Edinburgh Research Explorer

Prof Amanda Drake, FRCPE

Personal Chair of Epigenetics and Metabolism, Academic Director, Academic Foundation Programme, Associate Director, Edinburgh Clinical Academic Training Programme

Profile photo
Phone: 0131 242 6748

Willingness to take PhD students: Yes

Education/Academic qualification

Doctor of Philosophy (PhD), University of Edinburgh
Bachelor of Medicine and Bachelor of Surgery, Newcastle University

Professional Qualifications

1997Member of the Royal College of Paediatrics and Child Health, MRCPCH

Administrative Roles

Academic Director, Academic Foundation Programme

Associate Director, Edinburgh Clinical Academic Training Programme

Biography

I am a Reader in the Centre for Cardiovascular Science and an Honorary Consultant in Paediatric Endocrinology at the Royal Hospital for Sick Children in Edinburgh. I qualified in Medicine at the University of Newcastle-upon-Tyne and undertook initial paediatric training in South West England. I relocated to Edinburgh to complete a PhD funded by a British Heart Foundation Junior Clinical Research Fellowship, supervised by Professors Brian Walker and Jonathan Seckl. Following completing training in paediatric endocrinology as a Clinical Lecturer in the Department of Child Life and Health in Edinburgh, I took up an MRC Clinician Scientist Fellowship followed by a Scottish Senior Clinical Fellowship.    

My research in a nutshell

My research group has a focus on understanding the interactions between the environment and the epigenome, particularly DNA methylation. Our work includes studies aimed at increasing our understanding of how the environment in early life leads to an increased risk of metabolic and neurodevelopmental disease in later life. We were amongst the first to show that these effects can be transmitted across generations through non-genomic mechanisms. We are also involved in studies aimed at understanding how preterm birth leads to long-term effects on neurodevelopment. Finally, we are undertaking studies aimed at delineating the effects of obesity and metabolic dysfunction on DNA methylation.  

Current Research Interests

Obesity, non-alcoholic fatty liver disease

DNA methylation and hydroxymethylation

Early life programming and intergenerational consequences

Prematurity - effects on cardiometabolic disease risk and neurodevelopment

Collaborative Activity

Professor Richard Meehan

Professor Richard Sharpe

Professor Rebecca Reynolds

Professor Steve Anderton

Dr James Boardman

Dr Richard Chin

Dr John Thomson

Dr Dave Hay

Professor Jeremy Hall (Cardiff)

Professor Paul Fowler (Aberdeen)

Professor Elisabeth Binder (Max Plank, Munich) 

Profs Katri Raikkonen and Johan Eriksson (Helsinki)

Clinical Expertise and Specialisation

Consultant in Paediatric Endocrinology

Research activities & awards

  1. Programme organising Committee

    Activity: Consultancy typesContribution to the work of national or international committees and working groups

  2. Grant review panel member

    Activity: Consultancy typesContribution to the work of national or international committees and working groups

  3. External examiner BMedSci course

    Activity: Examination typesExternal Examiner or Assessor

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