Edinburgh Research Explorer

Alastair Kerr

(Former employee or visitor)

  1. 2020
  2. Convergent genes shape budding yeast pericentromeres

    Paldi, F., Alver, B., Robertson, D., Schalbetter, S. A., Kerr, A., Kelly, D., Baxter, J., Neale, M. & Marston, A., 4 Jun 2020, In: Nature. 582, p. 119-123 5 p.

    Research output: Contribution to journalArticlepeer-review

  3. A multistage sequencing strategy pinpoints many novel and candidate disease alleles for orphan Disease Emery-Dreifuss Muscular Dystrophy and Supports Gene Misregulation as its Pathomechanism

    Meinke, P., Kerr, A., Czapiewski, R., de las Heras, J., Wehnert, M., Schirmer, E., Harris, E., Kölbel, H. & Muntoni, F., 1 Jan 2020, In: EBioMedicine. 51, 102587.

    Research output: Contribution to journalArticlepeer-review

  4. 2019
  5. Telomere elongation through hTERT immortalization leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford progeria syndrome fibroblasts, expressing a novel SUN1 isoform

    Bikkul, M. U., Faragher, R. G. A., Worthington, G., Meinke, P., Kerr, A. R. W., Sammy, A., Riyahi, K., Horton, D., Schirmer, E. C., Hubank, M., Kill, I. R., Anderson, R. M., Slijepcevic, P., Makarov, E. & Bridger, J. M., 1 Jun 2019, In: Genes, Chromosomes and Cancer. 58, 6, p. 341-356 16 p.

    Research output: Contribution to journalArticlepeer-review

  6. In vitro BioID: Mapping the CENP-A microenvironment with high temporal and spatial resolution

    Remnant, L., Booth, D. G., Vargiu, G., Spanos, C., Kerr, A. R. W. & Earnshaw, W. C., 20 Mar 2019, In: Molecular Biology of the Cell. 30, 11, p. 1314-1325 12 p.

    Research output: Contribution to journalArticlepeer-review

  7. A rapid computational approach identifies SPICE1 as an Aurora kinase substrate

    Deretic, J., Kerr, A. & Welburn, J. P. I., 31 Jan 2019, In: Molecular Biology of the Cell. 30, 3, p. 312-323 12 p.

    Research output: Contribution to journalArticlepeer-review

  8. 2018
  9. Toxicity of overexpressed MeCP2 is independent of HDAC3 activity

    Koerner, M. V., Fitzpatrick, L., Selfridge, J., Guy, J., De Sousa, D., Tillotson, R., Kerr, A., Sun, Z., Lazar, M. A., Lyst, M. J. & Bird, A., 1 Dec 2018, In: Genes & Development. 32, 23-24, p. 1514-1524 11 p.

    Research output: Contribution to journalArticlepeer-review

  10. PuLSE: Quality control and quantification of peptide sequences explored by phage display libraries

    Shave, S., Mann, S., Koszela, J., Kerr, A. & Auer, M., 23 Feb 2018, In: PLoS ONE. 13, 2, 10 p., e0193332.

    Research output: Contribution to journalArticlepeer-review

  11. 2017
  12. Lin28a uses distinct mechanisms of binding to RNA and affects positively and negatively miRNA levels

    Hobor, F., Nowak, J. S., Velasco, A., Choudhurry, N., Heikel, G., Kerr, A., Ramos, A. & Michlewski, G., 1 Mar 2017, In: RNA.

    Research output: Contribution to journalArticlepeer-review

  13. Tissue-specific NETs alter genome organization and regulation even in a heterologous system

    de las Heras, J. I., Zuleger, N., Batrakou, D. G., Czapiewski, R., Kerr, A. R. W. & Schirmer, E. C., 3 Jan 2017, In: Nucleus (Austin, Tex.). p. 1-17 17 p.

    Research output: Contribution to journalArticlepeer-review

  14. 2016
  15. The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells

    Termanis, A., Torrea, N., Culley, J., Kerr, A., Ramsahoye, B. & Stancheva, I., 19 Sep 2016, In: Nucleic Acids Research.

    Research output: Contribution to journalArticlepeer-review

  16. Loss of Tet1 associated 5-hydroxymethylcytosine is concomitant with aberrant promoter hypermethylation in liver cancer

    Thomson, J. P., Ottaviano, R., Unterberger, E., Lempia inen, H., Muller, A., Terranova, R., Illingworth, R. S., Webb, S., Kerr, A. R., Lyall, M. J., Drake, A. J., Wolf, C. R., Moggs, J. G., Schwarz, M. & Meehan, R. R., 6 Apr 2016, In: Cancer Research.

    Research output: Contribution to journalArticlepeer-review

  17. The molecular basis of variable phenotypic severity among common missense mutations causing Rett syndrome

    Brown, K., Selfridge, J., Lagger, S., Connelly, J., De Sousa, D., Kerr, A., Webb, S., Guy, J., Merusi, C., Koerner, M. V. & Bird, A., 1 Feb 2016, In: Human Molecular Genetics. 25, 3, p. 558-570

    Research output: Contribution to journalArticlepeer-review

  18. 2015
  19. The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Vincenten, N., Kuhl, L. M., Lam, I., Oke, A., Kerr, A. R. W., Hochwagen, A., Fung, J., Keeney, S., Vader, G. & Marston, A. L., 14 Dec 2015, In: eLIFE. 4, 26 p., e10850.

    Research output: Contribution to journalArticlepeer-review

  20. TD-60 links RalA GTPase function to the CPC in mitosis

    Papini, D., Langemeyer, L., Abad, M. A., Kerr, A., Samejima, I., Eyers, P. A., Arulanandam, A., Higgins, J. M. G., Barr, F. A. & Earnshaw, W. C., 9 Jul 2015, In: Nature Communications. 6, 7678.

    Research output: Contribution to journalArticlepeer-review

  21. Structural evidence for Scc4-dependent localization of cohesin loading

    Hinshaw, S. M., Makrantoni, V., Kerr, A., Marston, A. L. & Harrison, S. C., 3 Jun 2015, In: eLIFE. 4, JUNE, 15 p., e06057.

    Research output: Contribution to journalArticlepeer-review

  22. Inter-individual variability contrasts with regional homogeneity in the human brain DNA methylome

    Illingworth, R. S., Gruenewald-Schneider, U., De Sousa, D., Webb, S., Merusi, C., Kerr, A. R. W., James, K. D., Smith, C., Walker, R., Andrews, R. & Bird, A. P., 30 Jan 2015, In: Nucleic Acids Research. 43, 2, p. 732-744 13 p.

    Research output: Contribution to journalArticlepeer-review

  23. 2014
  24. Genome-Wide Distribution of RNA-DNA Hybrids Identifies RNase H Targets in tRNA Genes, Retrotransposons and Mitochondria

    El Hage, A., Webb, S., Kerr, A. & Tollervey, D., 30 Oct 2014, In: PLoS Genetics. 10, 10, e1004716.

    Research output: Contribution to journalArticlepeer-review

  25. Shugoshin biases chromosomes for biorientation through condensin recruitment to the pericentromere

    Verzijlbergen, K. F., Nerusheva, O. O., Kelly, D., Kerr, A., Clift, D., Alves, F. D. L., Rappsilber, J. & Marston, A. L., 4 Feb 2014, In: eLIFE. 2014, 3, e01374.

    Research output: Contribution to journalArticlepeer-review

  26. 2013
  27. Tissue specificity in the nuclear envelope supports its functional complexity

    de Las Heras, J. I., Meinke, P., Batrakou, D. G., Srsen, V., Zuleger, N., Kerr, A. R. & Schirmer, E. C., 2013, In: Nucleus (Austin, Tex.). 4, 6, p. 460-77 18 p.

    Research output: Contribution to journalArticlepeer-review

  28. 2012
  29. Cfp1 integrates both CpG content and gene activity for accurate H3K4me3 deposition in embryonic stem cells

    Clouaire, T., Webb, S., Skene, P., Illingworth, R., Kerr, A., Andrews, R., Lee, J-H., Skalnik, D. & Bird, A., 1 Aug 2012, In: Genes & Development. 26, 15, p. 1714-1728 15 p.

    Research output: Contribution to journalArticlepeer-review

  30. Co-transcriptional degradation of aberrant pre-mRNA by Xrn2

    Davidson, L., Kerr, A. & West, S., 2012, In: EMBO Journal. 31, 11, p. 2566-2578 13 p.

    Research output: Contribution to journalArticlepeer-review

  31. Many mechanisms, one entrance: membrane protein translocation into the nucleus

    Zuleger, N., Kerr, A. R. W. & Schirmer, E. C., 2012, In: Cellular and Molecular Life Sciences.

    Research output: Contribution to journalArticle

  32. 2011
  33. Several Novel Nuclear Envelope Transmembrane Proteins Identified in Skeletal Muscle Have Cytoskeletal Associations

    Wilkie, G. S., Korfali, N., Swanson, S. K., Malik, P., Srsen, V., Batrakou, D. G., de las Heras, J., Zuleger, N., Kerr, A. R. W., Florens, L. & Schirmer, E. C., Jan 2011, In: Molecular and Cellular Proteomics. 10, 1, M110.003129.

    Research output: Contribution to journalArticlepeer-review

  34. Cell type--specific DNA methylation at intragenic CpG islands in the immune system

    Deaton, A. M., Webb, S., Kerr, A. R. W., Illingworth, R. S., Guy, J., Andrews, R. & Bird, A., 2011, In: Genome Research. 21, 7, p. 1074-1086 13 p.

    Research output: Contribution to journalArticlepeer-review

  35. FG repeats facilitate integral protein trafficking to the inner nuclear membrane

    Kerr, A. R. W. & Schirmer, E. C., 2011, In: Communicative and Integrative Biology . 4, 5, p. 557-559 3 p.

    Research output: Contribution to journalArticlepeer-review

  36. System analysis shows distinct mechanisms and common principles of nuclear envelope protein dynamics

    Zuleger, N., Kelly, D. A., Richardson, A. C., Kerr, A. R. W., Goldberg, M. W., Goryachev, A. B. & Schirmer, E. C., 2011, In: Journal of Cell Biology. 193, 1, p. 109-123 15 p.

    Research output: Contribution to journalArticlepeer-review

  37. 2010
  38. CpG islands influence chromatin structure via the CpG-binding protein Cfp1

    Thomson, J. P., Skene, P. J., Selfridge, J., Clouaire, T., Guy, J., Webb, S., Kerr, A. R. W., Deaton, A., Andrews, R., James, K. D. & Bird, A., Apr 2010, In: Nature. 464, 7291, p. 1082-1086 5 p.

    Research output: Contribution to journalArticlepeer-review

  39. Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

    Simmer, F., Buscaino, A., Kos-Braun, I. C., Kagansky, A., Boukaba, A., Urano, T., Kerr, A. R. W. & Allshire, R. C., 2010, In: EMBO Reports. 11, 2, p. 112-118 7 p.

    Research output: Contribution to journalArticlepeer-review

  40. Neuronal MeCP2 is expressed at near histone-octamer levels and globally alters the chromatin state

    Skene, P. J., Illingworth, R. S., Webb, S., Kerr, A. R. W., James, K. D., Turner, D. J., Andrews, R. & Bird, A. P., 2010, In: Molecular Cell. 37, 4, p. 457-468 12 p.

    Research output: Contribution to journalArticlepeer-review

  41. Orphan CpG islands identify numerous conserved promoters in the mammalian genome

    Illingworth, R. S., Gruenewald-Schneider, U., Webb, S., Kerr, A. R. W., James, K. D., Turner, D. J., Smith, C., Harrison, D. J., Andrews, R. & Bird, A. P., 2010, In: PLoS Genetics. 6, 9, e1001134.

    Research output: Contribution to journalArticlepeer-review

  42. The leukocyte nuclear envelope proteome varies with cell activation and contains novel transmembrane proteins that affect genome architecture

    Korfali, N., Wilkie, G. S., Swanson, S. K., Srsen, V., Batrakou, D. G., Fairley, E. A. L., Malik, P., Zuleger, N., Goncharevich, A., de Las Heras, J., Kelly, D. A., Kerr, A. R. W., Florens, L. & Schirmer, E. C., 2010, In: Molecular and Cellular Proteomics. 9, 12, p. 2571-85 15 p.

    Research output: Contribution to journalArticlepeer-review

  43. 2009
  44. Evolution by leaps: gene duplication in bacteria

    Serres, M., Kerr, A., McCormack, T. & Riley, M., Nov 2009, In: Biology direct. 4, 1, 17 p., 46.

    Research output: Contribution to journalArticlepeer-review

  45. Comparative proteomic analyses of the nuclear envelope and pore complex suggests a wide range of heretofore unexpected functions

    Batrakou, D. G., Kerr, A. R. W. & Schirmer, E. C., 2009, In: Journal of proteomics. 72, 1, p. 56-70 15 p.

    Research output: Contribution to journalArticlepeer-review

  46. H3 K36 Methylation Helps Determine the Timing of Cdc45 Association with Replication Origins

    Pryde, F., Jain, D., Kerr, A., Curley, R., Mariotti, F. R. & Vogelauer, M., 2009, In: PLoS ONE. 4, 6, p. 1-13 13 p., e5882.

    Research output: Contribution to journalArticlepeer-review

  47. 2008
  48. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes (Proceedings of the National Academy of Sciences of the United States of America (2008) 105, (2457-2462) DOI: 10.1073/pnas. 0712083105)

    Samejima, K., Ogawa, H., Cooke, C. A., Hudson, D. F., MacIsaac, F., Ribeiro, S. A., Vagnarelli, P., Cardinale, S., Kerr, A., Lai, F., Ruchaud, S., Yue, Z. & Earnshaw, W. C., 8 Apr 2008, In: Proceedings of the National Academy of Sciences of the United States of America. 105, 14, p. 5650 1 p.

    Research output: Contribution to journalComment/debatepeer-review

  49. A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

    Illingworth, R., Kerr, A., De Sousa, D., Jørgensen, H., Ellis, P., Stalker, J., Jackson, D., Clee, C., Plumb, R., Rogers, J. & Bird, A., Jan 2008, In: PLoS Biology. 6, 1, e22.

    Research output: Contribution to journalArticlepeer-review

  50. A promoter-hijack strategy for conditional shutdown of multiply spliced essential cell cycle genes

    Samejima, K., Ogawa, H., Cooke, C. A., Hudson, D., MacIsaac, F., Ribeiro, S. A., Vagnarelli, P., Cardinale, S., Kerr, A., Lai, F. & Earnshaw, B., 2008, In: Proceedings of the National Academy of Sciences. 105, 7, p. 2457-2462 1 p.

    Research output: Contribution to journalArticlepeer-review

  51. Molecular and Genetic Analysis of Condensin Function in Vertebrate Cells

    Hudson, D. F., Ohta, S., Freisinger, T., MacIsaac, F., Sennels, L., Alves, F., Lai, F., Kerr, A., Rappsilber, J. & Earnshaw, W. C., 2008, In: Molecular Biology of the Cell. 19, 7, p. 3070-3079 10 p.

    Research output: Contribution to journalArticlepeer-review

  52. 2007
  53. CpG methylation is targeted to transcription units in an invertebrate genome

    Suzuki, M. M., Kerr, A. R. W., De Sousa, D. & Bird, A., May 2007, In: Genome Research. 17, 5, p. 625-631 7 p.

    Research output: Contribution to journalArticlepeer-review

  54. 1997
  55. Systematic base composition variation around the genome of Mycoplasma genitalium, but not Mycoplasma pneumoniae

    Kerr, ARW., Peden, JF. & Sharp, PM., Sep 1997, In: Molecular Microbiology. 25, 6, p. 1177-1179 3 p.

    Research output: Contribution to journalLetterpeer-review