Edinburgh Research Explorer

Ana de Castro Marques

(Former employee or visitor)

Profile photo

Willingness to take PhD students: Yes

Current Research Interests

My current research focus is on cryopreservation techniques for canine hepatocytes with the objective of creating a bank of cells suitable for further development of this area.

Research Interests

Throughout my clinical career I’ve developed a particular interest in liver disease in dogs and human’s. The lack of therapeutic options for increasingly challenging conditions made me look further into cell based therapies and bioartificial liver devices.

Recent advances have shown that canine hepatocytes can be effectively isolated in 2D culture media. However, primary hepatocytes are difficult to maintain and lose hepatic identity and function over time even with sophisticated tissue culture media.

My current research focus is on cryopreservation techniques for canine hepatocytes with the objective of creating a bank of cells suitable for further development of this area.

My particular interest lies on identification and screening of polymers and matrices that will effectively support and prolong hepatocyte identity and function.

Ultimately my goal is to optimise hepatocyte function in vitro allowing further research on evaluation of drug metabolism, investigation of mechanisms of hepatotoxicity and cell signalling and development of target therapeutic protocols for specific liver diseases.

Administrative Roles

Orthopaedic Surgery, Soft Tissue Surgery

Biography

Ana grew up in Oporto, city of good wine and endless sunshine. She graduated from Oporto University in 2001 and after 2 years in Small Animal Practice and a 1 year surgical internship, she completed a 3 year ECVS residency in small animal surgery at the University of Edinburgh.

She was awarded the Australian certificate in small animal Surgery in 2005, the RCVS certificate in small animal surgery in 2007 and the ECVS diploma in small animal surgery in 2013.

Ana has been a Soft Tissue lecturer at the University of Edinburgh since 2008 and thoroughly enjoys conjugating clinical work with undergraduate and postgraduate teaching. Her main interests are oncologic surgery of advanced reconstruction, minimally invasive surgery, interventional radiology and bioartificial liver implants.  

She owns two rescue greyhounds and loves exploring the Scottish outdoor life in her free time.

ID: 16163697