Edinburgh Research Explorer

Andrew Brown

(Former employee or visitor)

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Current Research Interests

The interaction of the immune and haemostatic systems in different disease states and following therapeutic intervention. 

Research Interests

I am interested in the interaction of the immune and haemostatic systems in different disease states and following therapeutic intervention.  Animals with immune-mediated and infectious diseases develop a pro-inflammatory and pro-thrombotic state.  We have demonstrated this using markers of platelet activation (e.g. P selectin expression using flow cytometry) as well as haemostatic assays (thromboelastography and platelet aggregometry). 

Therapies, including blood transfusions are also known to cause a pro-thrombotic and pre-inflammatory state.  This has profound clinical implications including the development of thromboembolic complications that contribute to the morbidity and mortality of the disease. 

I plan to develop an in vitro model of red blood cell transfusion to determine the effects of transfusion on platelet reactivity in dogs.  This will provide the foundations for future studies to investigate the effect of transfusion on platelet reactivity in anaemic dogs in vivo.  We predict that this in vitro approach will allow clinicians, for the first time, to investigate the ability of drugs to decrease platelet activation. 

In a second aspect of my research, I have investigated the use of real-time PCR and subsequent DNA sequencing to rapidly identify patients with an infectious process.  Bacteraemia following dental extractions has been associated with the development of bacterial endocarditis in people and dogs.  This has significant clinical implications including the use of prophylactic antibiotic use despite an unproven link between dental disease and the development of bacterial endocarditis in dogs.  Using the molecular techniques to screen for bacteria, I am investigating the incidence of bacteraemia in animals with dental disease both before and after tooth extraction, and how this is affected by antimicrobial therapy.  I  now aim to use these molecular approaches to describe microbiomes in both health and disease, and how they are affected by therapeutic intervention and critical illness.

Administrative Roles

Small Animal Emergency & Critical Care

Biography

Andrew graduated from the University of Cambridge in 2002, and following an internship at Cambridge he completed a residency at the University of Pennsylvania in Emergency & Critical Care. He became a Diplomate of the American College of Veterinary Emergency & Critical Care in 2006, and worked as an Assistant Professor of Emergency & Critical Care Medicine at Michigan State University. Following 3 years in private referral practice Andrew joined the University of Edinburgh in 2014 as Senior Lecturer, and now leads the Emergency & Critical Care Medicine service. He is one of only three RCVS recognised specialists in Emergency & Critical Care in the UK.

Andrew has lectured internationally, published widely and contributed to multiple textbooks on all aspects of emergency & critical care. His current research focus is the development of diagnostics to rapidly identify sepsis, and haematology/haemostasis in critical illness.

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