamae, T., Nakao, T., Narayanaswaamy, J. C., Nees, F., Nordvik, J. E., Onnink, A. M. H., Opel, N., Ophoff, R., Paillère Martinot, M-L., Papadopoulos Orfanos, D., Pauli, P., Paus, T., Poustka, L., Reddy, J. Y., Renteria, M. E., Roiz-Santiáñez, R., Roos, A., Royle, N. A., Sachdev, P., Sánchez-Juan, P., Schmaal, L., Schumann, G., Shumskaya, E., Smolka, M. N., Soares, J. C., Soriano-Mas, C., Stein, D. J., Strike, L. T., Toro, R., Turner, J. A., Tzourio-Mazoyer, N., Uhlmann, A., Hernández, M. V., van den Heuvel, O. A., van der Meer, D., van Haren, N. E. M., Veltman, D. J., Venkatasubramanian, G., Vetter, N. C., Vuletic, D., Walitza, S., Walter, H., Walton, E., Wang, Z., Wardlaw, J., Wen, W., Westlye, L. T., Whelan, R., Wittfeld, K., Wolfers, T., Wright, M. J., Xu, J., Xu, X., Yun, J-Y., Zhao, J., Franke, B., Thompson, P. M., Glahn, D. C., Mazoyer, B., Fisher, S. E. & Francks, C., 13 Oct 2016, In: Brain imaging and behavior.

    Research output: Contribution to journalArticlepeer-review

  4. Cognitive reserve moderates long-term cognitive and functional outcome in cerebral small vessel disease

    Jokinen, H., Melkas, S., Madureira, S., Verdelho, A., Ferro, J. M., Fazekas, F., Schmidt, R., Scheltens, P., Barkhof, F., Wardlaw, J., Inzitari, D., Pantoni, L. & Erkinjuntti, T., 7 Oct 2016, In: Journal of Neurology, Neurosurgery & Psychiatry.

    Research output: Contribution to journalArticlepeer-review

  5. Associations between education and brain structure at age 73 years, adjusted for age 11 IQ

    Cox, S., Dickie, D. A., Ritchie, S. J., Karama, S., Pattie, A., Royle, N., Corley, J., Aribisala, B., Valdes Hernandez, M. C., Muñoz Maniega, S., Starr, J., Bastin, M., Evans, A. C., Wardlaw, J. & Deary, I., Oct 2016, In: Neurology. 87, 17, p. 1820-1826 7 p.

    Research output: Contribution to journalArticlepeer-review

  6. Update on cerebral small vessel disease – a dynamic, whole-brain disease

    Shi, Y. & Wardlaw, J., 30 Sep 2016, In: Stroke and Vascular Neurology.

    Research output: Contribution to journalArticlepeer-review

  7. Pseudo-Healthy Image Synthesis for White Matter Lesion Segmentation

    Bowles, C., Qin, C., Ledig, C., Moreno, R. G., Gunn, R., Hammers, A., Sakka, E., Dickie, D. A., Valdes Hernandez, M., Royle, N., Wardlaw, J., Rhodius-Meester, H., Tijms, B., Lemstra, A., van der Flier, W., Barkhof, F., Scheltens, P. & Rueckert, D., 23 Sep 2016, Simulation and Synthesis in Medical Imaging. SpringerLink, Vol. 9968. p. 87-96 (Lecture Notes in Computer Science).

    Research output: Chapter in Book/Report/Conference proceedingConference contribution

  8. Small vessels, dementia and chronic diseases – molecular mechanisms and pathophysiology

    Wardlaw, J. & Horsburgh, K., 22 Sep 2016, In: Clinical science.

    Research output: Contribution to journalEditorialpeer-review

  9. Early life characteristics and late life burden of cerebral small vessel disease in the Lothian Birth Cohort 1936

    Field, T. S., Doubal, F., Johnson, W., Backhouse, E., McHutchison, C., Cox, S., Corley, J., Pattie, A., Gow, A., Shenkin, S., Cvoro, V., Morris, Z., Staals, J., Bastin, M., Deary, I. & Wardlaw, J., 19 Sep 2016, In: Aging. 8, 9, p. 2039-2061

    Research output: Contribution to journalArticlepeer-review

  10. Multicenter Evaluation of Geometric Accuracy of MRI Protocols Used in Experimental Stroke

    Milidonis, X., Lennen, R. J., Jansen, M., Mueller, S., Boehm-Sturm, P., Holmes, W. M., Sena, E., MacLeod, M. & Marshall, I., 7 Sep 2016, In: PLoS ONE.

    Research output: Contribution to journalArticlepeer-review

  11. Effects of alteplase on survival after ischaemic stroke (IST-3): 3 year follow-up of a randomised, controlled, open-label trial

    Berge, E., Cohen, G., Roaldsen, M. B., Lundström, E., Isaksson, E., Rudberg, A-S., Slot, K. B., Forbes, J., Smith, J., Drever, J., Wardlaw, J. M., Lindley, R. I., Sandercock, P. A. G., Whiteley, W. N. & IST-3 collaborative group, 1 Sep 2016, In: Lancet Neurology. 15, 10, p. 1028-1034 7 p.

    Research output: Contribution to journalArticlepeer-review

  12. Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack

    Arba, F., Quinn, T. J., Hankey, G. J., Lees, K. R., Wardlaw, J., Ali, M. & Inzitari, D., 19 Aug 2016, In: International Journal of Stroke.

    Research output: Contribution to journalArticlepeer-review

  13. Effects of alteplase for acute stroke on the distribution of functional outcomes: a pooled analysis of nine trials

    Lees, K. R., Emberson, J., Blackwell, L., Bluhmki, E., Davis, S., Donnan, G. A., Grotta, J. C., Kaste, M., von Kummer, R., Lansberg, M. G., Lindley, R., Lyden, P., Murray, G., Sandercock, P., Toni, D., Toyoda, K., Wardlaw, J., Whiteley, W., Baigent, C., Hacke, W. & 1 others, Howard, G., 9 Aug 2016, In: Stroke.

    Research output: Contribution to journalArticlepeer-review

  14. Cerebral blood flow in small vessel disease: a systematic review and meta-analysis

    Shi, Y., Thrippleton, M., Makin, S., Marshall, I., Geerlings, M. I., de Craen, A. J. M., Van Buchem, M. A. & Wardlaw, J., 5 Aug 2016, In: Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticlepeer-review

  15. Risk of intracerebral haemorrhage with alteplase after acute ischaemic stroke: a secondary analysis of an individual patient data meta-analysis

    for the Stroke Thrombolysis Trialists' Collaborative Group, 1 Aug 2016, In: Lancet Neurology. 15, 9, p. 925-933 9 p.

    Research output: Contribution to journalArticlepeer-review

  16. Brain white matter structure and information processing speed in healthy older age

    Kuznetsova, K., Muñoz Maniega, S., Ritchie, S. J., Cox, S. R., Storkey, A. J., Starr, J. M., Wardlaw, J. M., Deary, I. J. & Bastin, M. E., 31 Jul 2016, In: Brain Structure and Function. 221, 6, p. 3223-3235

    Research output: Contribution to journalArticlepeer-review

  17. Application of the ordered logit model to optimising Frangi filter parameters for segmentation of perivascular spaces

    Ballerini, L., Lovreglio, R., Valdes Hernandez, M., Gonzalez-Castro, V., Muñoz Maniega, S., Pellegrini, E., Bastin, M., Deary, I. & Wardlaw, J., 25 Jul 2016, In: Procedia Computer Science. p. 61-67

    Research output: Contribution to journalArticlepeer-review

  18. Automatic Generation of Synthetic Retinal Fundus Images: Vascular Network

    Bonaldi, L., Menti, E., Ballerini, L., Ruggeri, A. & Trucco, E., 25 Jul 2016, In: Procedia Computer Science. p. 54-60

    Research output: Contribution to journalArticlepeer-review

  19. Texture-based classification for the automatic rating of the perivascular spaces in brain MRI

    Gonzalez-Castro, V., Valdes Hernandez, M., Armitage, P. & Wardlaw, J., 25 Jul 2016, In: Procedia Computer Science. 90, p. 9-14

    Research output: Contribution to journalArticlepeer-review

  20. Automatic rating of perivascular spaces in brain MRI using bag of visual words

    Gonzalez-Castro, V., Valdes Hernandez, M., Armitage, P. & Wardlaw, J., 1 Jul 2016, Image Analysis and Recognition. SpringerLink, Vol. 9730. (Lecture Notes in Computer Science).

    Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

  21. Do white matter hyperintensities mediate the association between brain iron deposition and cognitive abilities in older people?

    Valdes Hernandez, M., Allerhand, M., Glatz, A., Clayson, L., Munoz-Maniega, S., Gow, A., Royle, N., Bastin, M., Starr, J., Deary, I. & Wardlaw, J., Jul 2016, In: European Journal of Neurology. 23, p. 1202-1209

    Research output: Contribution to journalArticlepeer-review

  22. Leveraging Multiscale Hessian-based Enhancement with a Novel Exudate Inpainting Technique for Retinal Vessel Segmentation

    Annunziata, R., Garzelli, A., Ballerini, L., Mecocci, A. & Trucco, E., Jul 2016, In: IEEE Journal of Biomedical and Health Informatics. 20, 4, p. 1129-1138

    Research output: Contribution to journalArticlepeer-review

  23. Automatic Generation of Synthetic Retinal Fundus Images: Vascular Network

    Bonaldi, L., Menti, E., Ballerini, L., Ruggeri, A. & Trucco, E., 17 Jun 2016.

    Research output: Contribution to conferencePosterpeer-review

  24. 3D shape analysis of the brain's third ventricle using a midplane encoded symmetric template model

    Kim, J., Valdes Hernandez, M., Royle, N., Muñoz Maniega, S., Aribisala, B., Gow, A., Bastin, M., Deary, I., Wardlaw, J. & Park, J., Jun 2016, In: Computer methods and programs in biomedicine. 129, p. 51-62

    Research output: Contribution to journalArticlepeer-review

  25. Vascular risk factors and progression of white matter hyperintensities in the Lothian Birth Cohort 1936

    Dickie, D. A., Ritchie, S. J., Cox, S., Sakka, E., Royle, N., Aribisala, B., Valdes Hernandez, M., Muñoz Maniega, S., Pattie, A., Corley, J., Starr, J., Bastin, M., Deary, I. & Wardlaw, J., Jun 2016, In: Neurobiology of Aging. 42, p. 116-123

    Research output: Contribution to journalArticlepeer-review

  26. Reproducibility and variability of quantitative MRI markers in cerebral small vessel disease

    De Guio, F., Jouvent, E., Biessels, G. J., Black, SE., Brayne, C., Chen, C., Cordonnier, C., de Leeuw, F-E., Dichgans, M., Doubal, F., Duering, M., Dufouil, C., Duzel, E., Fazekas, F., Hachinski, V., Ikram, M. A., Linn, J., Matthews, P. M., Mazoyer, B., Mok, V. & 21 others, Norrving, B., O'Brien, J. T., Pantoni, L., Ropele, S., Sachdev, P. S., Schmidt, R., Seshadri, S., Smith, E. E., Sposato, LA., Stephan, B., Swartz, R., Tzourio, C., van Buchem, M., van der Lugt, A., van Oostenbrugge, R., Vernooij, M. W., Viswanathan, A., Werring, D., Wollenweber, F., Wardlaw, J. & Chabriat, H., 11 May 2016, In: Journal of Cerebral Blood Flow and Metabolism.

    Research output: Contribution to journalArticlepeer-review

  27. IST-3 stroke trial data available

    Sandercock, P., Wardlaw, J., Lindley, R., Whiteley, W. & Cohen, G., 7 May 2016, In: The Lancet. 387, 10031

    Research output: Contribution to journalLetterpeer-review

  28. Modulation of retinal image vasculature analysis to extend utility and provide secondary value from optical coherence tomography imaging

    Cameron, J., Ballerini, L., Langan, C., Warren, C., Denholm, N., Smart, K. & MacGillivray, T., 2 May 2016, In: Journal of Medical Imaging. 3, 2

    Research output: Contribution to journalLetterpeer-review

  29. Continuing versus Stopping Prestroke Antihypertensive Therapy in Acute Intracerebral Hemorrhage: A Subgroup Analysis of the Efficacy of Nitric Oxide in Stroke Trial

    Krishnan, K., Scutt, P., Woodhouse, L., Adami, A., Becker, J. L., Cala, L. A., Casado, A. M., Chen, C., Dineen, R. A., Gommans, J., Koumellis, P., Christensen, H., Collins, R., Czlonkowska, A., Lees, K. R., Ntaios, G., Ozturk, S., Phillips, S. J., Sprigg, N., Szatmari, S. & 2 others, Wardlaw, J. M. & Bath, P. M., 1 May 2016, In: Journal of Stroke and Cerebrovascular Diseases. 25, 5, p. 1017-1026 10 p.

    Research output: Contribution to journalArticlepeer-review

  30. Imaging signatures of meningioma and low-grade glioma: a diffusion tensor, magnetization transfer and quantitative longitudinal relaxation time MRI study

    Piper, R. J., Mikhael, S., Wardlaw, J., Laidlaw, D. H., Whittle, I. & Bastin, M., May 2016, In: Magnetic Resonance Imaging. 34, p. 596-602

    Research output: Contribution to journalArticlepeer-review

  31. Magnetic Resonance Imaging for Assessment of Cerebrovascular Reactivity in Cerebral Small Vessel Disease. A Systematic Review.

    Blair, G., Doubal, F., Thrippleton, M., Marshall, I. & Wardlaw, J., May 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, p. 833-41

    Research output: Contribution to journalArticlepeer-review

  32. Observer reliability of CT Perfusion scans

    El Tawil, S., Mair, G., Huang, X., Sakka, E., Palmer, J., Ford, I., Kalra, L., Muir, K. & Wardlaw, J., May 2016, p. 447-448. 2 p.

    Research output: Contribution to conferencePosterpeer-review

  33. Visual Scoring Versus Computational Volume Measures of Perfusion Defects In Acute Ischaemic Stroke

    Mair, G., Carpenter, T., Cohen, G., Lindley, R., Sandercock, P. & Wardlaw, J., May 2016, p. 458. 1 p.

    Research output: Contribution to conferencePosterpeer-review

  34. Cytomegalovirus infection is associated with an increase in systolic blood pressure in older individuals

    Firth, C., Wardlaw, J., Ritchie, S. J., Ferro, C. J., Deary, I., Starr, J. & Moss, P., 12 Apr 2016, In: QJM: An International Journal of Medicine. 109, 9, p. 595-600 hcw026.

    Research output: Contribution to journalArticlepeer-review

  35. Cerebrovascular disease in rheumatic diseases. A systematic review and meta-analysis

    Wiseman, S., Ralston, S. & Wardlaw, J., Apr 2016, In: Stroke. 47, p. 943-950

    Research output: Contribution to journalArticlepeer-review

  36. Trait Conscientiousness and the Personality Meta-Trait Stability are Associated with Regional White Matter Microstructure

    Lewis, G. J., Cox, S., Booth, T., Muñoz Maniega, S., Royle, N., Valdes Hernandez, M., Wardlaw, J., Bastin, M. & Deary, I., 24 Mar 2016, In: Social Cognitive and Affective Neuroscience.

    Research output: Contribution to journalArticlepeer-review

  37. Association of neuropathic limb pain in multiple sclerosis with cognition , behaviour, and measures of brain structure: a case-control MRI neuroimaging study

    Foley, P., Pernet, C., Valdes Hernandez, M., Roberts, N., Kong, Y., Sellar, R., Colvin, L., Weir, C., Bak, T., Chandran, S., Tracey, I. & Fallon, M., 25 Feb 2016, In: The Lancet. 387, S45, p. 45 1 p.

    Research output: Contribution to journalMeeting abstractpeer-review

  38. Author Response: ABCD2 score and secondary stroke prevention: Meta-analysis and effect per 1,000 patients triaged

    Wardlaw, J. M., Brazzelli, M., Chappell, F., Dennis, M. S. & Sandercock, P. A. G., 16 Feb 2016, In: Neurology. 86, 7, p. 697 1 p.

    Research output: Contribution to journalLetterpeer-review

  39. Author Response

    Wardlaw, J. M., Brazzelli, M., Chappell, F., Dennis, M. S. & Sandercock, P. A. G., 16 Feb 2016, In: Neurology. 86, 7, p. 697 1 p.

    Research output: Contribution to journalLetterpeer-review

  40. Polygenic risk of ischemic stroke is associated with cognitive ability

    Harris, S. E., Malik, R., Marioni, R., Campbell, A., Seshadri, S., Worrall, B. B., Sudlow, C. L. M., Hayward, C., Bastin, M. E., Starr, J. M., Porteous, D. J., Wardlaw, J. M., Deary, I. J. & METASTROKE Consortium, 16 Feb 2016, In: Neurology. 86, 7, p. 611-618 8 p.

    Research output: Contribution to journalArticlepeer-review

  41. A structural and functional magnetic resonance imaging dataset of brain tumour patients.

    Pernet, C., Krzysztof, G., Job, D., Rodriguez Gonzalez, D., Whittle, I. & Wardlaw, J., 2 Feb 2016, In: Scientific Data. 6 p., 160003.

    Research output: Contribution to journalArticlepeer-review

  42. Cerebral small vessel disease: capillary pathways to stroke and cognitive decline

    Ostergaard, L., Sondergaard, T., Moreton, F., Hansen, MB., Wardlaw, J., Dalkara, T., Markus, H. S. & Muir, K., Feb 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, 2, p. 302-325

    Research output: Contribution to journalArticlepeer-review

  43. Evaluation of a pre-surgical functional MRI workflow: From data acquisition to reporting

    Pernet, C., Krzysztof, G., Job, D., Rodriguez Gonzalez, D., Storkey, A., Whittle, I. & Wardlaw, J., Feb 2016, In: International journal of medical informatics. 86, p. 37-42 6 p.

    Research output: Contribution to journalArticlepeer-review

  44. Identification of imaging selection patterns in acute ischemic stroke patients and the influence on treatment and clinical trial enrolment decision making

    Luby, M., Warach, S. J., Albers, G. W., Baron, JC., Cognard, C., Dávalos, A., Donnan, G. A., Fiebach, JB., Fiehler, J., Hacke, W., Lansberg, M. G., Liebeskind, DS., Mattle, H. P., Oppenheim, C., Schellinger, P. D., Wardlaw, J. & Wintermark, M., Feb 2016, In: International Journal of Stroke. 11, p. 180-190

    Research output: Contribution to journalArticlepeer-review

  45. A brain imaging repository of normal structural MRI across the life course: Brain Images of Normal Subjects (BRAINS)

    Job, D., Dickie, D. A., Rodriguez Gonzalez, D., Robson, A., Danso, S., Pernet, C., Bastin, M., Boardman, J. P., Murray, A. D., Ahearn, T. S., Waiter, G. D., Staff, R. T., Deary, I., Shenkin, S. D. & Wardlaw, J., 18 Jan 2016, In: NeuroImage.

    Research output: Contribution to journalArticlepeer-review

  46. Development and initial evaluation of a semi-automatic approach to assess perivascular spaces on conventional magnetic resonance images

    Wang, X., Valdes Hernandez, M., Doubal, F., Chappell, F., Piper, R. J., Deary, I. & Wardlaw, J., 15 Jan 2016, In: Journal of Neuroscience Methods. 257, p. 34-44

    Research output: Contribution to journalArticlepeer-review

  47. Effect of alteplase on the CT hyperdense artery sign and functional outcome after ischemic stroke

    Mair, G., von Kummer, R., Morris, Z., von Heijne, A., Bradey, N., Cala, L., Peeters, A., Farrall, A., Adami, A., Potter, G., Cohen, G., Sandercock, P., Lindley, R., Wardlaw, J. & IST-3 Collaborative Group, 12 Jan 2016, In: Neurology. 86, p. 1-8

    Research output: Contribution to journalArticlepeer-review

  48. Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke

    Traylor, M., Zhang, CR., Adib-samii, P., Devan, WJ., Parsons, OE., Lanfranconi, S., Gregory, S., Cloonan, L., Falcone, GJ., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Barrick, T. R., Moynihan, B., Lewis, CM., Boncoraglio, G., Lemmens, R., Thijs, V., Sudlow, C., Wardlaw, J. & 11 others, Rothwell, P. M., Meschia, J. F., Worrall, B. B., Levi, C., Bevan, S., Furie, K. L., Dichgans, M., Rosand, J., Markus, H. S., Rost, NS. & the International Stroke Genetics Consortium, 12 Jan 2016, In: Neurology. 86, p. 146-153

    Research output: Contribution to journalArticlepeer-review

  49. Blood pressure and sodium: association with MRI markers in cerebral small vessel disease

    Heye, A. K., Thrippleton, M., Chappell, F., Valdes Hernandez, M., Armitage, P., Makin, S., Munoz-Maniega, S., Sakka, E., Flatman, P., Dennis, M. & Wardlaw, J., Jan 2016, In: Journal of Cerebral Blood Flow and Metabolism. 36, p. 264-274

    Research output: Contribution to journalArticlepeer-review

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